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- W2148205655 abstract "Los triglicéridos se consideran un factor independiente de riesgo vascular. La influencia, por separado, de polimorfismos en genes como APOE, APOA5, LPL, LIPC y CETP sobre dichos niveles está descrita, por lo que resulta de interés su análisis conjunto y el estudio de interacciones con factores ambientales. Se han genotipado en 1.825 sujetos (80% varones, edad media 36 años) procedentes del estudio ICARIA, el polimorfismo de APOE, 2 variantes de APOA5 (S19W y -1131 T/C), 5 de LPL (D9N, N291S, PvuII, HindIII y S447X), 1 de LIPC (-250G/A) y 1 de CETP (TaqIβ) mediante PCR-restricción y ensayos TaqMan. El efecto conjunto de las variantes se ha analizado mediante regresión lineal con la variable triglicéridos transformada logarítmicamente y corrigiendo por covariables. Las interacciones se han explorado mediante contrastes múltiples. El alelo ɛ4 de APOE, los polimorfismos de APOA5 S19W y -1131T/C y las variantes de LPL, D9N y N291S mostraron un efecto elevador de triglicéridos significativo e independiente. Los polimorfismos HindIII y S447X de LPL se asociaron significativamente con una reducción de los niveles de TG. Las variantes PvuII (LPL), -250G/A (LIPC) y TaqIβ (CETP) no mostraron asociaciones significativas. Se encontró una tendencia estadística (p=0,048) para la interacción entre obesidad abdominal (perímetro de cintura >102 cm en hombres; >88 cm en mujeres) y el alelo APOE-ɛ4. Nuestro trabajo muestra la influencia del alelo ɛ4 de APOE y de las variantes S19W y -1131T/C de APOA5 y D9N, N291S, HindIII y S447X de LPL sobre los niveles de triglicéridos y sugiere un efecto modulador de la obesidad abdominal sobre el alelo ɛ4. Triglyceride levels are considered to be an independent vascular risk factor. The influence of polymorphisms in genes such as APOE, APOA5, LPL, LIPC and CETP on these levels has been separately described. The aim of the present study was to analyze the combined effects of these polymorphisms and their interaction with environmental factors. We genotyped the APOE polymorphism, two variants of APOA5 (S19W and -1131 T/C), five of LPL (D9N, N291S, PvuII, HindIII and S447X), one of LIPC (-250G/A) and one of CETP (TaqIβ) by polymerase chain reaction-restriction and TaqMan assays in 1825 subjects (80% male, mean age 36 years) from the ICARIA study. The combined effect of the variants was analyzed by linear regression with the log-transformed triglyceride variable and adjustment for covariates. The interactions were explored by multiple comparisons. The ɛ4 allele of APOE, the APOA5 polymorphisms S19W and -1131T/C and the LPL variants D9N and N291S independently and significantly increased triglyceride levels. The HindIII and S447X LPL polymorphisms were significantly associated with lower triglyceride levels. The PvuII (LPL), -250G/A (LIPC) and TaqIβ (CETP) variants showed no significant associations. There was a statistical trend (p = 0.048) for an interaction between abdominal obesity (waist circumference >102 cm in men and >88 cm in women) and the APOE-ɛ4 allele. Our study shows the influence of the APOE-ɛ4 allele, the S19W and -1131T/C polymorphisms of APOA5 and the LPL-D9N, N291S, HindIII and S447X variants on triglyceride levels and suggests that the effect of the ɛ4 allele could by modulated by interaction with abdominal obesity." @default.
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- W2148205655 date "2011-03-01" @default.
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- W2148205655 title "Análisis de la influencia de polimorfismos en APOE, APOA5, LPL, LIPC y CETP sobre los niveles de triglicéridos en población laboral malagueña" @default.
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- W2148205655 doi "https://doi.org/10.1016/j.arteri.2011.02.002" @default.
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