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- W2148119979 abstract "The accuracy of the initiator tRNA (tRNA fMet ) selection in the ribosomal P-site is central to the fidelity of protein synthesis. A highly conserved occurrence of three consecutive G–C base pairs in the anticodon stem of tRNA fMet contributes to its preferential selection in the P-site. In a genetic screen, using a plasmid borne copy of an inactive tRNA fMet mutant wherein the three G–C base pairs were changed, we isolated Escherichia coli strains that allow efficient initiation with the tRNA fMet mutant. Here, extensive characterization of two such strains revealed novel mutations in the metZWV promoter severely compromising tRNA fMet levels. Low cellular abundance of the chromosomally encoded tRNA fMet allows efficient initiation with the tRNA fMet mutant and an elongator tRNA Gln , revealing that a high abundance of the cellular tRNA fMet is crucial for the fidelity of initiator tRNA selection on the ribosomal P-site in E. coli . We discuss possible implications of the changes in the cellular tRNA fMet abundance in proteome remodeling." @default.
- W2148119979 created "2016-06-24" @default.
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- W2148119979 date "2010-08-26" @default.
- W2148119979 modified "2023-10-08" @default.
- W2148119979 title "Crucial contribution of the multiple copies of the initiator tRNA genes in the fidelity of tRNA fMet selection on the ribosomal P-site in Escherichia coli" @default.
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- W2148119979 doi "https://doi.org/10.1093/nar/gkq760" @default.
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