FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2148357788> ?p ?o ?g. }

• W2148357788 endingPage "735" @default.
• W2148357788 startingPage "725" @default.
• W2148357788 abstract "When microinjected into the cytoplasm of 3T3 cells, biotinylated human lamin A rapidly enters the nucleus and gradually becomes incorporated into the nuclear lamina region as determined by immunofluorescence. The incorporation of the microinjected material takes several hours and progresses through a series of morphologically identifiable stages. Within minutes after microinjection, lamin A is found in spots distributed throughout the nucleus, except in nucleolar regions. Over a time course of up to 6 h, these spots appear to decrease in size and number as the biotinylated lamin A becomes associated with the endogenous nuclear lamina. Eventually, the typical nuclear rim staining pattern normally revealed by immunofluorescence with nuclear lamin antibodies is seen with antibiotin. This latter rim staining property is passed on to daughter cells following mitosis. These results indicate that the microinjected biotinylated nuclear lamin A retains those properties required for its integration into the lamina, as well as those necessary for the disassembly and subsequent reassembly of the nuclear lamina during cell division. The initial rapid accumulation into foci and the subsequent slower incorporation into the nuclear lamina appear to be analogous to the stages of incorporation following the microinjection of cytoskeletal intermediate filament proteins such as vimentin and keratin (Vikstrom, K., G. G. Borisy, and R. D. Goldman. 1989. Proc. Natl. Acad. Sci. USA. 86:549-553; Miller, R. K., K. Vikstrom, and R. D. Goldman. 1991. J. Cell Biol. 113:843-855). Foci are also observed in some uninjected cells using nuclear lamin antibodies, indicating that these features are a genuine component of nuclear substructure. Evidence is presented that shows the appearance of these nuclear structures is cell cycle dependent." @default.
• W2148357788 created "2016-06-24" @default.
• W2148357788 creator A5004905921 @default.
• W2148357788 creator A5008848229 @default.
• W2148357788 creator A5051946237 @default.
• W2148357788 creator A5055816508 @default.
• W2148357788 creator A5072506182 @default.
• W2148357788 date "1992-11-15" @default.
• W2148357788 modified "2023-09-26" @default.
• W2148357788 title "Pathway of incorporation of microinjected lamin A into the nuclear envelope." @default.
• W2148357788 cites W11162155 @default.
• W2148357788 cites W1447714944 @default.
• W2148357788 cites W1504297960 @default.
• W2148357788 cites W1515462367 @default.
• W2148357788 cites W1540833582 @default.
• W2148357788 cites W1559380160 @default.
• W2148357788 cites W1569061529 @default.
• W2148357788 cites W1631620978 @default.
• W2148357788 cites W1873199501 @default.
• W2148357788 cites W1912203081 @default.
• W2148357788 cites W1970867680 @default.
• W2148357788 cites W1982915032 @default.
• W2148357788 cites W1997563917 @default.
• W2148357788 cites W2005702190 @default.
• W2148357788 cites W2008900071 @default.
• W2148357788 cites W2015990519 @default.
• W2148357788 cites W2020520526 @default.
• W2148357788 cites W2023114874 @default.
• W2148357788 cites W2025140711 @default.
• W2148357788 cites W2032858454 @default.
• W2148357788 cites W2036410975 @default.
• W2148357788 cites W2040118862 @default.
• W2148357788 cites W2044267903 @default.
• W2148357788 cites W2044729009 @default.
• W2148357788 cites W2052090797 @default.
• W2148357788 cites W2057179447 @default.
• W2148357788 cites W2065634301 @default.
• W2148357788 cites W2072245143 @default.
• W2148357788 cites W2072720547 @default.
• W2148357788 cites W2074226507 @default.
• W2148357788 cites W2074997168 @default.
• W2148357788 cites W2076976386 @default.
• W2148357788 cites W2077375514 @default.
• W2148357788 cites W2080703776 @default.
• W2148357788 cites W2082833702 @default.
• W2148357788 cites W2091955128 @default.
• W2148357788 cites W2095202174 @default.
• W2148357788 cites W2095914770 @default.
• W2148357788 cites W2097325653 @default.
• W2148357788 cites W2099831088 @default.
• W2148357788 cites W2107917368 @default.
• W2148357788 cites W2108298524 @default.
• W2148357788 cites W2114894158 @default.
• W2148357788 cites W2121140096 @default.
• W2148357788 cites W2121491336 @default.
• W2148357788 cites W2130657959 @default.
• W2148357788 cites W2137595520 @default.
• W2148357788 cites W2138040506 @default.
• W2148357788 cites W2140125310 @default.
• W2148357788 cites W2144979281 @default.
• W2148357788 cites W2149467639 @default.
• W2148357788 cites W2153825396 @default.
• W2148357788 cites W2155596329 @default.
• W2148357788 cites W2169413646 @default.
• W2148357788 cites W2338873717 @default.
• W2148357788 cites W2340807121 @default.
• W2148357788 cites W2395900913 @default.
• W2148357788 cites W40997965 @default.
• W2148357788 cites W4234462880 @default.
• W2148357788 doi "https://doi.org/10.1083/jcb.119.4.725" @default.
• W2148357788 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2289687" @default.
• W2148357788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1429833" @default.
• W2148357788 hasPublicationYear "1992" @default.
• W2148357788 type Work @default.
• W2148357788 sameAs 2148357788 @default.
• W2148357788 citedByCount "154" @default.
• W2148357788 countsByYear W21483577882012 @default.
• W2148357788 countsByYear W21483577882013 @default.
• W2148357788 countsByYear W21483577882014 @default.
• W2148357788 countsByYear W21483577882015 @default.
• W2148357788 countsByYear W21483577882017 @default.
• W2148357788 countsByYear W21483577882018 @default.
• W2148357788 countsByYear W21483577882019 @default.
• W2148357788 countsByYear W21483577882020 @default.
• W2148357788 countsByYear W21483577882021 @default.
• W2148357788 crossrefType "journal-article" @default.
• W2148357788 hasAuthorship W2148357788A5004905921 @default.
• W2148357788 hasAuthorship W2148357788A5008848229 @default.
• W2148357788 hasAuthorship W2148357788A5051946237 @default.
• W2148357788 hasAuthorship W2148357788A5055816508 @default.
• W2148357788 hasAuthorship W2148357788A5072506182 @default.
• W2148357788 hasBestOaLocation W21483577881 @default.
• W2148357788 hasConcept C104317684 @default.
• W2148357788 hasConcept C126725582 @default.
• W2148357788 hasConcept C142669718 @default.
• W2148357788 hasConcept C1491633281 @default.
• W2148357788 hasConcept C153911025 @default.
• W2148357788 hasConcept C159654299 @default.

• next