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• W2148362975 abstract "Many studies have reported that microRNA-21 (miR-21) mihght predict the survival outcome in non-small cell lung cancers (NSCLCs) but the opposite opinion has also been expressed. The aim of this study was to summarize the evidence for a prognostic role of miR-21.All the eligible studies was searched by Medline and EMBASE and patients' clinical characteristics and survival outcome were extracted. Then a meta-analysis was performed to clarify the prognostic role of the miR-21 expression in different subgroups.A total of 8 eligible articles were yielded covering survival outcomes or clinical characteristics. The combined hazard ratio (HR) and 95% confidence interval (95% CI) for overall survival (OS) was 2.19 [0.76, 6.30], while the combined HR (95% CI) of Asian group for OS had a significant result, 5.49 [2.46, 12.27]. The combined HR (95% CI) for recurrence free survival or disease free survival (RFS/DFS) was 2.31 [1.52, 3.49]. Odds ratios (ORs) showed that the miR-21 expression was associated with lymph node status and histological type.miR-21 expression could predict the prognostic outcome of NSCLC in Asians, despite some deficiencies in the study data." @default.
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• W2148362975 date "2012-05-30" @default.
• W2148362975 modified "2023-10-14" @default.
• W2148362975 title "Prognostic Role of MicroRNA-21 in Non-small Cell Lung Cancer: a Meta-analysis" @default.
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• W2148362975 doi "https://doi.org/10.7314/apjcp.2012.13.5.2329" @default.
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