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• W2148259638 abstract "Administration of peptide YY 3‐36 (PYY 3‐36 ) to fasting humans or mice shortly before re‐feeding effectively reduced their food intake, but PYY 3‐36 exhibited a functional half‐life of only ∼3 h. Attachment of poly(ethylene glycol) to proteins and peptides (PEGylation) prolongs their half‐life in vivo, but completely inactivated PYY 3‐36 . We developed a reversibly PEGylated PYY 3‐36 derivative by coupling it to a 40 kDa PEG through a spontaneously cleavable linker. The resulting conjugate (PEG 40 –FMS–PYY 3‐36 ) gradually released unmodified PYY 3‐36 in vivo, exhibiting an eightfold increase in its functional half‐life, to ∼24 h. This long‐acting PYY 3‐36 pro‐drug may serve as an effective means for controlling food intake in humans." @default.
• W2148259638 created "2016-06-24" @default.
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• W2148259638 date "2005-03-31" @default.
• W2148259638 modified "2023-10-17" @default.
• W2148259638 title "Reversible PEGylation of peptide YY_3-36prolongs its inhibition of food intake in mice" @default.
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• W2148259638 doi "https://doi.org/10.1016/j.febslet.2005.03.044" @default.
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