FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2148164013> ?p ?o ?g. }

• W2148164013 endingPage "355" @default.
• W2148164013 startingPage "346" @default.
• W2148164013 abstract "Calbindin-D(9k) (CaBP-9k) and -D(28k) (CaBP-28k) are cytosolic proteins with EF-hand motifs that have a high affinity for calcium ions. Many types of calcium channels and intracellular calcium binding proteins, such as sodium/calcium exchangers (NCXs) and transient receptor potential cation channels (TRPVs), have been detected in the placenta. In this study, the expression of calcium channels involved in maternal-fetal calcium transport were investigated in wild-type mice versus CaBP-9k, CaBP-28k, and CaBP-9k/28k double knockout (KO) mouse models. The expression of calcium transport genes in three dissected sections of the placenta (maternal, central, and fetal) was examined on gestational day 19 (GD 19). The expression of CaBP-9k, TRPV6, TRPV5, and NCX1 mRNA was high in fetal compared to maternal placenta, while CaBP-28k was abundant in the maternal placenta. CaBP-9k was enhanced in all sections of placenta in CaBP-28k KO mice, whereas CaBP-28k was reduced in CaBP-9k KO mice. The expression of TRPV6, TRPV5, and NCX1 were induced in both maternal and fetal placentas in CaBP-9k KO mice, but were upregulated in maternal and central placentas of CaBP-28k KO mice. The levels of these proteins showed similar patterns with those of their mRNA. Placental CaBP-9k, TRPV6, TRPV5, and NCX1 proteins were abundantly expressed in the intraplacental yolk sac located in the fetal placenta. CaBP-28k did not colocalize with other calcium transport genes, although it was enriched in the placental trophoblasts of the decidual zone in the maternal placenta. These results indicate that placental TRPV6, TRPV5, and NCX1 compensate for CaBPs in CaBP-9k and/or CaBP-28k KO mice, and may take over the roles of CaBP-9k and CaBP-28k to transfer calcium ions in the placenta. Taken together, these results indicate that TRPV6, NCX1, and CaBP-9k in the fetal placenta and CaBP-28k in the maternal placenta may play key roles in controlling calcium transport across the placenta during pregnancy." @default.
• W2148164013 created "2016-06-24" @default.
• W2148164013 creator A5010106280 @default.
• W2148164013 creator A5024635161 @default.
• W2148164013 creator A5049986288 @default.
• W2148164013 creator A5070989428 @default.
• W2148164013 creator A5086987446 @default.
• W2148164013 creator A5089923686 @default.
• W2148164013 date "2012-03-29" @default.
• W2148164013 modified "2023-10-16" @default.
• W2148164013 title "Calcium transport genes are differently regulated in maternal and fetal placenta in the knockout mice of calbindin-D_9kand -D_28k" @default.
• W2148164013 cites W1507203601 @default.
• W2148164013 cites W1517298346 @default.
• W2148164013 cites W1559767698 @default.
• W2148164013 cites W1942834926 @default.
• W2148164013 cites W1966492717 @default.
• W2148164013 cites W1967936683 @default.
• W2148164013 cites W1977111670 @default.
• W2148164013 cites W1980125832 @default.
• W2148164013 cites W1980345371 @default.
• W2148164013 cites W1980646879 @default.
• W2148164013 cites W1980753272 @default.
• W2148164013 cites W1982929403 @default.
• W2148164013 cites W1993794913 @default.
• W2148164013 cites W1998351223 @default.
• W2148164013 cites W1999610370 @default.
• W2148164013 cites W2013637837 @default.
• W2148164013 cites W2018220808 @default.
• W2148164013 cites W2018246600 @default.
• W2148164013 cites W2029670773 @default.
• W2148164013 cites W2033191125 @default.
• W2148164013 cites W2034172337 @default.
• W2148164013 cites W2040113320 @default.
• W2148164013 cites W2041470936 @default.
• W2148164013 cites W2046425824 @default.
• W2148164013 cites W2048168955 @default.
• W2148164013 cites W2049115752 @default.
• W2148164013 cites W2049606832 @default.
• W2148164013 cites W2057402599 @default.
• W2148164013 cites W2059201211 @default.
• W2148164013 cites W2064720767 @default.
• W2148164013 cites W2068520469 @default.
• W2148164013 cites W2068615953 @default.
• W2148164013 cites W2090717793 @default.
• W2148164013 cites W2092467042 @default.
• W2148164013 cites W2102648115 @default.
• W2148164013 cites W2105541452 @default.
• W2148164013 cites W2108079480 @default.
• W2148164013 cites W2115145620 @default.
• W2148164013 cites W2116231344 @default.
• W2148164013 cites W2116434858 @default.
• W2148164013 cites W2116754916 @default.
• W2148164013 cites W2123764654 @default.
• W2148164013 cites W2127152209 @default.
• W2148164013 cites W2133100054 @default.
• W2148164013 cites W2135705556 @default.
• W2148164013 cites W2158473216 @default.
• W2148164013 cites W2161889108 @default.
• W2148164013 cites W2321857788 @default.
• W2148164013 cites W2342502794 @default.
• W2148164013 cites W4247965102 @default.
• W2148164013 cites W52293162 @default.
• W2148164013 doi "https://doi.org/10.1002/mrd.22033" @default.
• W2148164013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22407925" @default.
• W2148164013 hasPublicationYear "2012" @default.
• W2148164013 type Work @default.
• W2148164013 sameAs 2148164013 @default.
• W2148164013 citedByCount "28" @default.
• W2148164013 countsByYear W21481640132012 @default.
• W2148164013 countsByYear W21481640132013 @default.
• W2148164013 countsByYear W21481640132014 @default.
• W2148164013 countsByYear W21481640132015 @default.
• W2148164013 countsByYear W21481640132017 @default.
• W2148164013 countsByYear W21481640132018 @default.
• W2148164013 countsByYear W21481640132019 @default.
• W2148164013 countsByYear W21481640132021 @default.
• W2148164013 countsByYear W21481640132022 @default.
• W2148164013 crossrefType "journal-article" @default.
• W2148164013 hasAuthorship W2148164013A5010106280 @default.
• W2148164013 hasAuthorship W2148164013A5024635161 @default.
• W2148164013 hasAuthorship W2148164013A5049986288 @default.
• W2148164013 hasAuthorship W2148164013A5070989428 @default.
• W2148164013 hasAuthorship W2148164013A5086987446 @default.
• W2148164013 hasAuthorship W2148164013A5089923686 @default.
• W2148164013 hasConcept C122229402 @default.
• W2148164013 hasConcept C126322002 @default.
• W2148164013 hasConcept C134018914 @default.
• W2148164013 hasConcept C153911025 @default.
• W2148164013 hasConcept C155520015 @default.
• W2148164013 hasConcept C170493617 @default.
• W2148164013 hasConcept C172680121 @default.
• W2148164013 hasConcept C182704531 @default.
• W2148164013 hasConcept C26265296 @default.
• W2148164013 hasConcept C2776953305 @default.
• W2148164013 hasConcept C2779234561 @default.
• W2148164013 hasConcept C519063684 @default.
• W2148164013 hasConcept C54355233 @default.
• W2148164013 hasConcept C55493867 @default.

• next