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• W2148188107 abstract "1 The purpose of this study was to determine if corpus cavernosum smooth muscle expresses functional postsynaptic α2-adrenoceptors (AR). 2 The α2-adrenoceptor agonist UK 14,304 elicited concentration-dependent contractions in rabbit corpus cavernosum smooth muscle (CCSM). The half-maximal response occurred at 0.32±0.03 μM and the maximum contraction at 10 μM UK 14,304. 3 Pretreatment of CCSM strips with selective α2-adrenoceptor antagonists, rauwolscine and RS-15385, produced rightward shifts in the dose-response curves to UK 14,304 (pA2 values 7.1 and 8.5, respectively). In contrast, these antagonists did not alter contraction induced by the α1-adrenoceptor agonist phenylephrine (PE) or oxymetazoline. UK 14,304-induced contractions were also inhibited by prazosin (pA2=9.08). 4 UK 14,304-induced contractions, unlike those to PE, were highly dependent on the presence of extracellular Ca2+. 5 [3H]-rauwolscine bound to CCSM membranes with high affinity (Kd=1.5 nM). [3H]-rauwolscine binding was displaced by unlabelled rauwolscine, RS-15385, UK 14,304 and prazosin, but not by PE. 6 UK 14,304 inhibited forskolin and prostaglandin E1 (PGE1)-induced increases in intracellular cyclic AMP concentration in primary cultures of rabbit CCSM cells. 7 These results demonstrate that CCSM expresses Gi-coupled postsynaptic α2-adrenoceptors, and activation of these receptors causes contraction of trabecular smooth muscle. British Journal of Pharmacology (1998) 123, 1237–1245; doi:10.1038/sj.bjp.0701739" @default.
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• W2148188107 date "1998-03-01" @default.
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• W2148188107 title "The expression of functional postsynaptic α₂ -adrenoceptors in the corpus cavernosum smooth muscle" @default.
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• W2148188107 doi "https://doi.org/10.1038/sj.bjp.0701739" @default.
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