FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2148544319> ?p ?o ?g. }

• W2148544319 abstract "Cell polarization is a fundamental process that underlies epithelial morphogenesis, cell motility, cell division and organogenesis. Loss of polarity predisposes tissues to developmental disorders and contributes to cancer progression. The formation and establishment of epithelial cell polarity is mediated by the cooperation of polarity protein complexes, namely the Crumbs, partitioning defective (Par) and Scribble complexes, with Rho family GTPases, including RhoA, Rac1 and Cdc42. The activation of different GTPases triggers distinct downstream signaling pathways to modulate protein-protein interactions and cytoskeletal remodeling. The spatio-temporal activation and inactivation of these small GTPases is tightly controlled by a complex interconnected network of different regulatory proteins, including guanine-nucleotide-exchange factors (GEFs), GTPase-activating proteins (GAPs), and guanine-nucleotide-dissociation inhibitors (GDIs). In this Commentary, we focus on current understanding on how polarity complexes interact with GEFs and GAPs to control the precise location and activation of Rho GTPases (Crumbs for RhoA, Par for Rac1, and Scribble for Cdc42) to promote apical-basal polarization in mammalian epithelial cells. The mutual exclusion of GTPase activities, especially that of RhoA and Rac1, which is well established, provides a mechanism through which polarity complexes that act through distinct Rho GTPases function as cellular rheostats to fine-tune specific downstream pathways to differentiate and preserve the apical and basolateral domains. This article is part of a Minifocus on Establishing polarity." @default.
• W2148544319 created "2016-06-24" @default.
• W2148544319 creator A5000491993 @default.
• W2148544319 creator A5019065224 @default.
• W2148544319 creator A5084752300 @default.
• W2148544319 date "2014-01-01" @default.
• W2148544319 modified "2023-10-18" @default.
• W2148544319 title "Establishment of epithelial polarity – GEF who's minding the GAP?" @default.
• W2148544319 cites W1233997596 @default.
• W2148544319 cites W1521774859 @default.
• W2148544319 cites W1560056935 @default.
• W2148544319 cites W1574816972 @default.
• W2148544319 cites W1595817144 @default.
• W2148544319 cites W1646135266 @default.
• W2148544319 cites W1774057457 @default.
• W2148544319 cites W1898333961 @default.
• W2148544319 cites W1964073548 @default.
• W2148544319 cites W1964823699 @default.
• W2148544319 cites W1965064672 @default.
• W2148544319 cites W1965410387 @default.
• W2148544319 cites W1965912855 @default.
• W2148544319 cites W1966032423 @default.
• W2148544319 cites W1966398993 @default.
• W2148544319 cites W1967999176 @default.
• W2148544319 cites W1969200465 @default.
• W2148544319 cites W1969417219 @default.
• W2148544319 cites W1971964944 @default.
• W2148544319 cites W1972204116 @default.
• W2148544319 cites W1972644970 @default.
• W2148544319 cites W1974475510 @default.
• W2148544319 cites W1975338046 @default.
• W2148544319 cites W1976577398 @default.
• W2148544319 cites W1977245174 @default.
• W2148544319 cites W1978934743 @default.
• W2148544319 cites W1979333716 @default.
• W2148544319 cites W1980398528 @default.
• W2148544319 cites W1980979311 @default.
• W2148544319 cites W1982097676 @default.
• W2148544319 cites W1983350492 @default.
• W2148544319 cites W1984024996 @default.
• W2148544319 cites W1985617800 @default.
• W2148544319 cites W1990188178 @default.
• W2148544319 cites W1990557148 @default.
• W2148544319 cites W1991254695 @default.
• W2148544319 cites W1992644684 @default.
• W2148544319 cites W1994404140 @default.
• W2148544319 cites W1994755074 @default.
• W2148544319 cites W1999064468 @default.
• W2148544319 cites W2000709179 @default.
• W2148544319 cites W2004071190 @default.
• W2148544319 cites W2004317905 @default.
• W2148544319 cites W2004434166 @default.
• W2148544319 cites W2004762438 @default.
• W2148544319 cites W2004921139 @default.
• W2148544319 cites W2006330673 @default.
• W2148544319 cites W2006688354 @default.
• W2148544319 cites W2007101096 @default.
• W2148544319 cites W2007352125 @default.
• W2148544319 cites W2009303644 @default.
• W2148544319 cites W2009671571 @default.
• W2148544319 cites W2009776121 @default.
• W2148544319 cites W2009843711 @default.
• W2148544319 cites W2010497270 @default.
• W2148544319 cites W2011776666 @default.
• W2148544319 cites W2012569825 @default.
• W2148544319 cites W2013044162 @default.
• W2148544319 cites W2013662588 @default.
• W2148544319 cites W2014665003 @default.
• W2148544319 cites W2014669694 @default.
• W2148544319 cites W2015207072 @default.
• W2148544319 cites W2016979375 @default.
• W2148544319 cites W2017923473 @default.
• W2148544319 cites W2018574900 @default.
• W2148544319 cites W2019137018 @default.
• W2148544319 cites W2019731805 @default.
• W2148544319 cites W2020234700 @default.
• W2148544319 cites W2021856025 @default.
• W2148544319 cites W2024222958 @default.
• W2148544319 cites W2024349959 @default.
• W2148544319 cites W2025383253 @default.
• W2148544319 cites W2025483613 @default.
• W2148544319 cites W2025896887 @default.
• W2148544319 cites W2026388532 @default.
• W2148544319 cites W2027448883 @default.
• W2148544319 cites W2028919524 @default.
• W2148544319 cites W2033555492 @default.
• W2148544319 cites W2034071612 @default.
• W2148544319 cites W2034696312 @default.
• W2148544319 cites W2035630698 @default.
• W2148544319 cites W2039075455 @default.
• W2148544319 cites W2040210675 @default.
• W2148544319 cites W2040435657 @default.
• W2148544319 cites W2040531646 @default.
• W2148544319 cites W2042111453 @default.
• W2148544319 cites W2043371279 @default.
• W2148544319 cites W2044319117 @default.
• W2148544319 cites W2045794384 @default.
• W2148544319 cites W2046013104 @default.
• W2148544319 cites W2046457668 @default.
• W2148544319 cites W2046587126 @default.

• next