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- W2148109926 abstract "Nab-paclitaxel (Abraxane(®)) is an albumin-bound form of paclitaxel that utilizes the natural properties of albumin to improve paclitaxel delivery to the tumor. It is licensed for use in metastatic breast cancer (MBC) at a dose of 260 mg/m(2) Q3W based on its superior therapeutic index versus conventional paclitaxel 175 mg/m(2) Q3W demonstrated in a Phase III study. In a post-hoc analysis, nab-paclitaxel treatment was associated with rapid and dramatic tumor responses in patients with poor prognostic factors (visceral dominant disease, ≥3 metastatic lesions), suggesting it may be a preferred treatment for these patients. Moreover, significant efficacy has been seen with nab-paclitaxel 100 and 150 mg/m(2) QW 3/4, suggesting it may be possible to tailor use of this agent in the future." @default.
- W2148109926 created "2016-06-24" @default.
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- W2148109926 date "2014-02-28" @default.
- W2148109926 modified "2023-09-24" @default.
- W2148109926 title "Evaluating the role of nab-paclitaxel (Abraxane) in women with aggressive metastatic breast cancer" @default.
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- W2148109926 doi "https://doi.org/10.1586/14737140.2014.883922" @default.
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