Matches in SemOpenAlex for { <https://semopenalex.org/work/W2148514480> ?p ?o ?g. }
- W2148514480 endingPage "76" @default.
- W2148514480 startingPage "67" @default.
- W2148514480 abstract "In many countries, the protease inhibitor (SERPINA1) PI*S allele is more common than PI*Z, the allele responsible for most cases of chronic obstructive pulmonary disease (COPD) due to severe alpha 1-antitrypsin deficiency. However, the risk of COPD due to the PI*S allele is not clear. The current authors located studies that addressed the risk of COPD or measured lung function in individuals with the PI SZ, PI MS and PI SS genotypes. A separate meta-analysis for each genotype was performed. Aggregating data from six studies, the odds ratio (OR) for COPD in PI SZ compound heterozygotes compared with PI MM (normal) individuals was significantly increased at 3.26 (95% confidence intervals (CI): 1.24–8.57). In 17 cross-sectional and case-control studies, the OR for COPD in PI MS heterozygotes was 1.19 (95%CI: 1.02–1.38). However, PI MS genotype was not associated with COPD risk after correcting for smoking. Furthermore, mean forced expiratory volume in one second, a measure of airflow obstruction and a defining feature of COPD, did not differ between PI MS and PI MM individuals. There were not enough cases to summarise the risk of COPD in PI SS homozygotes. In conclusion, the results show that the PI SZ genotype is a significant risk factor for chronic obstructive pulmonary disease. The risk of chronic obstructive pulmonary disease due to the PI MS genotype is not substantially elevated." @default.
- W2148514480 created "2016-06-24" @default.
- W2148514480 creator A5031205333 @default.
- W2148514480 creator A5035524361 @default.
- W2148514480 creator A5059655447 @default.
- W2148514480 creator A5064234700 @default.
- W2148514480 creator A5079728437 @default.
- W2148514480 creator A5091853347 @default.
- W2148514480 date "2005-07-01" @default.
- W2148514480 modified "2023-09-27" @default.
- W2148514480 title "The protease inhibitor PI*S allele and COPD: a meta-analysis" @default.
- W2148514480 cites W1503586932 @default.
- W2148514480 cites W1527850385 @default.
- W2148514480 cites W1546422497 @default.
- W2148514480 cites W1550656080 @default.
- W2148514480 cites W1551151694 @default.
- W2148514480 cites W1749634611 @default.
- W2148514480 cites W1759997098 @default.
- W2148514480 cites W1775100530 @default.
- W2148514480 cites W1780955027 @default.
- W2148514480 cites W1788061071 @default.
- W2148514480 cites W1823471161 @default.
- W2148514480 cites W1834318348 @default.
- W2148514480 cites W1850699359 @default.
- W2148514480 cites W1858190044 @default.
- W2148514480 cites W1886671902 @default.
- W2148514480 cites W1900568776 @default.
- W2148514480 cites W1903510379 @default.
- W2148514480 cites W1916622131 @default.
- W2148514480 cites W1940022121 @default.
- W2148514480 cites W1951714335 @default.
- W2148514480 cites W1974163309 @default.
- W2148514480 cites W1976616423 @default.
- W2148514480 cites W1980045807 @default.
- W2148514480 cites W1980383106 @default.
- W2148514480 cites W1982696431 @default.
- W2148514480 cites W1984115516 @default.
- W2148514480 cites W1987554599 @default.
- W2148514480 cites W1989579667 @default.
- W2148514480 cites W1989983631 @default.
- W2148514480 cites W1992992053 @default.
- W2148514480 cites W2004796389 @default.
- W2148514480 cites W2013911556 @default.
- W2148514480 cites W2018297210 @default.
- W2148514480 cites W2018363999 @default.
- W2148514480 cites W2018550174 @default.
- W2148514480 cites W2019568714 @default.
- W2148514480 cites W2019785012 @default.
- W2148514480 cites W2022327803 @default.
- W2148514480 cites W2025313479 @default.
- W2148514480 cites W2026163003 @default.
- W2148514480 cites W2028228119 @default.
- W2148514480 cites W2031321641 @default.
- W2148514480 cites W2032703463 @default.
- W2148514480 cites W2033471766 @default.
- W2148514480 cites W2033902278 @default.
- W2148514480 cites W2034334718 @default.
- W2148514480 cites W2038789658 @default.
- W2148514480 cites W2044854028 @default.
- W2148514480 cites W2045616259 @default.
- W2148514480 cites W2046211792 @default.
- W2148514480 cites W2053003513 @default.
- W2148514480 cites W2053291313 @default.
- W2148514480 cites W2061081826 @default.
- W2148514480 cites W2062796075 @default.
- W2148514480 cites W2063431532 @default.
- W2148514480 cites W2063945782 @default.
- W2148514480 cites W2064985248 @default.
- W2148514480 cites W2065379365 @default.
- W2148514480 cites W2066305431 @default.
- W2148514480 cites W2071493384 @default.
- W2148514480 cites W2072731203 @default.
- W2148514480 cites W2074863064 @default.
- W2148514480 cites W2075399913 @default.
- W2148514480 cites W2076156870 @default.
- W2148514480 cites W2077190511 @default.
- W2148514480 cites W2079906798 @default.
- W2148514480 cites W2080219626 @default.
- W2148514480 cites W2083230597 @default.
- W2148514480 cites W2084815235 @default.
- W2148514480 cites W2086055154 @default.
- W2148514480 cites W2086855674 @default.
- W2148514480 cites W2090422611 @default.
- W2148514480 cites W2093732736 @default.
- W2148514480 cites W2094431933 @default.
- W2148514480 cites W2097892565 @default.
- W2148514480 cites W2098263835 @default.
- W2148514480 cites W2100635037 @default.
- W2148514480 cites W2107328434 @default.
- W2148514480 cites W2112273739 @default.
- W2148514480 cites W2123616384 @default.
- W2148514480 cites W2127951128 @default.
- W2148514480 cites W2137240228 @default.
- W2148514480 cites W2137804258 @default.
- W2148514480 cites W2140218685 @default.
- W2148514480 cites W2145648281 @default.
- W2148514480 cites W2147049515 @default.
- W2148514480 cites W2155287678 @default.