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• W2148491113 startingPage "1036" @default.
• W2148491113 abstract "Proteasome inhibitors are useful in the treatment of cancer. Recently, we found a new proteasome inhibitor, TP-110, derived from tyropeptin A produced by Kitasatospora sp. Here we report that TP-110 induces apoptosis in human prostate cancer PC-3 cells. TP-110 showed strong cytotoxicity to PC-3 cells (IC50=0.05 μm). It increased the number of cells in the G2-M phase and increased the accumulated amounts of the p21 and p27 proteins, which are negative regulators of cell cycle progression. Furthermore, it induced apoptosis along with chromatin condensation and DNA fragmentation in PC-3 cells, and TP-110-induced apoptosis appeared to be associated with caspase activation. Additionally, TP-110 inhibited not only the degradation of IκB and the nuclear translocation of nuclear factor-κB (NF-κB), but also the DNA binding activity of NF-κB. These results indicate that TP-110 shows a strong growth inhibition and apoptosis in PC-3 cells." @default.
• W2148491113 created "2016-06-24" @default.
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• W2148491113 creator A5064054143 @default.
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• W2148491113 date "2007-04-23" @default.
• W2148491113 modified "2023-10-18" @default.
• W2148491113 title "A New Proteasome Inhibitor, TP-110, Induces Apoptosis in Human Prostate Cancer PC-3 Cells" @default.
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• W2148491113 doi "https://doi.org/10.1271/bbb.60697" @default.
• W2148491113 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17420589" @default.
• W2148491113 hasPublicationYear "2007" @default.
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