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- W2148300265 abstract "Progress and perspectives on the role of RPE cell inflammatory responses in the development of age-related macular degeneration Suofu Qin, Gerard A RodriguesRetinal Disease Research, Department of Biological Sciences, Allergan, Inc., Irvine, CA, USAAbstract: Age-related macular degeneration (AMD) is the leading cause of blindness in developed countries. The etiology of AMD remains poorly understood and no treatment is currently available for the atrophic form of AMD. Atrophic AMD has been proposed to involve abnormalities of the retinal pigment epithelium (RPE), which lies beneath the photoreceptor cells and normally provides critical metabolic support to these light-sensing cells. Cumulative oxidative stress and local inflammation are thought to represent pathological processes involved in the etiology of atrophic AMD. Studies of tissue culture and animal models reveal that oxidative stress-induced injury to the RPE results in a chronic inflammatory response, drusen formation, and RPE atrophy. RPE degeneration in turn causes a progressive degeneration of photoreceptors, leading to the irreversible loss of vision. This review describes some of the potential major molecular and cellular events contributing to RPE death and inflammatory responses. In addition, potential target areas for therapeutic intervention will be discussed and new experimental therapeutic strategies for atrophic AMD will be presented.Keywords: age-related macular degeneration, danger signals, complement, inflammation, retinal pigment epithelial cells" @default.
- W2148300265 created "2016-06-24" @default.
- W2148300265 creator A5076973398 @default.
- W2148300265 creator A5086035626 @default.
- W2148300265 date "2008-12-01" @default.
- W2148300265 modified "2023-10-10" @default.
- W2148300265 title "Progress and perspectives on the role of RPE cell inflammatory responses in the development of age-related macular degeneration" @default.
- W2148300265 cites W109974915 @default.
- W2148300265 cites W12248033 @default.
- W2148300265 cites W1484542705 @default.
- W2148300265 cites W1487528435 @default.
- W2148300265 cites W1488196937 @default.
- W2148300265 cites W1513413810 @default.
- W2148300265 cites W1515599953 @default.
- W2148300265 cites W1516463168 @default.
- W2148300265 cites W1517172525 @default.
- W2148300265 cites W1518351006 @default.
- W2148300265 cites W1519891742 @default.
- W2148300265 cites W1521877864 @default.
- W2148300265 cites W1529146532 @default.
- W2148300265 cites W153415417 @default.
- W2148300265 cites W1576044890 @default.
- W2148300265 cites W1585939626 @default.
- W2148300265 cites W1597900071 @default.
- W2148300265 cites W168035116 @default.
- W2148300265 cites W1739691545 @default.
- W2148300265 cites W1757192287 @default.
- W2148300265 cites W1809957428 @default.
- W2148300265 cites W1883306593 @default.
- W2148300265 cites W19113225 @default.
- W2148300265 cites W1965404473 @default.
- W2148300265 cites W1968249736 @default.
- W2148300265 cites W1969157499 @default.
- W2148300265 cites W1969854304 @default.
- W2148300265 cites W1970157150 @default.
- W2148300265 cites W1970436087 @default.
- W2148300265 cites W1972040236 @default.
- W2148300265 cites W1972854067 @default.
- W2148300265 cites W1974007609 @default.
- W2148300265 cites W1974084948 @default.
- W2148300265 cites W1976231661 @default.
- W2148300265 cites W1977327764 @default.
- W2148300265 cites W1977760393 @default.
- W2148300265 cites W1977790296 @default.
- W2148300265 cites W1978331912 @default.
- W2148300265 cites W1978653478 @default.
- W2148300265 cites W1979517938 @default.
- W2148300265 cites W1980495511 @default.
- W2148300265 cites W1983091454 @default.
- W2148300265 cites W1984186519 @default.
- W2148300265 cites W1984194241 @default.
- W2148300265 cites W1984481064 @default.
- W2148300265 cites W1985156621 @default.
- W2148300265 cites W1985235161 @default.
- W2148300265 cites W1987429671 @default.
- W2148300265 cites W1988517042 @default.
- W2148300265 cites W1989558725 @default.
- W2148300265 cites W1989591478 @default.
- W2148300265 cites W1989822993 @default.
- W2148300265 cites W1990057691 @default.
- W2148300265 cites W1991728641 @default.
- W2148300265 cites W1991794361 @default.
- W2148300265 cites W1993045845 @default.
- W2148300265 cites W1994515616 @default.
- W2148300265 cites W1996110610 @default.
- W2148300265 cites W1996970455 @default.
- W2148300265 cites W1997288094 @default.
- W2148300265 cites W1997761753 @default.
- W2148300265 cites W1998043586 @default.
- W2148300265 cites W1999230530 @default.
- W2148300265 cites W2000383031 @default.
- W2148300265 cites W2000399151 @default.
- W2148300265 cites W2002679216 @default.
- W2148300265 cites W2002993707 @default.
- W2148300265 cites W2004487653 @default.
- W2148300265 cites W2005088734 @default.
- W2148300265 cites W2006582405 @default.
- W2148300265 cites W2006721421 @default.
- W2148300265 cites W2007909676 @default.
- W2148300265 cites W2008189019 @default.
- W2148300265 cites W2009256817 @default.
- W2148300265 cites W2009800174 @default.
- W2148300265 cites W2010703166 @default.
- W2148300265 cites W2010942158 @default.
- W2148300265 cites W2013238661 @default.
- W2148300265 cites W2014881030 @default.
- W2148300265 cites W2015743124 @default.
- W2148300265 cites W2016603048 @default.
- W2148300265 cites W2019805169 @default.
- W2148300265 cites W2020391754 @default.
- W2148300265 cites W2021882325 @default.
- W2148300265 cites W2023677185 @default.
- W2148300265 cites W2026993099 @default.
- W2148300265 cites W2027707278 @default.
- W2148300265 cites W2027716003 @default.
- W2148300265 cites W2030254890 @default.
- W2148300265 cites W2030787754 @default.
- W2148300265 cites W2031062135 @default.