FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2148355940> ?p ?o ?g. }

• W2148355940 endingPage "2958" @default.
• W2148355940 startingPage "2958" @default.
• W2148355940 abstract "To develop an efficient animal colitis-associated carcinogenesis model and to detect the expression of beta-catenin and p53 in this new model.Dysplasia and cancer were investigated in mice pretreated with a single intraperitoneal injection of 20 mg/kg body mass of 1,2-dimethylhydrazine prior to three repetitive oral administrations of 30 g/L dextran sulfate sodium to give conditions similar to the clinically observed active and remission phases. Immunohistochemical staining of beta-catenin and p53 was performed on paraffin-imbedded specimens of animals with cancer and/or dysplasia, those without dysplasia and the normal control animals.At wk 11, four early-invasive adenocarcinomas and 36 dysplasia were found in 10 (90.9%) of the 11 mice that underwent 1,2-dimethylhydrazine-pretreatment with 3 cycles of 30 g/L dextran sulfate sodium-exposure. Dysplasia and/or cancer occurred as flat lesions or as dysplasia-associated lesion or mass (DALM) as observed in humans. Colorectal carcinogenesis occurred primarily on the distal portion of the large intestine. No dysplasia and/or cancer lesion was observed in the control groups with 1,2-dimethylhydrazine pretreatment or 3 cycles of 30 g/L dextran sulfate sodium exposure alone. Immunohistochemical investigation revealed that beta-catenin was translocated from cell membrane to cytoplasm and/or nucleus in 100% of cases with dysplasia and neoplasm, while normal membrane staining was observed in cases without dysplasia and the normal control animals. Nuclear expression of p53 was not detected in specimens.A single dose of procarcinogen followed by induction of chronic ulcerative colitis results in a high incidence of colorectal dysplasia and cancer. Abnormal expression of beta-catenin occurs frequently in dysplasia and cancer. This novel mouse model may provide an excellent vehicle for studying colitis-related colon carcinogenesis." @default.
• W2148355940 created "2016-06-24" @default.
• W2148355940 creator A5012309357 @default.
• W2148355940 creator A5014466654 @default.
• W2148355940 creator A5016647711 @default.
• W2148355940 creator A5016732880 @default.
• W2148355940 date "2004-01-01" @default.
• W2148355940 modified "2023-10-10" @default.
• W2148355940 title "A novel mouse model for colitis-associated colon carcinogenesis induced by 1,2-dimethylhydrazine and dextran sulfate sodium" @default.
• W2148355940 cites W1508746499 @default.
• W2148355940 cites W1540575218 @default.
• W2148355940 cites W1597959509 @default.
• W2148355940 cites W1763504554 @default.
• W2148355940 cites W1855226200 @default.
• W2148355940 cites W1913889129 @default.
• W2148355940 cites W1967137553 @default.
• W2148355940 cites W1975433466 @default.
• W2148355940 cites W1984931384 @default.
• W2148355940 cites W1991168156 @default.
• W2148355940 cites W1993255107 @default.
• W2148355940 cites W2014458461 @default.
• W2148355940 cites W2014581788 @default.
• W2148355940 cites W2025258431 @default.
• W2148355940 cites W2026981137 @default.
• W2148355940 cites W2035869754 @default.
• W2148355940 cites W2041536661 @default.
• W2148355940 cites W2041838266 @default.
• W2148355940 cites W2061616474 @default.
• W2148355940 cites W2062913179 @default.
• W2148355940 cites W2071509829 @default.
• W2148355940 cites W2081785579 @default.
• W2148355940 cites W2088196812 @default.
• W2148355940 cites W2097733438 @default.
• W2148355940 cites W2099467873 @default.
• W2148355940 cites W2106212265 @default.
• W2148355940 cites W2166281548 @default.
• W2148355940 cites W2413992508 @default.
• W2148355940 cites W2427046804 @default.
• W2148355940 cites W2431269651 @default.
• W2148355940 cites W2614197161 @default.
• W2148355940 cites W4235073254 @default.
• W2148355940 cites W4236344160 @default.
• W2148355940 cites W58189747 @default.
• W2148355940 doi "https://doi.org/10.3748/wjg.v10.i20.2958" @default.
• W2148355940 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4576252" @default.
• W2148355940 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15378773" @default.
• W2148355940 hasPublicationYear "2004" @default.
• W2148355940 type Work @default.
• W2148355940 sameAs 2148355940 @default.
• W2148355940 citedByCount "31" @default.
• W2148355940 countsByYear W21483559402012 @default.
• W2148355940 countsByYear W21483559402013 @default.
• W2148355940 countsByYear W21483559402014 @default.
• W2148355940 countsByYear W21483559402015 @default.
• W2148355940 countsByYear W21483559402017 @default.
• W2148355940 countsByYear W21483559402018 @default.
• W2148355940 countsByYear W21483559402019 @default.
• W2148355940 countsByYear W21483559402020 @default.
• W2148355940 countsByYear W21483559402022 @default.
• W2148355940 countsByYear W21483559402023 @default.
• W2148355940 crossrefType "journal-article" @default.
• W2148355940 hasAuthorship W2148355940A5012309357 @default.
• W2148355940 hasAuthorship W2148355940A5014466654 @default.
• W2148355940 hasAuthorship W2148355940A5016647711 @default.
• W2148355940 hasAuthorship W2148355940A5016732880 @default.
• W2148355940 hasBestOaLocation W21483559401 @default.
• W2148355940 hasConcept C121608353 @default.
• W2148355940 hasConcept C126322002 @default.
• W2148355940 hasConcept C142724271 @default.
• W2148355940 hasConcept C185592680 @default.
• W2148355940 hasConcept C204232928 @default.
• W2148355940 hasConcept C2775862500 @default.
• W2148355940 hasConcept C2775894508 @default.
• W2148355940 hasConcept C2777745080 @default.
• W2148355940 hasConcept C2778435480 @default.
• W2148355940 hasConcept C2779134260 @default.
• W2148355940 hasConcept C2779932572 @default.
• W2148355940 hasConcept C2780159080 @default.
• W2148355940 hasConcept C2780479503 @default.
• W2148355940 hasConcept C2781156865 @default.
• W2148355940 hasConcept C526805850 @default.
• W2148355940 hasConcept C555283112 @default.
• W2148355940 hasConcept C71924100 @default.
• W2148355940 hasConcept C90924648 @default.
• W2148355940 hasConceptScore W2148355940C121608353 @default.
• W2148355940 hasConceptScore W2148355940C126322002 @default.
• W2148355940 hasConceptScore W2148355940C142724271 @default.
• W2148355940 hasConceptScore W2148355940C185592680 @default.
• W2148355940 hasConceptScore W2148355940C204232928 @default.
• W2148355940 hasConceptScore W2148355940C2775862500 @default.
• W2148355940 hasConceptScore W2148355940C2775894508 @default.
• W2148355940 hasConceptScore W2148355940C2777745080 @default.
• W2148355940 hasConceptScore W2148355940C2778435480 @default.
• W2148355940 hasConceptScore W2148355940C2779134260 @default.
• W2148355940 hasConceptScore W2148355940C2779932572 @default.
• W2148355940 hasConceptScore W2148355940C2780159080 @default.
• W2148355940 hasConceptScore W2148355940C2780479503 @default.
• W2148355940 hasConceptScore W2148355940C2781156865 @default.

• next