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- W2148403453 abstract "Grade 4 neutropenia is associated with an increased risk of infections. Low-dose lenograstim at 13 million units per day is commonly used in children undergoing cytotoxic chemotherapy. The present pilot study investigated the effect of prophylactic low-dose lenograstim (13 million units of lenograstim, GranozyteR, Sanofi-Aventis Pharma) in 20 patients with breast cancer who received (neo) adjuvant (F)EC (5-fluorouracil-epirubicin-cyclophosphamide) chemotherapy on days 3 to 10 of the chemotherapy cycle. All of them had experienced nadirs of absolute neutrophil counts (ANC) .05). Grade 4 neutropenia occurred in 4% of lenograstim-supported cycles only. Antibiotics were necessary in 4% of cycles only. Grade 1 or 2 bone pain was recorded in 14%. In conclusion, an economic regimen of prophylactic low-dose lenograstim, administered at 13 million units per day over 8 days, has been demonstrated to maintain neutrophil levels above the critical level and thus to prevent grade 4 neutropenia. Trials comparing this regimen with pegylated G-CSF seem warranted." @default.
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- W2148403453 date "2014-12-30" @default.
- W2148403453 modified "2023-10-01" @default.
- W2148403453 title "Prophylactic low-dose G-CSF in patients with breast cancer experiencing grade 4 neutropenia during their previous (neo-) adjuvant (F)EC-chemotherapy cycle: Results of a pilot study" @default.
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- W2148403453 doi "https://doi.org/10.5430/jst.v4n4p47" @default.
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