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- W2148365268 abstract "Abstract Short‐term information retention is crucial for information processing in the brain. It has long been suggested that the hippocampal CA3 region is able to support short‐term information retention through persistent neural firing. Theoretical studies have shown that this persistent firing can be supported by abundant excitatory recurrent connections in CA3. However, it remains unclear whether individual cells can support persistent firing. In this study, using in vitro whole‐cell patch‐clamp recordings in a rat hippocampal slice preparation, we show that hippocampal CA3 pyramidal cells support persistent firing under perfusion of the cholinergic agonist carbachol (10 μ m ). Furthermore, in contrast to earlier theoretical studies, this persistent firing is independent of ionotropic glutamatergic synaptic transmission and is supported by the calcium‐activated non‐selective cationic current. Because cholinergic receptor activation is crucial for short‐term memory tasks, persistent firing in individual cells may support short‐term information retention in the hippocampal CA3 region." @default.
- W2148365268 created "2016-06-24" @default.
- W2148365268 creator A5018631939 @default.
- W2148365268 creator A5045307668 @default.
- W2148365268 date "2013-05-08" @default.
- W2148365268 modified "2023-10-04" @default.
- W2148365268 title "Persistent firing supported by an intrinsic cellular mechanism in hippocampal CA3 pyramidal cells" @default.
- W2148365268 cites W138817596 @default.
- W2148365268 cites W146465976 @default.
- W2148365268 cites W1820904250 @default.
- W2148365268 cites W1944255113 @default.
- W2148365268 cites W1964645045 @default.
- W2148365268 cites W1966069671 @default.
- W2148365268 cites W1969023217 @default.
- W2148365268 cites W1969134342 @default.
- W2148365268 cites W1973606828 @default.
- W2148365268 cites W1975307569 @default.
- W2148365268 cites W1976594854 @default.
- W2148365268 cites W1977529993 @default.
- W2148365268 cites W1979173289 @default.
- W2148365268 cites W1986882279 @default.
- W2148365268 cites W1987639493 @default.
- W2148365268 cites W1988831155 @default.
- W2148365268 cites W1989047179 @default.
- W2148365268 cites W1992995286 @default.
- W2148365268 cites W199485882 @default.
- W2148365268 cites W2004974848 @default.
- W2148365268 cites W2005989201 @default.
- W2148365268 cites W2006602134 @default.
- W2148365268 cites W2006909079 @default.
- W2148365268 cites W2008936540 @default.
- W2148365268 cites W2010258495 @default.
- W2148365268 cites W2011114708 @default.
- W2148365268 cites W2013089722 @default.
- W2148365268 cites W2016261700 @default.
- W2148365268 cites W2023148260 @default.
- W2148365268 cites W2023156816 @default.
- W2148365268 cites W2023699349 @default.
- W2148365268 cites W2025559018 @default.
- W2148365268 cites W2027415025 @default.
- W2148365268 cites W2036615793 @default.
- W2148365268 cites W2036773579 @default.
- W2148365268 cites W2043564875 @default.
- W2148365268 cites W2044682977 @default.
- W2148365268 cites W2045840985 @default.
- W2148365268 cites W2048024998 @default.
- W2148365268 cites W2048063182 @default.
- W2148365268 cites W2049842417 @default.
- W2148365268 cites W2052515926 @default.
- W2148365268 cites W2053389780 @default.
- W2148365268 cites W2059746581 @default.
- W2148365268 cites W2060163190 @default.
- W2148365268 cites W2060244382 @default.
- W2148365268 cites W2061499533 @default.
- W2148365268 cites W2061530596 @default.
- W2148365268 cites W2067286874 @default.
- W2148365268 cites W2071290167 @default.
- W2148365268 cites W2072071056 @default.
- W2148365268 cites W2073055671 @default.
- W2148365268 cites W2073279884 @default.
- W2148365268 cites W2076735150 @default.
- W2148365268 cites W2081490004 @default.
- W2148365268 cites W2082087376 @default.
- W2148365268 cites W2083922453 @default.
- W2148365268 cites W2085401913 @default.
- W2148365268 cites W2089531958 @default.
- W2148365268 cites W2101491694 @default.
- W2148365268 cites W2102721930 @default.
- W2148365268 cites W2103769608 @default.
- W2148365268 cites W2114502694 @default.
- W2148365268 cites W2117586879 @default.
- W2148365268 cites W2119051448 @default.
- W2148365268 cites W2123383560 @default.
- W2148365268 cites W2125706064 @default.
- W2148365268 cites W2125901663 @default.
- W2148365268 cites W2126561217 @default.
- W2148365268 cites W2127372311 @default.
- W2148365268 cites W2133208671 @default.
- W2148365268 cites W2133450681 @default.
- W2148365268 cites W2137700545 @default.
- W2148365268 cites W2149422514 @default.
- W2148365268 cites W2151125940 @default.
- W2148365268 cites W2155096497 @default.
- W2148365268 cites W2156213559 @default.
- W2148365268 cites W2156985666 @default.
- W2148365268 cites W2160585478 @default.
- W2148365268 cites W2162712079 @default.
- W2148365268 cites W2165510067 @default.
- W2148365268 cites W2167372515 @default.
- W2148365268 cites W2170669156 @default.
- W2148365268 cites W2254939070 @default.
- W2148365268 cites W4235691221 @default.
- W2148365268 cites W4247128360 @default.
- W2148365268 cites W4248376241 @default.
- W2148365268 cites W5055497 @default.
- W2148365268 doi "https://doi.org/10.1111/ejn.12236" @default.
- W2148365268 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23651161" @default.
- W2148365268 hasPublicationYear "2013" @default.