FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2148564489> ?p ?o ?g. }

• W2148564489 endingPage "472" @default.
• W2148564489 startingPage "466" @default.
• W2148564489 abstract "Background Familial combined hyperlipidemia (FCHL) is a genetic form of dyslipidemia, which is characterized by an increased cardiovascular risk. The current study was conducted to investigate the relation of endothelial, inflammatory and fibrinolysis markers with the presence of hypertriglyceridemia and fatty liver in FCHL, in order to advance insight in their contribution to the cardiovascular risk profile. Materials and methods Key plasma markers of low-grade inflammation, endothelial dysfunction and fibrinolysis were measured in 38 hypertriglyceridemic FCHL patients and 38 age and sex-matched spouses. The presence of fatty liver was determined with ultrasound. Results hsCRP, vWF, PAI-1, tPA and tPA/PAI-1 complex levels were significantly higher in hypertriglyceridemic FCHL patients compared to spouses (p<0.05). Subsequent analyses revealed that these increased levels were confined to FCHL patients with the fatty liver phenotype (n=25). Only PAI-1 and tPA levels were also elevated in the hypertriglyceridemic FCHL patients without fatty liver (n=13). Of interest, 11 hypertriglyceridemic non-FCHL patients with the E2/E2 genotype displayed significantly lower PAI-1 levels when compared to the overall FCHL population (p=0.001), implicating a role for apolipoprotein E in the relation of PAI-1 with plasma triglycerides. Conclusion Markers of fibrinolysis were increased in all hypertriglyceridemic FCHL patients, whereas an increased state of endothelial dysfunction and inflammation was particularly observed in those hypertriglyceridemic FCHL patients who also have fatty liver. These results demonstrate the complex genesis of the unfavourable cardiovascular risk profile that is present in FCHL, and illustrate the potential risk of fatty liver above, and beyond hypertriglyceridemia per se." @default.
• W2148564489 created "2016-06-24" @default.
• W2148564489 creator A5005465284 @default.
• W2148564489 creator A5016620300 @default.
• W2148564489 creator A5023966597 @default.
• W2148564489 creator A5031265369 @default.
• W2148564489 creator A5034309539 @default.
• W2148564489 creator A5036306697 @default.
• W2148564489 creator A5049195131 @default.
• W2148564489 creator A5053372098 @default.
• W2148564489 creator A5059654966 @default.
• W2148564489 creator A5071471535 @default.
• W2148564489 creator A5080024907 @default.
• W2148564489 creator A5080447100 @default.
• W2148564489 date "2008-01-01" @default.
• W2148564489 modified "2023-09-26" @default.
• W2148564489 title "Plasma PAI-1 levels are independently related to fatty liver and hypertriglyceridemia in familial combined hyperlipidemia, involvement of apolipoprotein E" @default.
• W2148564489 cites W1969230739 @default.
• W2148564489 cites W1972981120 @default.
• W2148564489 cites W1972987363 @default.
• W2148564489 cites W1980407853 @default.
• W2148564489 cites W1981018347 @default.
• W2148564489 cites W1983181715 @default.
• W2148564489 cites W2003306047 @default.
• W2148564489 cites W2004177180 @default.
• W2148564489 cites W2020829821 @default.
• W2148564489 cites W2032430567 @default.
• W2148564489 cites W2032485049 @default.
• W2148564489 cites W2032500402 @default.
• W2148564489 cites W2033315471 @default.
• W2148564489 cites W2042024480 @default.
• W2148564489 cites W2067514854 @default.
• W2148564489 cites W2072793621 @default.
• W2148564489 cites W2074747274 @default.
• W2148564489 cites W2079695370 @default.
• W2148564489 cites W2081518650 @default.
• W2148564489 cites W2082964909 @default.
• W2148564489 cites W2090826122 @default.
• W2148564489 cites W2096259240 @default.
• W2148564489 cites W2105943776 @default.
• W2148564489 cites W2117974292 @default.
• W2148564489 cites W2130376019 @default.
• W2148564489 cites W2132555301 @default.
• W2148564489 cites W2132631426 @default.
• W2148564489 cites W2142179136 @default.
• W2148564489 cites W2142802148 @default.
• W2148564489 cites W2145819586 @default.
• W2148564489 cites W2154157771 @default.
• W2148564489 cites W2158087282 @default.
• W2148564489 cites W2158801660 @default.
• W2148564489 cites W2336672206 @default.
• W2148564489 cites W4298880694 @default.
• W2148564489 doi "https://doi.org/10.1016/j.thromres.2007.12.009" @default.
• W2148564489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18262228" @default.
• W2148564489 hasPublicationYear "2008" @default.
• W2148564489 type Work @default.
• W2148564489 sameAs 2148564489 @default.
• W2148564489 citedByCount "16" @default.
• W2148564489 countsByYear W21485644892012 @default.
• W2148564489 countsByYear W21485644892014 @default.
• W2148564489 countsByYear W21485644892015 @default.
• W2148564489 countsByYear W21485644892017 @default.
• W2148564489 countsByYear W21485644892020 @default.
• W2148564489 countsByYear W21485644892022 @default.
• W2148564489 countsByYear W21485644892023 @default.
• W2148564489 crossrefType "journal-article" @default.
• W2148564489 hasAuthorship W2148564489A5005465284 @default.
• W2148564489 hasAuthorship W2148564489A5016620300 @default.
• W2148564489 hasAuthorship W2148564489A5023966597 @default.
• W2148564489 hasAuthorship W2148564489A5031265369 @default.
• W2148564489 hasAuthorship W2148564489A5034309539 @default.
• W2148564489 hasAuthorship W2148564489A5036306697 @default.
• W2148564489 hasAuthorship W2148564489A5049195131 @default.
• W2148564489 hasAuthorship W2148564489A5053372098 @default.
• W2148564489 hasAuthorship W2148564489A5059654966 @default.
• W2148564489 hasAuthorship W2148564489A5071471535 @default.
• W2148564489 hasAuthorship W2148564489A5080024907 @default.
• W2148564489 hasAuthorship W2148564489A5080447100 @default.
• W2148564489 hasConcept C126322002 @default.
• W2148564489 hasConcept C134018914 @default.
• W2148564489 hasConcept C2776825266 @default.
• W2148564489 hasConcept C2776919658 @default.
• W2148564489 hasConcept C2778096610 @default.
• W2148564489 hasConcept C2778163477 @default.
• W2148564489 hasConcept C2778772119 @default.
• W2148564489 hasConcept C2778913445 @default.
• W2148564489 hasConcept C2779091943 @default.
• W2148564489 hasConcept C2779134260 @default.
• W2148564489 hasConcept C2780972559 @default.
• W2148564489 hasConcept C555293320 @default.
• W2148564489 hasConcept C62746215 @default.
• W2148564489 hasConcept C71924100 @default.
• W2148564489 hasConceptScore W2148564489C126322002 @default.
• W2148564489 hasConceptScore W2148564489C134018914 @default.
• W2148564489 hasConceptScore W2148564489C2776825266 @default.
• W2148564489 hasConceptScore W2148564489C2776919658 @default.
• W2148564489 hasConceptScore W2148564489C2778096610 @default.
• W2148564489 hasConceptScore W2148564489C2778163477 @default.

• next