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- W2148173743 abstract "Forty years ago, high mobility group box 1 (HMGB1) was discovered in calf thymus and named according to its electrophoretic mobility in polyacrylamide gels. Now, we know that HMGB1 performs dual functions. Inside the cell, HMGB1 is a highly conserved chromosomal protein acting as a DNA chaperone. Outside of the cell, HMGB1 is a prototypical damage-associated molecular pattern, acting with cytokines, chemokines, and growth factors. During tumor development and in cancer therapy, HMGB1 has been reported to play paradoxical roles in promoting both cell survival and death by regulating multiple signaling pathways, including inflammation, immunity, genome stability, proliferation, metastasis, metabolism, apoptosis, and autophagy. Here, we review the current knowledge of both HMGB1's oncogenic and tumor-suppressive roles and the potential strategies that target HMGB1 for the prevention and treatment of cancer." @default.
- W2148173743 created "2016-06-24" @default.
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- W2148173743 creator A5073859061 @default.
- W2148173743 creator A5087559484 @default.
- W2148173743 creator A5091664811 @default.
- W2148173743 date "2013-07-31" @default.
- W2148173743 modified "2023-10-16" @default.
- W2148173743 title "HMGB1 in Cancer: Good, Bad, or Both?" @default.
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- W2148173743 cites W1935774199 @default.
- W2148173743 cites W1964317462 @default.
- W2148173743 cites W1969305254 @default.
- W2148173743 cites W1972443740 @default.
- W2148173743 cites W1973404097 @default.
- W2148173743 cites W1981562049 @default.
- W2148173743 cites W1982096171 @default.
- W2148173743 cites W1985538633 @default.
- W2148173743 cites W1989162095 @default.
- W2148173743 cites W1999998145 @default.
- W2148173743 cites W2001488800 @default.
- W2148173743 cites W2004266769 @default.
- W2148173743 cites W2005640704 @default.
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- W2148173743 cites W2012743071 @default.
- W2148173743 cites W2017280299 @default.
- W2148173743 cites W2018653121 @default.
- W2148173743 cites W2018905044 @default.
- W2148173743 cites W2019773562 @default.
- W2148173743 cites W2025575974 @default.
- W2148173743 cites W2029068688 @default.
- W2148173743 cites W2034674750 @default.
- W2148173743 cites W2040326100 @default.
- W2148173743 cites W2045316920 @default.
- W2148173743 cites W2051340989 @default.
- W2148173743 cites W2052094075 @default.
- W2148173743 cites W2054433356 @default.
- W2148173743 cites W2059718338 @default.
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- W2148173743 cites W2083080666 @default.
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- W2148173743 cites W2086390177 @default.
- W2148173743 cites W2088377071 @default.
- W2148173743 cites W2093424661 @default.
- W2148173743 cites W2097391811 @default.
- W2148173743 cites W2099297070 @default.
- W2148173743 cites W2102943268 @default.
- W2148173743 cites W2105114667 @default.
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- W2148173743 cites W2114445825 @default.
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- W2148173743 cites W2134316956 @default.
- W2148173743 cites W2134871534 @default.
- W2148173743 cites W2135131688 @default.
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- W2148173743 cites W2148198816 @default.
- W2148173743 cites W2148952735 @default.
- W2148173743 cites W2152568820 @default.
- W2148173743 cites W2155756882 @default.
- W2148173743 cites W2158924104 @default.
- W2148173743 cites W2163147674 @default.
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- W2148173743 doi "https://doi.org/10.1158/1078-0432.ccr-13-0495" @default.
- W2148173743 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3732559" @default.
- W2148173743 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23723299" @default.
- W2148173743 hasPublicationYear "2013" @default.
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