FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2148160345> ?p ?o ?g. }

• W2148160345 endingPage "590" @default.
• W2148160345 startingPage "580" @default.
• W2148160345 abstract "Background. Meningococcal outer membrane vesicle (OMV) vaccines are efficacious in humans but have serosubtype-specific serum bactericidal antibody responses directed at the porin protein PorA and the potential for immune selection of PorA-escape mutants.Methods. We prepared an OMV vaccine from a Neisseria meningitidis strain engineered to overexpress genome-derived neisserial antigen (GNA) 1870, a lipoprotein discovered by genome mining that is being investigated for use in a vaccine.Results. Mice immunized with the modified GNA1870-OMV vaccine developed broader serum bactericidal antibody responses than control mice immunized with a recombinant GNA1870 protein vaccine or an OMV vaccine prepared from wild-type N. meningitidis or a combination of vaccines prepared from wild-type N. meningitidis and recombinant protein. Antiserum from mice immunized with the modified GNA1870-OMV vaccine also elicited greater deposition of human C3 complement on the surface of live N. meningitidis bacteria and greater passive protective activity against meningococcal bacteremia in infant rats. A N. meningitidis mutant with decreased expression of PorA was more susceptible to bactericidal activity of anti-GNA1870 antibodies.Conclusions. The modified GNA1870-OMV vaccine elicits broader protection against meningococcal disease than recombinant GNA1870 protein or conventional OMV vaccines and also has less risk of selection of PorA-escape mutants than a conventional OMV vaccine." @default.
• W2148160345 created "2016-06-24" @default.
• W2148160345 creator A5002340962 @default.
• W2148160345 creator A5006315819 @default.
• W2148160345 creator A5010915497 @default.
• W2148160345 creator A5032067506 @default.
• W2148160345 date "2005-08-15" @default.
• W2148160345 modified "2023-09-27" @default.
• W2148160345 title "Protective Antibody Responses Elicited by a Meningococcal Outer Membrane Vesicle Vaccine with Overexpressed Genome‐Derived Neisserial Antigen 1870" @default.
• W2148160345 cites W1548612417 @default.
• W2148160345 cites W1957140814 @default.
• W2148160345 cites W1975355256 @default.
• W2148160345 cites W2007654956 @default.
• W2148160345 cites W2011048047 @default.
• W2148160345 cites W2023869621 @default.
• W2148160345 cites W2044342990 @default.
• W2148160345 cites W2056448686 @default.
• W2148160345 cites W2058948119 @default.
• W2148160345 cites W2098298054 @default.
• W2148160345 cites W2099484936 @default.
• W2148160345 cites W2102044733 @default.
• W2148160345 cites W2102531352 @default.
• W2148160345 cites W2107353241 @default.
• W2148160345 cites W2116285059 @default.
• W2148160345 cites W2119308622 @default.
• W2148160345 cites W2123686037 @default.
• W2148160345 cites W2124672930 @default.
• W2148160345 cites W2126046617 @default.
• W2148160345 cites W2127194736 @default.
• W2148160345 cites W2127214489 @default.
• W2148160345 cites W2134322626 @default.
• W2148160345 cites W2135545913 @default.
• W2148160345 cites W2139884209 @default.
• W2148160345 cites W2142503351 @default.
• W2148160345 cites W2144370704 @default.
• W2148160345 cites W2146799058 @default.
• W2148160345 cites W2147483877 @default.
• W2148160345 cites W2148849781 @default.
• W2148160345 cites W2148967217 @default.
• W2148160345 cites W2151921752 @default.
• W2148160345 cites W2158636933 @default.
• W2148160345 cites W2161637923 @default.
• W2148160345 cites W2165760173 @default.
• W2148160345 cites W2168225301 @default.
• W2148160345 cites W2171656154 @default.
• W2148160345 cites W2400982282 @default.
• W2148160345 doi "https://doi.org/10.1086/432102" @default.
• W2148160345 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2373260" @default.
• W2148160345 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16028126" @default.
• W2148160345 hasPublicationYear "2005" @default.
• W2148160345 type Work @default.
• W2148160345 sameAs 2148160345 @default.
• W2148160345 citedByCount "54" @default.
• W2148160345 countsByYear W21481603452012 @default.
• W2148160345 countsByYear W21481603452013 @default.
• W2148160345 countsByYear W21481603452014 @default.
• W2148160345 countsByYear W21481603452017 @default.
• W2148160345 countsByYear W21481603452018 @default.
• W2148160345 countsByYear W21481603452019 @default.
• W2148160345 countsByYear W21481603452020 @default.
• W2148160345 countsByYear W21481603452021 @default.
• W2148160345 countsByYear W21481603452023 @default.
• W2148160345 crossrefType "journal-article" @default.
• W2148160345 hasAuthorship W2148160345A5002340962 @default.
• W2148160345 hasAuthorship W2148160345A5006315819 @default.
• W2148160345 hasAuthorship W2148160345A5010915497 @default.
• W2148160345 hasAuthorship W2148160345A5032067506 @default.
• W2148160345 hasBestOaLocation W21481603452 @default.
• W2148160345 hasConcept C104317684 @default.
• W2148160345 hasConcept C146587185 @default.
• W2148160345 hasConcept C147483822 @default.
• W2148160345 hasConcept C159047783 @default.
• W2148160345 hasConcept C159654299 @default.
• W2148160345 hasConcept C203014093 @default.
• W2148160345 hasConcept C2776645655 @default.
• W2148160345 hasConcept C2778458888 @default.
• W2148160345 hasConcept C2780454893 @default.
• W2148160345 hasConcept C2780801004 @default.
• W2148160345 hasConcept C40767141 @default.
• W2148160345 hasConcept C523546767 @default.
• W2148160345 hasConcept C54355233 @default.
• W2148160345 hasConcept C547475151 @default.
• W2148160345 hasConcept C86803240 @default.
• W2148160345 hasConcept C89423630 @default.
• W2148160345 hasConceptScore W2148160345C104317684 @default.
• W2148160345 hasConceptScore W2148160345C146587185 @default.
• W2148160345 hasConceptScore W2148160345C147483822 @default.
• W2148160345 hasConceptScore W2148160345C159047783 @default.
• W2148160345 hasConceptScore W2148160345C159654299 @default.
• W2148160345 hasConceptScore W2148160345C203014093 @default.
• W2148160345 hasConceptScore W2148160345C2776645655 @default.
• W2148160345 hasConceptScore W2148160345C2778458888 @default.
• W2148160345 hasConceptScore W2148160345C2780454893 @default.
• W2148160345 hasConceptScore W2148160345C2780801004 @default.
• W2148160345 hasConceptScore W2148160345C40767141 @default.
• W2148160345 hasConceptScore W2148160345C523546767 @default.
• W2148160345 hasConceptScore W2148160345C54355233 @default.
• W2148160345 hasConceptScore W2148160345C547475151 @default.

• next