FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2148486363> ?p ?o ?g. }

• W2148486363 endingPage "8330" @default.
• W2148486363 startingPage "8320" @default.
• W2148486363 abstract "Synaptic activation in the presence of competitive (D,L-APV,CNQX) and noncompetitive (MK-801,GYKI-52466) ionotropic glutamate receptor antagonists induced fast (10-90% rise time of 15-30 msec) postsynaptic responses in CA3 pyramidal neurons from acute and cultured hippocampal slices. Postsynaptic currents were studied extensively in slice cultures, and displayed a linear current-voltage relationship, with a reversal potential between 0 mV and +10 mV, suggesting the activation of a nonselective cationic conductance. Inhibition of the GTPase cycle by intracellular perfusion with the nonhydrolyzable analog of GDP, GDP beta S, blocked the fast postsynaptic responses evoked in ionotropic antagonists, as well as baclofen-mediated outward K+ currents, known to be mediated by G protein-coupled GABAB receptors. Intracellular perfusion with GDP beta S did not affect the AMPA/kainate component of the synaptic currents. Irreversible activation of G proteins by intracellular perfusion with the nonhydrolyzable analog of GTP, GMP-PNP, occluded the baclofen responses, and evoked an inward current, consistent with the synaptically mediated conductance. Incubation of the slice cultures in pertussis toxin for 72 hr blocked baclofen-induced outward K+ currents, while the fast postsynaptic currents remained. The metabotropic glutamate receptor (mGluR) agonists 1S,3R-ACPD and 1S,3S-ACPD induced an inward current in the presence of the ionotropic antagonists, and occluded the fast EPSCs. The fast EPSCs were partially blocked by the mGluR antagonists L-AP3 and (+)MCPG, but there was differential antagonists sensitivity in two pathways stimulated (CA3 stratum radiatum vs CA3 stratum oriens). These data suggest that fast postsynaptic responses evoked in the presence of ionotropic glutamate receptor antagonists are mediated by G protein-coupled mGluRs linked to nonselective cationic channels." @default.
• W2148486363 created "2016-06-24" @default.
• W2148486363 creator A5012612572 @default.
• W2148486363 creator A5051364874 @default.
• W2148486363 creator A5062392717 @default.
• W2148486363 date "1995-12-01" @default.
• W2148486363 modified "2023-10-17" @default.
• W2148486363 title "G protein-coupled receptors mediate a fast excitatory postsynaptic current in CA3 pyramidal neurons in hippocampal slices" @default.
• W2148486363 cites W1503789839 @default.
• W2148486363 cites W1515479627 @default.
• W2148486363 cites W1548031896 @default.
• W2148486363 cites W1561097263 @default.
• W2148486363 cites W1564717701 @default.
• W2148486363 cites W1573974516 @default.
• W2148486363 cites W1582905488 @default.
• W2148486363 cites W1590954967 @default.
• W2148486363 cites W1735016861 @default.
• W2148486363 cites W1762877386 @default.
• W2148486363 cites W1780057589 @default.
• W2148486363 cites W1823231128 @default.
• W2148486363 cites W1963963391 @default.
• W2148486363 cites W1965221716 @default.
• W2148486363 cites W1965544923 @default.
• W2148486363 cites W1969357031 @default.
• W2148486363 cites W1970161814 @default.
• W2148486363 cites W1970992446 @default.
• W2148486363 cites W1972183007 @default.
• W2148486363 cites W1977423896 @default.
• W2148486363 cites W1979381437 @default.
• W2148486363 cites W1979459483 @default.
• W2148486363 cites W1985001613 @default.
• W2148486363 cites W1988960741 @default.
• W2148486363 cites W1992064771 @default.
• W2148486363 cites W1992349983 @default.
• W2148486363 cites W1993835964 @default.
• W2148486363 cites W1995473597 @default.
• W2148486363 cites W1997727729 @default.
• W2148486363 cites W2000853989 @default.
• W2148486363 cites W2001330542 @default.
• W2148486363 cites W2002151621 @default.
• W2148486363 cites W2002500227 @default.
• W2148486363 cites W2003058141 @default.
• W2148486363 cites W2004668023 @default.
• W2148486363 cites W2005711621 @default.
• W2148486363 cites W2006144414 @default.
• W2148486363 cites W2007239691 @default.
• W2148486363 cites W2010428345 @default.
• W2148486363 cites W2012705798 @default.
• W2148486363 cites W2018701979 @default.
• W2148486363 cites W2019667433 @default.
• W2148486363 cites W2020425432 @default.
• W2148486363 cites W2020461481 @default.
• W2148486363 cites W2024328209 @default.
• W2148486363 cites W2029692406 @default.
• W2148486363 cites W2034797890 @default.
• W2148486363 cites W2035115219 @default.
• W2148486363 cites W2035245157 @default.
• W2148486363 cites W2036495604 @default.
• W2148486363 cites W2038678229 @default.
• W2148486363 cites W2042550512 @default.
• W2148486363 cites W2049230063 @default.
• W2148486363 cites W2050140782 @default.
• W2148486363 cites W2050231827 @default.
• W2148486363 cites W2052673887 @default.
• W2148486363 cites W2055137643 @default.
• W2148486363 cites W2056526260 @default.
• W2148486363 cites W2057519706 @default.
• W2148486363 cites W2057537207 @default.
• W2148486363 cites W2059034458 @default.
• W2148486363 cites W2059170083 @default.
• W2148486363 cites W2062957466 @default.
• W2148486363 cites W2066156887 @default.
• W2148486363 cites W2066439059 @default.
• W2148486363 cites W2067317040 @default.
• W2148486363 cites W2069873922 @default.
• W2148486363 cites W2071230662 @default.
• W2148486363 cites W2073772517 @default.
• W2148486363 cites W2075010053 @default.
• W2148486363 cites W2078935283 @default.
• W2148486363 cites W2079054696 @default.
• W2148486363 cites W2080667065 @default.
• W2148486363 cites W2080875376 @default.
• W2148486363 cites W2086894916 @default.
• W2148486363 cites W2088912528 @default.
• W2148486363 cites W2090501101 @default.
• W2148486363 cites W2091837097 @default.
• W2148486363 cites W2092093968 @default.
• W2148486363 cites W2106016755 @default.
• W2148486363 cites W2111157870 @default.
• W2148486363 cites W2129933607 @default.
• W2148486363 cites W2132198678 @default.
• W2148486363 cites W2149201522 @default.
• W2148486363 cites W2150728457 @default.
• W2148486363 cites W2161584310 @default.
• W2148486363 cites W2162213293 @default.
• W2148486363 cites W2162754411 @default.
• W2148486363 cites W2164293375 @default.
• W2148486363 cites W2169370057 @default.

• next