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- W2148429988 abstract "The hepatic peptide is a critical regulator of iron metabolism and inflammation. In this (first) study of post-operative hepcidin levels in patients undergoing liver transplantation we show that post-operative serum hepcidin levels identify patients with severe preservation/reperfusion injury and predict early graft dysfunction following liver transplantation. Methods: Serial serum hepcidin levels were measured daily by SELDI-TOFmass spectrometry (using stable isotope labelled hepcidin as internal standard) in 11 patients after liver transplantation. Liver biopsies (T0) were taken at the time of operation in 9/11 patients. Patient outcomes were correlated with clinicopathological results. Results: Five (5/11) patients had poor graft function after transplantation (graft cholestasis, elevated PT time and AST); these patients were more likely to have moderate/severe preservation injury on TO biopsy than patients with normal graft function and more likely to have received a liver from a nonheart beating than a heart-beating donor (3/5 vs 1/7). One patient with graft dysfunction was not biopsied. Whilst there was no difference in hepcidin values between the 2 groups at the time of transplantation (90 vs 76ng/ml p=0.68), the 5 patients with poor graft function had significantly higher hepcidin levels on the third day 3 post-transplantation compared to the 6 patients with mild preservation/reperfusion injury (Mean 135 (91-179) vs.39 (1761) ng/ml, p<0.01 ANOVA). Hepcidin rose by 39% between day 1 and 3 in the poor graft function group but fell by 49% in the group with normal function. Day 3 hepcidin rise anticipated graft cholestasis in those with severe preservation injury and did not correlate with AST or CRP. There was no difference in the two groups regarding age, cold ischaemic time, mean length of ITU stay or rate of septic complications. Conclusion: Serum hepcidin may be a better determinant of graft dysfunction post liver transplant than AST or CRP." @default.
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- W2148429988 date "2010-05-01" @default.
- W2148429988 modified "2023-09-24" @default.
- W2148429988 title "M1023 Pre-Transplant Factors Influencing Indication for Simultaneous Liver-Kidney Transplantation" @default.
- W2148429988 doi "https://doi.org/10.1016/s0016-5085(10)63797-3" @default.
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