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- W2148445344 abstract "Hypoxia is a hallmark of solid cancers and triggers the transcription of genes responsible for cell survival. The transcription factor Hypoxia-Inducible Factor 1 (HIF-1) is a key regulator in this response and frequently activated in human cancer. HIF-1 activation is associated with tumor aggressiveness and poor clinical outcome and, therefore, may provide an attractive therapeutic target. Here we provide a novel approach for HIF-1 targeted therapy using single-domain llama antibodies directed against the HIF-1alpha oxygen dependent degradation domain which encompass the N-terminal transactivation domain. Conditional expression of HIF intrabodies in mammalian cells interfered with binding to pVHL and inhibited hypoxia induced activation of endogenous target genes. Inducible intrabody targeting is a highly specific strategy for temporal protein inactivation and may have applications for disease treatment." @default.
- W2148445344 created "2016-06-24" @default.
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- W2148445344 date "2008-01-01" @default.
- W2148445344 modified "2023-09-27" @default.
- W2148445344 title "Conditional inactivation of HIF-1 using intrabodies." @default.
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- W2148445344 doi "https://doi.org/10.3233/clo-2008-0442" @default.
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