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• W2148425220 abstract "Anisotropic gold nanorods provide a convenient combination of properties, such as tunability of plasmon resonances and strong extinction cross sections in the near-infrared to red spectral region. These properties have created significant interest in the development of antibody conjugation methods for synthesis of targeted nanorods for a number of biomedical applications, including molecular specific imaging and therapy. Previously published conjugation approaches have achieved molecular specificity. However, the current conjugation methods have several downsides including low stability and potential cytotoxicity of bioconjugates that are produced by electrostatic interactions, as well as lack of control over antibody orientation during covalent conjugation. Here we addressed these shortcomings by introducing directional antibody conjugation to the gold nanorod surface. The directional conjugation is achieved through the carbohydrate moiety, which is located on one of the heavy chains of the Fc portion of most antibodies. The carbohydrate is oxidized under mild conditions to a hydrazide reactive aldehyde group. Then, a heterofunctional linker with hydrazide and dithiol groups is used to attach antibodies to gold nanorods. The directional conjugation approach was characterized using electron microscopy, zeta potential, and extinction spectra. We also determined spectral changes associated with nanorod aggregation; these spectral changes can be used as a convenient quality control of nanorod bioconjugates. Molecular specificity of the synthesized antibody targeted nanorods was demonstrated using hyperspectral, optical and photoacoustic imaging of cancer cell culture models. Additionally, we observed characteristic changes in optical spectra of molecular specific nanorods after their interactions with cancer cells; the observed spectral signatures can be explored for sensitive cancer detection." @default.
• W2148425220 created "2016-06-24" @default.
• W2148425220 creator A5005161326 @default.
• W2148425220 creator A5016266577 @default.
• W2148425220 creator A5046383892 @default.
• W2148425220 creator A5055136891 @default.
• W2148425220 creator A5065940442 @default.
• W2148425220 date "2013-05-14" @default.
• W2148425220 modified "2023-10-17" @default.
• W2148425220 title "Conjugation of Antibodies to Gold Nanorods through Fc Portion: Synthesis and Molecular Specific Imaging" @default.
• W2148425220 cites W1540220148 @default.
• W2148425220 cites W1657073637 @default.
• W2148425220 cites W1964564038 @default.
• W2148425220 cites W1966226618 @default.
• W2148425220 cites W1973714168 @default.
• W2148425220 cites W1978369328 @default.
• W2148425220 cites W1980795348 @default.
• W2148425220 cites W1981993332 @default.
• W2148425220 cites W1982700260 @default.
• W2148425220 cites W1988171375 @default.
• W2148425220 cites W1989822610 @default.
• W2148425220 cites W1992272938 @default.
• W2148425220 cites W1992685120 @default.
• W2148425220 cites W1993013498 @default.
• W2148425220 cites W1994844156 @default.
• W2148425220 cites W1995734581 @default.
• W2148425220 cites W1998383751 @default.
• W2148425220 cites W2001851003 @default.
• W2148425220 cites W2011272615 @default.
• W2148425220 cites W2014012073 @default.
• W2148425220 cites W2014077561 @default.
• W2148425220 cites W2016879924 @default.
• W2148425220 cites W2025295644 @default.
• W2148425220 cites W2028774780 @default.
• W2148425220 cites W2029804518 @default.
• W2148425220 cites W2030964111 @default.
• W2148425220 cites W2032654453 @default.
• W2148425220 cites W2034538920 @default.
• W2148425220 cites W2036969572 @default.
• W2148425220 cites W2038844459 @default.
• W2148425220 cites W2039984490 @default.
• W2148425220 cites W2040294604 @default.
• W2148425220 cites W2043009832 @default.
• W2148425220 cites W2044127957 @default.
• W2148425220 cites W2046078039 @default.
• W2148425220 cites W2047620771 @default.
• W2148425220 cites W2048912747 @default.
• W2148425220 cites W2053194254 @default.
• W2148425220 cites W2054279570 @default.
• W2148425220 cites W2056927092 @default.
• W2148425220 cites W2060866429 @default.
• W2148425220 cites W2062323761 @default.
• W2148425220 cites W2063172840 @default.
• W2148425220 cites W2065822072 @default.
• W2148425220 cites W2066332011 @default.
• W2148425220 cites W2067203318 @default.
• W2148425220 cites W2068389027 @default.
• W2148425220 cites W2071224672 @default.
• W2148425220 cites W2075244150 @default.
• W2148425220 cites W2076719191 @default.
• W2148425220 cites W2076895064 @default.
• W2148425220 cites W2078517045 @default.
• W2148425220 cites W2080376276 @default.
• W2148425220 cites W2080828932 @default.
• W2148425220 cites W2084834913 @default.
• W2148425220 cites W2085105678 @default.
• W2148425220 cites W2086696748 @default.
• W2148425220 cites W2086754387 @default.
• W2148425220 cites W2089134007 @default.
• W2148425220 cites W2090110748 @default.
• W2148425220 cites W2093279818 @default.
• W2148425220 cites W2104979069 @default.
• W2148425220 cites W2108611432 @default.
• W2148425220 cites W2109681676 @default.
• W2148425220 cites W2109791954 @default.
• W2148425220 cites W2116314192 @default.
• W2148425220 cites W2118997868 @default.
• W2148425220 cites W2127095945 @default.
• W2148425220 cites W2129166766 @default.
• W2148425220 cites W2129569338 @default.
• W2148425220 cites W2132590121 @default.
• W2148425220 cites W2138497290 @default.
• W2148425220 cites W2139279857 @default.
• W2148425220 cites W2143833247 @default.
• W2148425220 cites W2148694942 @default.
• W2148425220 cites W2148737592 @default.
• W2148425220 cites W2151665064 @default.
• W2148425220 cites W2152913593 @default.
• W2148425220 cites W2157443813 @default.
• W2148425220 cites W2160045751 @default.
• W2148425220 cites W2162034088 @default.
• W2148425220 cites W2167737820 @default.
• W2148425220 cites W2169119609 @default.
• W2148425220 cites W2334209708 @default.
• W2148425220 cites W4234497299 @default.
• W2148425220 doi "https://doi.org/10.1021/bc3004815" @default.
• W2148425220 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3891905" @default.
• W2148425220 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23631707" @default.

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