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• W2148248504 abstract "Ethanol experiences, during late gestation as well as during nursing, modify the behavioral dynamics of the dam/pup dyad, and leads to heightened ethanol intake in the offspring. This study focuses on: a) behavioral and metabolic changes in intoxicated dams with previous exposure to ethanol during pregnancy and b) infantile consumption of milk when the dam is either under the effects of ethanol or sober. Pregnant rats received water, 1.0 or 2.0 g/kg ethanol, and were administered with water or ethanol during the postpartum period. Intoxication during nursing disrupted the capability of the dam to retrieve the pups and to adopt a crouching posture. These disruptions were attenuated when dams had exposure to ethanol during pregnancy. Ethanol experiences during gestation did not affect pharmacokinetic processes during nursing, whereas progressive postpartum ethanol experience resulted in metabolic tolerance. Pups suckling from intoxicated dams, with previous ethanol experiences, ingested more milk than did infants suckling from ethanol-intoxicated dams without such experience. Ethanol gestational experience results in subsequent resistance to the drug's disruptions in maternal care. Consequently, better maternal care by an intoxicated dam with ethanol experience during gestation facilitates access of pups to milk which could be contaminated with ethanol." @default.
• W2148248504 created "2016-06-24" @default.
• W2148248504 creator A5024355107 @default.
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• W2148248504 date "2008-11-01" @default.
• W2148248504 modified "2023-10-13" @default.
• W2148248504 title "Ethanol exposure during late gestation and nursing in the rat: Effects upon maternal care, ethanol metabolism and infantile milk intake" @default.
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• W2148248504 doi "https://doi.org/10.1016/j.pbb.2008.06.007" @default.
• W2148248504 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2568972" @default.
• W2148248504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18602418" @default.
• W2148248504 hasPublicationYear "2008" @default.
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