FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2148128212> ?p ?o ?g. }

• W2148128212 endingPage "88" @default.
• W2148128212 startingPage "88" @default.
• W2148128212 abstract "Hypoxia, which is a loss of oxygen in tissues, is a common condition in solid tumors due to the tumor outgrowing existing vasculature. Under hypoxic conditions, hypoxia-inducible factor (HIF)-1α rapidly accumulates and transactivates hundreds of genes, such as matrix metalloproteinases (MMPs). MMPs contribute to invasion and metastasis of tumor cells by degrading the surrounding basement membrane and extracellular matrix barriers, which enables the easy migration and spread of cancer cells. We examined whether hypoxia increases tumor cell invasion, and whether increased invasiveness was due to HIF-1α and MMP-9 expression.Transwell invasion assays were performed to demonstrate whether hypoxia enhance tumor invasion by use of MDA-MB-231 breast cancer cells. An immunofluorescence assay was used to demonstrate expression of HIF-1α and MMP-9 under hypoxic conditions. Luciferase and ChiP assays were performed to demonstrate that MMP-9 promoter activity was regulated by HIF-1α.HIF-1α was stabilized under hypoxic conditions and stimulated MMP-9 expression, which affected the tumor invasiveness of breast cancer cells. HIF-1α transactivated the MMP-9 promoter by forming a transcriptional unit with p300, thus increasing expression of MMP-9 transcripts. Zymography indicated that MMP-9 had more gelatinase activity under hypoxic conditions than normoxic conditions. Furthermore, the small GTPase Ras was also activated in response to hypoxia, which then aids stabilization of HIF-1α, and in turn upregulates MMP-9 expression. We also demonstrate that MMP-9 is upregulated concurrently with HIF-1α in tumor tissues from patients with breast cancer.These results suggest that HIF-1α promotes cell invasion through a MMP-9-dependent mechanism and that future antitumor agents could be used to target HIF-1α and MMP-9." @default.
• W2148128212 created "2016-06-24" @default.
• W2148128212 creator A5002152070 @default.
• W2148128212 creator A5011483687 @default.
• W2148128212 creator A5044057899 @default.
• W2148128212 creator A5061854235 @default.
• W2148128212 date "2011-01-01" @default.
• W2148128212 modified "2023-10-01" @default.
• W2148128212 title "Overexpression of MMP-9 and HIF-1α in Breast Cancer Cells under Hypoxic Conditions" @default.
• W2148128212 cites W1493048246 @default.
• W2148128212 cites W1605046409 @default.
• W2148128212 cites W1664517074 @default.
• W2148128212 cites W1886431664 @default.
• W2148128212 cites W1987333076 @default.
• W2148128212 cites W2011810742 @default.
• W2148128212 cites W2030634993 @default.
• W2148128212 cites W2035444091 @default.
• W2148128212 cites W2035565668 @default.
• W2148128212 cites W2040031153 @default.
• W2148128212 cites W2046272184 @default.
• W2148128212 cites W2047587094 @default.
• W2148128212 cites W2054170338 @default.
• W2148128212 cites W2071045537 @default.
• W2148128212 cites W2072227408 @default.
• W2148128212 cites W2092502812 @default.
• W2148128212 cites W2116255337 @default.
• W2148128212 cites W2120807407 @default.
• W2148128212 cites W2122927637 @default.
• W2148128212 cites W2125096092 @default.
• W2148128212 cites W2142786915 @default.
• W2148128212 cites W2144625075 @default.
• W2148128212 cites W2157000380 @default.
• W2148128212 cites W53973778 @default.
• W2148128212 doi "https://doi.org/10.4048/jbc.2011.14.2.88" @default.
• W2148128212 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3148536" @default.
• W2148128212 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21847402" @default.
• W2148128212 hasPublicationYear "2011" @default.
• W2148128212 type Work @default.
• W2148128212 sameAs 2148128212 @default.
• W2148128212 citedByCount "116" @default.
• W2148128212 countsByYear W21481282122012 @default.
• W2148128212 countsByYear W21481282122013 @default.
• W2148128212 countsByYear W21481282122014 @default.
• W2148128212 countsByYear W21481282122015 @default.
• W2148128212 countsByYear W21481282122016 @default.
• W2148128212 countsByYear W21481282122017 @default.
• W2148128212 countsByYear W21481282122018 @default.
• W2148128212 countsByYear W21481282122019 @default.
• W2148128212 countsByYear W21481282122020 @default.
• W2148128212 countsByYear W21481282122021 @default.
• W2148128212 countsByYear W21481282122022 @default.
• W2148128212 countsByYear W21481282122023 @default.
• W2148128212 crossrefType "journal-article" @default.
• W2148128212 hasAuthorship W2148128212A5002152070 @default.
• W2148128212 hasAuthorship W2148128212A5011483687 @default.
• W2148128212 hasAuthorship W2148128212A5044057899 @default.
• W2148128212 hasAuthorship W2148128212A5061854235 @default.
• W2148128212 hasBestOaLocation W21481282121 @default.
• W2148128212 hasConcept C104317684 @default.
• W2148128212 hasConcept C109523444 @default.
• W2148128212 hasConcept C121608353 @default.
• W2148128212 hasConcept C126322002 @default.
• W2148128212 hasConcept C127561419 @default.
• W2148128212 hasConcept C137738243 @default.
• W2148128212 hasConcept C142724271 @default.
• W2148128212 hasConcept C1491633281 @default.
• W2148128212 hasConcept C178790620 @default.
• W2148128212 hasConcept C185592680 @default.
• W2148128212 hasConcept C189165786 @default.
• W2148128212 hasConcept C2776223131 @default.
• W2148128212 hasConcept C2776232661 @default.
• W2148128212 hasConcept C2779013556 @default.
• W2148128212 hasConcept C2779256057 @default.
• W2148128212 hasConcept C2780394083 @default.
• W2148128212 hasConcept C502942594 @default.
• W2148128212 hasConcept C530470458 @default.
• W2148128212 hasConcept C540031477 @default.
• W2148128212 hasConcept C54355233 @default.
• W2148128212 hasConcept C55493867 @default.
• W2148128212 hasConcept C71924100 @default.
• W2148128212 hasConcept C7836513 @default.
• W2148128212 hasConcept C86803240 @default.
• W2148128212 hasConcept C95444343 @default.
• W2148128212 hasConcept C96232424 @default.
• W2148128212 hasConceptScore W2148128212C104317684 @default.
• W2148128212 hasConceptScore W2148128212C109523444 @default.
• W2148128212 hasConceptScore W2148128212C121608353 @default.
• W2148128212 hasConceptScore W2148128212C126322002 @default.
• W2148128212 hasConceptScore W2148128212C127561419 @default.
• W2148128212 hasConceptScore W2148128212C137738243 @default.
• W2148128212 hasConceptScore W2148128212C142724271 @default.
• W2148128212 hasConceptScore W2148128212C1491633281 @default.
• W2148128212 hasConceptScore W2148128212C178790620 @default.
• W2148128212 hasConceptScore W2148128212C185592680 @default.
• W2148128212 hasConceptScore W2148128212C189165786 @default.
• W2148128212 hasConceptScore W2148128212C2776223131 @default.
• W2148128212 hasConceptScore W2148128212C2776232661 @default.
• W2148128212 hasConceptScore W2148128212C2779013556 @default.

• next