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- W2148122447 endingPage "522" @default.
- W2148122447 startingPage "507" @default.
- W2148122447 abstract "The formation of occlusive vascular lesions during the course of atherosclerosis, in-stent restenosis, transplant vasculopathy and vessel graft failure is a chronic inflammatory process characterised by excessive cellular proliferation within the injured artery wall. Therefore, candidate targets for the treatment of vasculoproliferative disease include cell cycle regulatory factors, such as cyclin-dependent kinases (CDKs), cyclins, CDK inhibitory proteins (CKIs), tumour suppressors, growth factors and their receptors, and transcription factors involved in cell cycle control. Although several genetically-modified mouse models have conclusively demonstrated that increased cell proliferation aggravates atheroma development, the potential benefit of cytostatic strategies for the treatment of atherosclerosis in the clinic is doubtful because human atherosclerosis is often diagnosed at advanced stages when neointimal proliferation appears low or absent. In contrast, restenosis and graft atherosclerosis appear amenable for cytostatic strategies because neointimal lesions typically develop over a short period of time after revascularisation (e.g., 2 – 12 months) and are localised at the site of the intervention. Vascular interventions, both endovascular and open surgical, allow minimally invasive, easily monitored gene delivery. In this review, the preclinical studies and clinical trials utilising cytostatic gene therapy for occlusive vascular disease will be discussed." @default.
- W2148122447 created "2016-06-24" @default.
- W2148122447 creator A5004405328 @default.
- W2148122447 creator A5060277029 @default.
- W2148122447 date "2006-03-24" @default.
- W2148122447 modified "2023-10-16" @default.
- W2148122447 title "Cytostatic gene therapy for occlusive vascular disease" @default.
- W2148122447 cites W131216719 @default.
- W2148122447 cites W1485698350 @default.
- W2148122447 cites W1517316308 @default.
- W2148122447 cites W1537854451 @default.
- W2148122447 cites W1561059299 @default.
- W2148122447 cites W1600542667 @default.
- W2148122447 cites W1606722513 @default.
- W2148122447 cites W1736564208 @default.
- W2148122447 cites W1841044682 @default.
- W2148122447 cites W1963626132 @default.
- W2148122447 cites W1965772932 @default.
- W2148122447 cites W1970466000 @default.
- W2148122447 cites W1972164937 @default.
- W2148122447 cites W1973427430 @default.
- W2148122447 cites W1976579307 @default.
- W2148122447 cites W1976755994 @default.
- W2148122447 cites W1977139412 @default.
- W2148122447 cites W1977288162 @default.
- W2148122447 cites W1978347107 @default.
- W2148122447 cites W1984583566 @default.
- W2148122447 cites W1984583623 @default.
- W2148122447 cites W1985184104 @default.
- W2148122447 cites W1986525923 @default.
- W2148122447 cites W1987430295 @default.
- W2148122447 cites W1988460287 @default.
- W2148122447 cites W1988803492 @default.
- W2148122447 cites W1990064683 @default.
- W2148122447 cites W1991295431 @default.
- W2148122447 cites W1992346069 @default.
- W2148122447 cites W1995145529 @default.
- W2148122447 cites W1995928382 @default.
- W2148122447 cites W1996126373 @default.
- W2148122447 cites W2000054156 @default.
- W2148122447 cites W2000789132 @default.
- W2148122447 cites W2001670639 @default.
- W2148122447 cites W2003283956 @default.
- W2148122447 cites W2005431808 @default.
- W2148122447 cites W2005972190 @default.
- W2148122447 cites W2006195578 @default.
- W2148122447 cites W2007201432 @default.
- W2148122447 cites W2007499397 @default.
- W2148122447 cites W2008664888 @default.
- W2148122447 cites W2008667843 @default.
- W2148122447 cites W2009383262 @default.
- W2148122447 cites W2010221283 @default.
- W2148122447 cites W2013012232 @default.
- W2148122447 cites W2013641657 @default.
- W2148122447 cites W2014003307 @default.
- W2148122447 cites W2014764441 @default.
- W2148122447 cites W2016696388 @default.
- W2148122447 cites W2016902297 @default.
- W2148122447 cites W2017763556 @default.
- W2148122447 cites W2018102734 @default.
- W2148122447 cites W2019624274 @default.
- W2148122447 cites W2020877539 @default.
- W2148122447 cites W2021375804 @default.
- W2148122447 cites W2027048733 @default.
- W2148122447 cites W2027732432 @default.
- W2148122447 cites W2028534260 @default.
- W2148122447 cites W2029947778 @default.
- W2148122447 cites W2032663584 @default.
- W2148122447 cites W2033149433 @default.
- W2148122447 cites W2034487226 @default.
- W2148122447 cites W2034939062 @default.
- W2148122447 cites W2035413582 @default.
- W2148122447 cites W2037417182 @default.
- W2148122447 cites W2037728756 @default.
- W2148122447 cites W2038870579 @default.
- W2148122447 cites W2040695669 @default.
- W2148122447 cites W2041227486 @default.
- W2148122447 cites W2041518723 @default.
- W2148122447 cites W2043385366 @default.
- W2148122447 cites W2045554095 @default.
- W2148122447 cites W2052881006 @default.
- W2148122447 cites W2053648381 @default.
- W2148122447 cites W2053757989 @default.
- W2148122447 cites W2058344926 @default.
- W2148122447 cites W2058488557 @default.
- W2148122447 cites W2059920730 @default.
- W2148122447 cites W2061404129 @default.
- W2148122447 cites W2061731694 @default.
- W2148122447 cites W2063362575 @default.
- W2148122447 cites W2064005371 @default.
- W2148122447 cites W2065041063 @default.
- W2148122447 cites W2065156973 @default.
- W2148122447 cites W2067815302 @default.
- W2148122447 cites W2068611486 @default.
- W2148122447 cites W2073386260 @default.
- W2148122447 cites W2075333521 @default.
- W2148122447 cites W2075578776 @default.
- W2148122447 cites W2076019958 @default.