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- W2148636468 abstract "To elucidate the subacute toxic reactions to parenteral administration of Ni 2+ , male F-344 rats were given daily injections of NiCl 2 (62.5 or 125 μmol/kg, sc) for 3 to 6 weeks. Nickel accumulation was greater in lung than in the other major organs, based upon tissue analyses by electrothermal atomic absorption spectrometry. After 5 or 6 weeks of NiCl 2 treatment, severe pathological changes developed in the lungs, including a) prominent hydropic and degenerative changes of the endothelium of pulmonary arteries and veins; b) marked proliferation of alveolar lining cells, affecting Type II (granular) pneumocytes; c) thickening of alveolar walls, with proteinaceous alveolar exudate; d) hyperplasia of bronchial epithelium, with cellular atypia and mitoses; and e) focal bronchial pneumonia with intrabronchial exudates. These pulmonary responses to repeated daily injections of NiCl 2 were substantially different from the pathological lesions seen 24 to 72 hours after a single sc injection of NiCl 2 (500 or 750 μmol/kg), which included perivascular edema, karyorrhexis and pyknosis of mononuclear cells in focal perivascular infiltrates, and mild pulmonary congestion. This study shows that the lung is a primary site of toxicity in rats following parenteral administration of NiCl 2 ; vascular endothelial cells, Type II pneumocytes, bronchial epithelial cells, and mononuclear cells constitute the principal cellular targets for pulmonary toxicity of Ni 2+ ." @default.
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- W2148636468 date "1988-04-01" @default.
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- W2148636468 title "Pulmonary Histopathology of Rats Following Parenteral Injections of Nickel Chloride" @default.
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- W2148636468 doi "https://doi.org/10.1177/019262338801600306" @default.
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