FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2148188481> ?p ?o ?g. }

• W2148188481 endingPage "2219" @default.
• W2148188481 startingPage "2216" @default.
• W2148188481 abstract "No AccessJournal of UrologyINVESTIGATIVE UROLOGY1 Nov 2002Increased Expression of Activation Markers in Renal Cell Carcinoma Infiltrating Lymphocytes M. SHABTAI, H. YE, Z. FRISCHER, J. MARTIN, W.C. WALTZER, and K. MALINOWSKI M. SHABTAIM. SHABTAI More articles by this author , H. YEH. YE More articles by this author , Z. FRISCHERZ. FRISCHER More articles by this author , J. MARTINJ. MARTIN More articles by this author , W.C. WALTZERW.C. WALTZER More articles by this author , and K. MALINOWSKIK. MALINOWSKI More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)64358-3AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: As manifested by the presence of immune competent cells, failure to control the progression of renal cell carcinoma by a local immune response attests to impaired local cell mediated immunity. To test this hypothesis we compared the expression of T-cell activation markers in renal cell carcinoma infiltrating lymphocytes with the expression of activation markers of peripheral blood lymphocytes in the same patients. Materials and Methods: Tumor infiltrating lymphocytes were harvested from a patient with renal cell carcinoma undergoing radical nephrectomy. Peripheral blood was obtained before surgery. Tumor infiltrating and peripheral blood lymphocytes were incubated with monoclonal antibodies defining specific differentiation and activation markers on the cell surface, and analyzed by flow cytometry. Cell subsets are expressed as a fraction of the total number of mononuclear cells. Results: The T-cell subset level was significantly higher in peripheral blood than in renal cell carcinoma tissue of the same patient. However, the level of activated T-cell subset expressing HLA-DR was significantly higher in renal cell carcinoma tissue than in peripheral blood. The levels of interleukin-2 receptor and transferrin receptors expressing T-cell subsets were also significantly higher in carcinoma tissue than in peripheral blood. Natural killer cells were found in significantly higher proportions in renal cell carcinoma than in peripheral blood. Conclusions: These results point to significant activation of T, B and natural killer tumor infiltrating lymphocytes. The inability of tumor infiltrating lymphocytes to mount an effective immune response to renal cell carcinoma may be secondary to the presence of suppressive factors in the tumor that prevent tumor infiltrating lymphocytes from transforming into effector cells. These factors may be particularly valuable for the further study of renal cell carcinoma-host interactivity. References 1 : Tumor-specific lysis of human renal cell carcinomas by tumor-infiltrating lymphocytes. I. HLA-A2-restricted recognition of autologous and allogeneic tumor lines. J Immunol1993; 151: 4209. Google Scholar 2 : Interleukin-2 expanded lymphocytes from lymph node and tumor biopsies of human renal cell carcinoma, breast and ovarian cancer. Eur Cytokine Netw2000; 11: 217. Google Scholar 3 : Phenotype, cytokine production and cytolytic capacity of fresh (uncultured) tumor-infiltrating T lymphocytes in human renal cell carcinoma. Clin Exp Immunol1997; 109: 501. Google Scholar 4 : Are renal cell carcinoma cells able to modulate the cytotoxic effect of tumor infiltrating lymphocytes by secretion of interleukin-6?. Anticancer Res1999; 19: 1533. Google Scholar 5 : Mechanisms of interleukin-10-mediated immune suppression. Immunology2001; 103: 131. Google Scholar 6 : Gangliosides GD1a and GM3 induce interleukin-10 production by human T cells. Biochem Biophys Res Commun1999; 256: 41. Google Scholar 7 : Brain-derived gangliosides regulate the cytokine production and proliferation of activated T cells. J Immunol1996; 157: 4333. Google Scholar 8 : Mechanisms of apoptosis in T cells from patients with renal cell carcinoma. Clin Cancer Res1999; 5: 1219. Google Scholar 9 : HLA class I antigens expression in renal cell carcinoma: histopathological and clinical correlation. J Exp Clin Cancer Res1999; 18: 505. Google Scholar 10 : Immunohistochemical analysis of HLA class II antigens and tumor infiltrating mononuclear cells in renal cell carcinoma: correlation with clinical and histopathological data. Neoplasma1999; 46: 173. Google Scholar 11 : Functional dissociation between local and systemic immune response during anti-melanoma peptide vaccination. J Immunol1998; 161: 4183. Google Scholar 12 : [Tumor-immune system interaction in renal cell carcinoma and melanomas. Cytokine transcription in tumors at the time of surgical resection.]. Schweiz Med Wochenschr1994; 124: 930. Google Scholar 13 : Lack of IL-2 cytokine expression despite IL-2 messenger RNA transcription in tumor-infiltrating lymphocytes in primary human breast carcinoma: selective expression of early activation markers. J Immunol1996; 156: 3486. Google Scholar 14 : Inhibition of lymphocyte proliferative responses by renal cell carcinoma extract. Transplant Proc1997; 29: 839. Google Scholar 15 : Immunosuppression by YAC-1 lymphoma: role of shed gangliosides. Cell Immunol1996; 173: 22. Google Scholar 16 : Lead stimulates lymphocyte proliferation through enhanced T cell-B cell interaction. J Pharmacol Exp Ther1999; 288: 714. Google Scholar 17 : The kinetics and temporal expression of T cell activation-associated antigens CD15 (LeuM1), CD30 (Ki-1) EMA and CD11c (LeuM5) by benign activated T cells. Hematol Pathol1992; 6: 193. Google Scholar 18 : Identification of an enriched CD4+ CD8alpha++ CD8beta+ T-cell subset among tumor-infiltrating lymphocytes in human renal cell carcinoma. Int J Cancer1997; 71: 178. Google Scholar 19 : Functional characteristics of cord blood T lymphocytes after lectin and anti-CD3 stimulation. Differences in the way T cells express activation molecules and proliferate. Int J Clin Res1996; 26: 255. Google Scholar 20 : Human IFN-gamma up-regulates IL-2 receptors in mitogen-activated T lymphocytes. Immunology1990; 69: 554. Google Scholar 21 : Differential effects of transferrin receptor blockade on cellular mechanisms involved in graft rejection. Transplant Immunol1999; 7: 131. Google Scholar 22 : Transferrin receptor in T cell activation and transplantation. J Leukocyte Biol1998; 64: 19. Google Scholar 23 : Increased expression of the lymphocyte early activation marker CD69 in peripheral blood correlates with histologic evidence of cardiac allograft rejection. Transplantation2000; 69: 2102. Google Scholar 24 : The role of natural killer cells in immune surveillance of cancer. Curr Opin Immunol1995; 7: 704. Google Scholar 25 : Human renal cell carcinoma cells are able to activate natural killer cells. Int J Cancer1992; 51: 290. Google Scholar 26 : Renal cell carcinoma lines inhibit natural killer activity via the CD94 receptor molecule. Cancer Immunol Immunother2001; 50: 260. Google Scholar 27 : Recombinant interleukin-2 and lymphokine-activated killer cells in renal cancer patients: I. Phenotypic and functional analysis of the peripheral blood mononuclear cells. Cancer Immunol Immunother1990; 32: 161. Google Scholar 28 : Interleukin 7 enhances the proliferation and effector function of tumor-infiltrating lymphocytes from renal-cell carcinoma. Int J Cancer1993; 53: 941. Google Scholar From the Departments of Surgery (Transplantation Service) and Urology, State University of New York at Stony Brook, Stony Brook, New York, and Department of Surgery and Transplantation, Sheba Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel© 2002 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 168Issue 5November 2002Page: 2216-2219 Advertisement Copyright & Permissions© 2002 by American Urological Association, Inc.Keywordsimmune systemcarcinoma, renal cellkidneybloodtumor infiltrating lymphocytesMetricsAuthor Information M. SHABTAI More articles by this author H. YE More articles by this author Z. FRISCHER More articles by this author J. MARTIN More articles by this author W.C. WALTZER More articles by this author K. MALINOWSKI More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
• W2148188481 created "2016-06-24" @default.
• W2148188481 creator A5027206643 @default.
• W2148188481 creator A5031969387 @default.
• W2148188481 creator A5035016916 @default.
• W2148188481 creator A5035545460 @default.
• W2148188481 creator A5042394413 @default.
• W2148188481 creator A5038230004 @default.
• W2148188481 date "2002-11-01" @default.
• W2148188481 modified "2023-10-15" @default.
• W2148188481 title "Increased Expression of Activation Markers in Renal Cell Carcinoma Infiltrating Lymphocytes" @default.
• W2148188481 cites W1481305264 @default.
• W2148188481 cites W1585247532 @default.
• W2148188481 cites W1887940719 @default.
• W2148188481 cites W1965735920 @default.
• W2148188481 cites W1975562276 @default.
• W2148188481 cites W1986544190 @default.
• W2148188481 cites W1995724373 @default.
• W2148188481 cites W1998811483 @default.
• W2148188481 cites W2010594131 @default.
• W2148188481 cites W2025716232 @default.
• W2148188481 cites W2028240889 @default.
• W2148188481 cites W2048023161 @default.
• W2148188481 cites W2060291012 @default.
• W2148188481 cites W2060608469 @default.
• W2148188481 cites W2062489120 @default.
• W2148188481 cites W2106719462 @default.
• W2148188481 cites W2117590388 @default.
• W2148188481 cites W2181546645 @default.
• W2148188481 cites W2332267120 @default.
• W2148188481 doi "https://doi.org/10.1016/s0022-5347(05)64358-3" @default.
• W2148188481 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12394762" @default.
• W2148188481 hasPublicationYear "2002" @default.
• W2148188481 type Work @default.
• W2148188481 sameAs 2148188481 @default.
• W2148188481 citedByCount "16" @default.
• W2148188481 countsByYear W21481884812013 @default.
• W2148188481 countsByYear W21481884812014 @default.
• W2148188481 countsByYear W21481884812015 @default.
• W2148188481 countsByYear W21481884812017 @default.
• W2148188481 countsByYear W21481884812020 @default.
• W2148188481 countsByYear W21481884812023 @default.
• W2148188481 crossrefType "journal-article" @default.
• W2148188481 hasAuthorship W2148188481A5027206643 @default.
• W2148188481 hasAuthorship W2148188481A5031969387 @default.
• W2148188481 hasAuthorship W2148188481A5035016916 @default.
• W2148188481 hasAuthorship W2148188481A5035545460 @default.
• W2148188481 hasAuthorship W2148188481A5038230004 @default.
• W2148188481 hasAuthorship W2148188481A5042394413 @default.
• W2148188481 hasConcept C121608353 @default.
• W2148188481 hasConcept C126322002 @default.
• W2148188481 hasConcept C142724271 @default.
• W2148188481 hasConcept C143998085 @default.
• W2148188481 hasConcept C2777472916 @default.
• W2148188481 hasConcept C2777701055 @default.
• W2148188481 hasConcept C2778326572 @default.
• W2148188481 hasConcept C502942594 @default.
• W2148188481 hasConcept C71924100 @default.
• W2148188481 hasConceptScore W2148188481C121608353 @default.
• W2148188481 hasConceptScore W2148188481C126322002 @default.
• W2148188481 hasConceptScore W2148188481C142724271 @default.
• W2148188481 hasConceptScore W2148188481C143998085 @default.
• W2148188481 hasConceptScore W2148188481C2777472916 @default.
• W2148188481 hasConceptScore W2148188481C2777701055 @default.
• W2148188481 hasConceptScore W2148188481C2778326572 @default.
• W2148188481 hasConceptScore W2148188481C502942594 @default.
• W2148188481 hasConceptScore W2148188481C71924100 @default.
• W2148188481 hasIssue "5" @default.
• W2148188481 hasLocation W21481884811 @default.
• W2148188481 hasLocation W21481884812 @default.
• W2148188481 hasOpenAccess W2148188481 @default.
• W2148188481 hasPrimaryLocation W21481884811 @default.
• W2148188481 hasRelatedWork W2024745271 @default.
• W2148188481 hasRelatedWork W2109246855 @default.
• W2148188481 hasRelatedWork W2168064072 @default.
• W2148188481 hasRelatedWork W2387257437 @default.
• W2148188481 hasRelatedWork W2466417741 @default.
• W2148188481 hasRelatedWork W3025864022 @default.
• W2148188481 hasRelatedWork W3031118135 @default.
• W2148188481 hasRelatedWork W3092640444 @default.
• W2148188481 hasRelatedWork W3101268485 @default.
• W2148188481 hasRelatedWork W4317433436 @default.
• W2148188481 hasVolume "168" @default.
• W2148188481 isParatext "false" @default.
• W2148188481 isRetracted "false" @default.
• W2148188481 magId "2148188481" @default.
• W2148188481 workType "article" @default.