FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2148301997> ?p ?o ?g. }

• W2148301997 endingPage "398" @default.
• W2148301997 startingPage "398" @default.
• W2148301997 abstract "The androgen receptor (AR) is a transcription factor belonging to the family of nuclear receptors that mediate the action of androgen. AR plays an important role in normal development of the prostate, as well as in the progression of prostate cancer. AR is regulated by several posttranslational modifications, including phosphorylation, acetylation, and ubiquitination. In this study, we found that the putative E3 ubiquitin ligase TRIM68, which is preferentially expressed in prostate cancer cells, interacts with AR and enhances transcriptional activity of the AR in the presence of dihydrotestosterone. We also found that TRIM68 functionally interacts with TIP60 and p300, which act as coactivators of AR, and synergizes in the transactivation of AR. Overexpression of TRIM68 in prostate cancer cells caused an increase in secretion of prostate-specific antigen (PSA), one of the most reliable diagnostic markers for prostate cancer, whereas knockdown of TRIM68 attenuated the secretion of PSA and inhibited cell growth and colony-forming ability. Moreover, we showed that TRIM68 expression is significantly up-regulated in human prostate cancers compared with the expression in adjacent normal tissues. These results indicate that TRIM68 functions as a cofactor for AR-mediated transcription and is likely to be a novel diagnostic tool and a potentially therapeutic target for prostate cancer. [Cancer Res 2008;68(9):3486–94]" @default.
• W2148301997 created "2016-06-24" @default.
• W2148301997 creator A5005875682 @default.
• W2148301997 creator A5010806066 @default.
• W2148301997 creator A5023178862 @default.
• W2148301997 creator A5033361641 @default.
• W2148301997 creator A5041310448 @default.
• W2148301997 creator A5068374303 @default.
• W2148301997 creator A5080652822 @default.
• W2148301997 date "2009-04-01" @default.
• W2148301997 modified "2023-09-26" @default.
• W2148301997 title "TRIM68 REGULATES LIGAND-DEPENDENT TRANSCRIPTION OF ANDROGEN RECEPTOR IN PROSTATE CANCER CELLS" @default.
• W2148301997 cites W1576720150 @default.
• W2148301997 cites W1783699960 @default.
• W2148301997 cites W1968455126 @default.
• W2148301997 cites W1977532087 @default.
• W2148301997 cites W1983073183 @default.
• W2148301997 cites W1987338737 @default.
• W2148301997 cites W1990529844 @default.
• W2148301997 cites W1991995900 @default.
• W2148301997 cites W2003696769 @default.
• W2148301997 cites W2003955264 @default.
• W2148301997 cites W2005658600 @default.
• W2148301997 cites W2008044453 @default.
• W2148301997 cites W2022376508 @default.
• W2148301997 cites W2036041445 @default.
• W2148301997 cites W2038208040 @default.
• W2148301997 cites W2039974624 @default.
• W2148301997 cites W2049651307 @default.
• W2148301997 cites W2050826693 @default.
• W2148301997 cites W2064180812 @default.
• W2148301997 cites W2064850779 @default.
• W2148301997 cites W2068592712 @default.
• W2148301997 cites W2071730625 @default.
• W2148301997 cites W2081506603 @default.
• W2148301997 cites W2083995483 @default.
• W2148301997 cites W2087818316 @default.
• W2148301997 cites W2095766576 @default.
• W2148301997 cites W2096285771 @default.
• W2148301997 cites W2096496280 @default.
• W2148301997 cites W2116205673 @default.
• W2148301997 cites W2116773729 @default.
• W2148301997 cites W2131037087 @default.
• W2148301997 cites W2131422252 @default.
• W2148301997 cites W2141466699 @default.
• W2148301997 cites W2146027649 @default.
• W2148301997 cites W2156575042 @default.
• W2148301997 cites W2166987747 @default.
• W2148301997 doi "https://doi.org/10.1016/s0022-5347(09)61130-7" @default.
• W2148301997 hasPublicationYear "2009" @default.
• W2148301997 type Work @default.
• W2148301997 sameAs 2148301997 @default.
• W2148301997 citedByCount "0" @default.
• W2148301997 crossrefType "journal-article" @default.
• W2148301997 hasAuthorship W2148301997A5005875682 @default.
• W2148301997 hasAuthorship W2148301997A5010806066 @default.
• W2148301997 hasAuthorship W2148301997A5023178862 @default.
• W2148301997 hasAuthorship W2148301997A5033361641 @default.
• W2148301997 hasAuthorship W2148301997A5041310448 @default.
• W2148301997 hasAuthorship W2148301997A5068374303 @default.
• W2148301997 hasAuthorship W2148301997A5080652822 @default.
• W2148301997 hasConcept C104317684 @default.
• W2148301997 hasConcept C121608353 @default.
• W2148301997 hasConcept C126322002 @default.
• W2148301997 hasConcept C1292079 @default.
• W2148301997 hasConcept C134018914 @default.
• W2148301997 hasConcept C134459356 @default.
• W2148301997 hasConcept C173396325 @default.
• W2148301997 hasConcept C25602115 @default.
• W2148301997 hasConcept C2776235491 @default.
• W2148301997 hasConcept C2777911890 @default.
• W2148301997 hasConcept C2779881493 @default.
• W2148301997 hasConcept C2780192828 @default.
• W2148301997 hasConcept C502942594 @default.
• W2148301997 hasConcept C54355233 @default.
• W2148301997 hasConcept C61367390 @default.
• W2148301997 hasConcept C71315377 @default.
• W2148301997 hasConcept C71924100 @default.
• W2148301997 hasConcept C81885089 @default.
• W2148301997 hasConcept C86339819 @default.
• W2148301997 hasConcept C86803240 @default.
• W2148301997 hasConceptScore W2148301997C104317684 @default.
• W2148301997 hasConceptScore W2148301997C121608353 @default.
• W2148301997 hasConceptScore W2148301997C126322002 @default.
• W2148301997 hasConceptScore W2148301997C1292079 @default.
• W2148301997 hasConceptScore W2148301997C134018914 @default.
• W2148301997 hasConceptScore W2148301997C134459356 @default.
• W2148301997 hasConceptScore W2148301997C173396325 @default.
• W2148301997 hasConceptScore W2148301997C25602115 @default.
• W2148301997 hasConceptScore W2148301997C2776235491 @default.
• W2148301997 hasConceptScore W2148301997C2777911890 @default.
• W2148301997 hasConceptScore W2148301997C2779881493 @default.
• W2148301997 hasConceptScore W2148301997C2780192828 @default.
• W2148301997 hasConceptScore W2148301997C502942594 @default.
• W2148301997 hasConceptScore W2148301997C54355233 @default.
• W2148301997 hasConceptScore W2148301997C61367390 @default.
• W2148301997 hasConceptScore W2148301997C71315377 @default.
• W2148301997 hasConceptScore W2148301997C71924100 @default.

• next