Matches in SemOpenAlex for { <https://semopenalex.org/work/W2148142238> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2148142238 endingPage "63" @default.
- W2148142238 startingPage "58" @default.
- W2148142238 abstract "Abstract: The metabotropic glutamate receptor (mGluR) subtype 1 exists as at least three variants (−1a, −1b, and −1c) generated by alternative splicing at the C-terminal domain. Fluorometric Ca2+ measurements were used to compare the concentration dependency of agonist-induced rises in intracellular free Ca2+ concentration ([Ca2+]i) in human embryonic HEK 293 cells transiently expressing rat mGluR1a, mGluR1b, or mGluR1c. The rank order of agonist potencies was quisqualate ≫ (2S,1′S,2′S)-2-(carboxycyclopropyl)glycine (L-CCG-I) > (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid [(1S,3R)-ACPD] and did not differ among the splice variants. However, agonists were consistently more potent at mGluR1a than at mGluR1c and mGluR1b. In the same system, we characterized the agonist pharmacology of two chimeric rat mGluR3/1 receptors where the first and/or the second intracellular loop(s) and the C-terminal domain were exchanged with the corresponding mGluR1a or mGluR1c sequences and that were previously shown to mediate elevations in [Ca2+]i in response to agonists. The potency of agonists was higher at the chimera having the C-terminus of mGluR1a as compared with those having the mGluR1c C-terminus. Both chimeric mGluR3/1 receptors had the same rank order of agonist potencies: L-CCG-I ≫ (1S,3R)-ACPD ∼ quisqualate. These data support the hypothesis that the C-terminal domain of mGluRs plays a role in determining the potency of agonists for inducing mGluR-mediated functional responses." @default.
- W2148142238 created "2016-06-24" @default.
- W2148142238 creator A5000903316 @default.
- W2148142238 creator A5012055127 @default.
- W2148142238 creator A5019620513 @default.
- W2148142238 creator A5023434675 @default.
- W2148142238 creator A5068275125 @default.
- W2148142238 creator A5087767528 @default.
- W2148142238 date "2002-11-19" @default.
- W2148142238 modified "2023-09-25" @default.
- W2148142238 title "The C-Terminal Domain of the mGluR1 Metabotropic Glutamate Receptor Affects Sensitivity to Agonists" @default.
- W2148142238 doi "https://doi.org/10.1046/j.1471-4159.1996.67010058.x" @default.
- W2148142238 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8667026" @default.
- W2148142238 hasPublicationYear "2002" @default.
- W2148142238 type Work @default.
- W2148142238 sameAs 2148142238 @default.
- W2148142238 citedByCount "62" @default.
- W2148142238 countsByYear W21481422382014 @default.
- W2148142238 countsByYear W21481422382015 @default.
- W2148142238 countsByYear W21481422382017 @default.
- W2148142238 countsByYear W21481422382018 @default.
- W2148142238 crossrefType "journal-article" @default.
- W2148142238 hasAuthorship W2148142238A5000903316 @default.
- W2148142238 hasAuthorship W2148142238A5012055127 @default.
- W2148142238 hasAuthorship W2148142238A5019620513 @default.
- W2148142238 hasAuthorship W2148142238A5023434675 @default.
- W2148142238 hasAuthorship W2148142238A5068275125 @default.
- W2148142238 hasAuthorship W2148142238A5087767528 @default.
- W2148142238 hasConcept C119128870 @default.
- W2148142238 hasConcept C170493617 @default.
- W2148142238 hasConcept C174510640 @default.
- W2148142238 hasConcept C207951395 @default.
- W2148142238 hasConcept C26702167 @default.
- W2148142238 hasConcept C2778938600 @default.
- W2148142238 hasConcept C49051014 @default.
- W2148142238 hasConcept C55493867 @default.
- W2148142238 hasConcept C61174792 @default.
- W2148142238 hasConcept C86803240 @default.
- W2148142238 hasConcept C95444343 @default.
- W2148142238 hasConceptScore W2148142238C119128870 @default.
- W2148142238 hasConceptScore W2148142238C170493617 @default.
- W2148142238 hasConceptScore W2148142238C174510640 @default.
- W2148142238 hasConceptScore W2148142238C207951395 @default.
- W2148142238 hasConceptScore W2148142238C26702167 @default.
- W2148142238 hasConceptScore W2148142238C2778938600 @default.
- W2148142238 hasConceptScore W2148142238C49051014 @default.
- W2148142238 hasConceptScore W2148142238C55493867 @default.
- W2148142238 hasConceptScore W2148142238C61174792 @default.
- W2148142238 hasConceptScore W2148142238C86803240 @default.
- W2148142238 hasConceptScore W2148142238C95444343 @default.
- W2148142238 hasIssue "1" @default.
- W2148142238 hasLocation W21481422381 @default.
- W2148142238 hasLocation W21481422382 @default.
- W2148142238 hasOpenAccess W2148142238 @default.
- W2148142238 hasPrimaryLocation W21481422381 @default.
- W2148142238 hasRelatedWork W1974294719 @default.
- W2148142238 hasRelatedWork W2001165441 @default.
- W2148142238 hasRelatedWork W2009311043 @default.
- W2148142238 hasRelatedWork W2016228146 @default.
- W2148142238 hasRelatedWork W2062464911 @default.
- W2148142238 hasRelatedWork W2079107617 @default.
- W2148142238 hasRelatedWork W2122559235 @default.
- W2148142238 hasRelatedWork W2357777527 @default.
- W2148142238 hasRelatedWork W2388980680 @default.
- W2148142238 hasRelatedWork W2398534618 @default.
- W2148142238 hasVolume "67" @default.
- W2148142238 isParatext "false" @default.
- W2148142238 isRetracted "false" @default.
- W2148142238 magId "2148142238" @default.
- W2148142238 workType "article" @default.