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• W2148358987 abstract "Abstract CD4 T cells are principal producers of IL-21 and are often required for optimal CD8 T cell responses. Therefore, we investigated the importance of IL-21 in determining the phenotypic attributes, functional quality, and maintenance of antiviral CD8 T cells following acute infection with the prototypic mouse pathogen lymphocytic choriomeningitis virus. Previous reports have documented an obligatory role for IL-21 in sustaining CD8 T cell responses during chronic infections. Here we show that the requirements for IL-21 are less stringent following acute infections; however, in the absence of IL-21, the capacity of CD8 T cells to attain the polyfunctional trait of IL-2 production is consistently reduced during both the effector and memory phases. This is further supported by in vitro studies showing that the addition of IL-21 promotes the differentiation of IL-2–producing CD8 T cells. Although the generation of memory CD8 T cells, which are capable of mounting protective recall responses, proceeds independently of IL-21, we demonstrate that IL-21 does function to support secondary responses, especially under competitive conditions. Collectively, these studies highlight the potential roles of IL-21 in determining the quality of CD8 T cell responses postinfection." @default.
• W2148358987 created "2016-06-24" @default.
• W2148358987 creator A5020208600 @default.
• W2148358987 creator A5086807976 @default.
• W2148358987 creator A5088471079 @default.
• W2148358987 date "2010-10-15" @default.
• W2148358987 modified "2023-09-27" @default.
• W2148358987 title "IL-21 Deficiency Influences CD8 T Cell Quality and Recall Responses following an Acute Viral Infection" @default.
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• W2148358987 doi "https://doi.org/10.4049/jimmunol.1001032" @default.
• W2148358987 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2950881" @default.
• W2148358987 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20844201" @default.
• W2148358987 hasPublicationYear "2010" @default.
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