FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2148197907> ?p ?o ?g. }

• W2148197907 endingPage "242" @default.
• W2148197907 startingPage "242" @default.
• W2148197907 abstract "In an earlier study, a cDNA was cloned that showed abundant expression in the eye at postnatal day (P)2 but was downregulated at P10; it was named ODAG (ocular development-associated gene). Its biological function was examined by generating and analyzing transgenic mice overexpressing ODAG (ODAG Tg) in the eye and by identifying ODAG-binding proteins.Transgenic mice were generated by using the mouse Crx promoter. EGFP was designed to be coexpressed with transgenic ODAG, to identify transgene-expressing cells. Overexpression of ODAG was confirmed by Northern and Western blot analysis. IOP was measured with a microneedle technique. The eyes were macroscopically examined and histologically analyzed. EGFP expression was detected by confocal microscope. Proteins associated with ODAG were isolated by pull-down assay in conjugation with mass spectrometry.Macroscopically, ODAG Tg exhibited gradual protrusion of the eyeballs. The mean IOP of ODAG Tg was significantly higher than that of wild-type (WT) littermates. Histologic analysis exhibited optic nerve atrophy and impaired retinal development in the ODAG Tg eye. EGFP was expressed highly in the presumptive outer nuclear layer and weakly in the presumptive inner nuclear layer in the ODAG Tg retina. Rab6-GTPase-activating protein (Rab6-GAP) and its substrate, Rab6, were identified as ODAG-binding proteins.Deregulated expression of ODAG in the eye induces elevated intraocular pressure and optic nerve atrophy and impairs retinal development, possibly by interfering with the Rab6/Rab6-GAP-mediated signaling pathway. These results provide new insights into the mechanisms regulating ocular development, and ODAG Tg would be a novel animal model for human diseases caused by ocular hypertension." @default.
• W2148197907 created "2016-06-24" @default.
• W2148197907 creator A5001549629 @default.
• W2148197907 creator A5004137842 @default.
• W2148197907 creator A5007316747 @default.
• W2148197907 creator A5013713783 @default.
• W2148197907 creator A5014072466 @default.
• W2148197907 creator A5016826148 @default.
• W2148197907 creator A5023359954 @default.
• W2148197907 creator A5026264338 @default.
• W2148197907 creator A5029080541 @default.
• W2148197907 creator A5033277087 @default.
• W2148197907 creator A5048778771 @default.
• W2148197907 creator A5053803582 @default.
• W2148197907 creator A5067328622 @default.
• W2148197907 creator A5072864115 @default.
• W2148197907 creator A5077178617 @default.
• W2148197907 creator A5077335496 @default.
• W2148197907 creator A5091300315 @default.
• W2148197907 date "2009-01-01" @default.
• W2148197907 modified "2023-10-10" @default.
• W2148197907 title "Elevated Intraocular Pressure, Optic Nerve Atrophy, and Impaired Retinal Development in ODAG Transgenic Mice" @default.
• W2148197907 cites W1574402411 @default.
• W2148197907 cites W1589588578 @default.
• W2148197907 cites W1595083713 @default.
• W2148197907 cites W1601865173 @default.
• W2148197907 cites W1965260691 @default.
• W2148197907 cites W1975661596 @default.
• W2148197907 cites W1983323688 @default.
• W2148197907 cites W2007660746 @default.
• W2148197907 cites W2013633022 @default.
• W2148197907 cites W2023279237 @default.
• W2148197907 cites W2028150557 @default.
• W2148197907 cites W2038877086 @default.
• W2148197907 cites W2041316820 @default.
• W2148197907 cites W2042372458 @default.
• W2148197907 cites W2051204481 @default.
• W2148197907 cites W2059344357 @default.
• W2148197907 cites W2065379013 @default.
• W2148197907 cites W2084186902 @default.
• W2148197907 cites W2092360229 @default.
• W2148197907 cites W2101375158 @default.
• W2148197907 cites W2108222684 @default.
• W2148197907 cites W2112616287 @default.
• W2148197907 cites W2127789417 @default.
• W2148197907 cites W2129618668 @default.
• W2148197907 cites W2135930638 @default.
• W2148197907 cites W2139103260 @default.
• W2148197907 cites W2154886355 @default.
• W2148197907 cites W2157492353 @default.
• W2148197907 cites W2163822888 @default.
• W2148197907 cites W2186674126 @default.
• W2148197907 cites W86000632 @default.
• W2148197907 doi "https://doi.org/10.1167/iovs.08-2206" @default.
• W2148197907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18791169" @default.
• W2148197907 hasPublicationYear "2009" @default.
• W2148197907 type Work @default.
• W2148197907 sameAs 2148197907 @default.
• W2148197907 citedByCount "4" @default.
• W2148197907 countsByYear W21481979072016 @default.
• W2148197907 crossrefType "journal-article" @default.
• W2148197907 hasAuthorship W2148197907A5001549629 @default.
• W2148197907 hasAuthorship W2148197907A5004137842 @default.
• W2148197907 hasAuthorship W2148197907A5007316747 @default.
• W2148197907 hasAuthorship W2148197907A5013713783 @default.
• W2148197907 hasAuthorship W2148197907A5014072466 @default.
• W2148197907 hasAuthorship W2148197907A5016826148 @default.
• W2148197907 hasAuthorship W2148197907A5023359954 @default.
• W2148197907 hasAuthorship W2148197907A5026264338 @default.
• W2148197907 hasAuthorship W2148197907A5029080541 @default.
• W2148197907 hasAuthorship W2148197907A5033277087 @default.
• W2148197907 hasAuthorship W2148197907A5048778771 @default.
• W2148197907 hasAuthorship W2148197907A5053803582 @default.
• W2148197907 hasAuthorship W2148197907A5067328622 @default.
• W2148197907 hasAuthorship W2148197907A5072864115 @default.
• W2148197907 hasAuthorship W2148197907A5077178617 @default.
• W2148197907 hasAuthorship W2148197907A5077335496 @default.
• W2148197907 hasAuthorship W2148197907A5091300315 @default.
• W2148197907 hasConcept C102230213 @default.
• W2148197907 hasConcept C104317684 @default.
• W2148197907 hasConcept C105702510 @default.
• W2148197907 hasConcept C141035611 @default.
• W2148197907 hasConcept C142613039 @default.
• W2148197907 hasConcept C153911025 @default.
• W2148197907 hasConcept C169760540 @default.
• W2148197907 hasConcept C2776415932 @default.
• W2148197907 hasConcept C2777093970 @default.
• W2148197907 hasConcept C2778233873 @default.
• W2148197907 hasConcept C2780827179 @default.
• W2148197907 hasConcept C2780837183 @default.
• W2148197907 hasConcept C2781172350 @default.
• W2148197907 hasConcept C54355233 @default.
• W2148197907 hasConcept C55493867 @default.
• W2148197907 hasConcept C86803240 @default.
• W2148197907 hasConcept C95444343 @default.
• W2148197907 hasConceptScore W2148197907C102230213 @default.
• W2148197907 hasConceptScore W2148197907C104317684 @default.
• W2148197907 hasConceptScore W2148197907C105702510 @default.

• next