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- W2148345440 abstract "Essential hypertension is common and is an important risk factor for coronary heart disease, stroke, atherosclerosis, and peripheral vascular disease. Free radicals, nitric oxide (NO), eicosanoids, pro- and anti-inflammatory cytokines, long-chain polyunsaturated fatty acids (LCPUFAs), folic acid, tetrahydrobiopterin (BH4), and vitamin C play a significant role in the pathobiology of hypertension. Vascular endothelium produces vasodilators: prostacyclin (PGI2), NO, and endothelium-derived hyperpolarizing factor, and other vasoactive factors such as endothelins and prostaglandin E1 (PGE1).1 Under physiological conditions a balance is maintained between endothelial vasoconstrictors and vasodilators such that normal blood pressure is maintained. When this balance is altered more in favour of vasoconstrictors and/or when the concentrations of vasodilators are reduced, hypertension develops. One mechanism by which endothelium-dependent vasodilatation is impaired is due to an increase in the oxidative stress that inactivates NO …" @default.
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- W2148345440 date "2008-03-19" @default.
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- W2148345440 title "Risk of type 2 diabetes mellitus in those with hypertension" @default.
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- W2148345440 doi "https://doi.org/10.1093/eurheartj/ehn037" @default.
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