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- W2148476801 abstract "Growth factor-mediated proliferation and self-renewal maintain tissue-specific stem cells and are frequently dysregulated in cancers. Platelet-derived growth factor (PDGF) ligands and receptors (PDGFRs) are commonly overexpressed in gliomas and initiate tumors, as proven in genetically engineered models. While PDGFRα alterations inform intertumoral heterogeneity toward a proneural glioblastoma (GBM) subtype, we interrogated the role of PDGFRs in intratumoral GBM heterogeneity. We found that PDGFRα is expressed only in a subset of GBMs, while PDGFRβ is more commonly expressed in tumors but is preferentially expressed by self-renewing tumorigenic GBM stem cells (GSCs). Genetic or pharmacological targeting of PDGFRβ (but not PDGFRα) attenuated GSC self-renewal, survival, tumor growth, and invasion. PDGFRβ inhibition decreased activation of the cancer stem cell signaling node STAT3, while constitutively active STAT3 rescued the loss of GSC self-renewal caused by PDGFRβ targeting. In silico survival analysis demonstrated that PDGFRB informed poor prognosis, while PDGFRA was a positive prognostic factor. Our results may explain mixed clinical responses of anti-PDGFR-based approaches and suggest the need for integration of models of cancer as an organ system into development of cancer therapies." @default.
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- W2148476801 date "2012-06-01" @default.
- W2148476801 modified "2023-10-05" @default.
- W2148476801 title "Platelet-derived growth factor receptors differentially inform intertumoral and intratumoral heterogeneity" @default.
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- W2148476801 cites W1971046933 @default.
- W2148476801 cites W1972700706 @default.
- W2148476801 cites W1978271705 @default.
- W2148476801 cites W1986034385 @default.
- W2148476801 cites W1989891384 @default.
- W2148476801 cites W1992301683 @default.
- W2148476801 cites W1995104464 @default.
- W2148476801 cites W1997664696 @default.
- W2148476801 cites W1999851814 @default.
- W2148476801 cites W2001544973 @default.
- W2148476801 cites W2007897471 @default.
- W2148476801 cites W2015338496 @default.
- W2148476801 cites W2020231800 @default.
- W2148476801 cites W2020510601 @default.
- W2148476801 cites W2025183726 @default.
- W2148476801 cites W2031749466 @default.
- W2148476801 cites W2033480740 @default.
- W2148476801 cites W2038198824 @default.
- W2148476801 cites W2041617965 @default.
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- W2148476801 cites W2055561480 @default.
- W2148476801 cites W2058322957 @default.
- W2148476801 cites W2060770596 @default.
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- W2148476801 cites W2062165914 @default.
- W2148476801 cites W2062672647 @default.
- W2148476801 cites W2064471338 @default.
- W2148476801 cites W2064578746 @default.
- W2148476801 cites W2068251212 @default.
- W2148476801 cites W2070705072 @default.
- W2148476801 cites W2079422313 @default.
- W2148476801 cites W2090327423 @default.
- W2148476801 cites W2096992832 @default.
- W2148476801 cites W2098588666 @default.
- W2148476801 cites W2100088344 @default.
- W2148476801 cites W2102085111 @default.
- W2148476801 cites W2102626211 @default.
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- W2148476801 cites W2112236191 @default.
- W2148476801 cites W2112703519 @default.
- W2148476801 cites W2113942802 @default.
- W2148476801 cites W2117692326 @default.
- W2148476801 cites W2121625674 @default.
- W2148476801 cites W2123509170 @default.
- W2148476801 cites W2124078079 @default.
- W2148476801 cites W2124224257 @default.
- W2148476801 cites W2131403504 @default.
- W2148476801 cites W2137020659 @default.
- W2148476801 cites W2139520473 @default.
- W2148476801 cites W2141900493 @default.
- W2148476801 cites W2143308874 @default.
- W2148476801 cites W2143580838 @default.
- W2148476801 cites W2145925994 @default.
- W2148476801 cites W2151335185 @default.
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- W2148476801 doi "https://doi.org/10.1101/gad.193565.112" @default.
- W2148476801 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3371412" @default.
- W2148476801 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22661233" @default.
- W2148476801 hasPublicationYear "2012" @default.
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