FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2148636523> ?p ?o ?g. }

• W2148636523 endingPage "87" @default.
• W2148636523 startingPage "77" @default.
• W2148636523 abstract "Intradermal inoculation of rats at the tail base with Mycobacterium butyricum led to the gradual development of an arthritic swelling of the limbs which peaked at 3 weeks and subsided thereafter. Arthritic rats displayed a loss of body weight, hypophagia, and hypodipsia in addition to a disruption of the diurnal rhythms of ingestive behavior and of core temperature. The activity of adenohypophyseal beta-endorphin-(beta-EP) secreting corticotrophs, in contrast to prolactin-(PRL) secreting lactotrophs, was increased in arthritic rats. Indeed, hypertrophy of the adrenal glands was seen. Arthritic rats also showed an elevation in spinal cord levels of immunoreactive dynorphin (DYN), an endogenous ligand of the kappa-opioid receptor. The paws and tail of arthritic rats showed lower thresholds in response to noxious pressure (hyperalgesia), higher thresholds in response to noxious heat (hypoalgesia), and no change in their response to noxious electrical stimulation. Neither naloxone nor ICI-154, 129 (a preferential delta-receptor antagonist) modified the responses of the paw or tail to pressure. However, MR 2266 (an antagonist with higher activity at kappa-receptors) decreased thresholds to pressure in arthritic, but not control, rats; that is, it potentiated the hyperalgesia. This action was stereospecific. None of the antagonists modified the response to heat. MR 2266 did not affect the response to pressure in rats with acute inflammation produced by yeast. Thus, the potentiation of pressure hyperalgesia by MR 2266 in chronic arthritic rats is highly selective. Arthritic rats showed a reduced response to the analgesic effect of a kappa-agonist (U-50,488H), whereas the response to a mu-agonist (morphine) was enhanced. These effects were specific to nociception in that their influence upon endocrine secretion (PRL and beta-EP) was otherwise changed. The secretion of beta-EP and PRL was stimulated by both morphine and U-50,488H, and the influence of U-50,488H upon the release of beta-EP (from the adenohypophysis) was enhanced in arthritic rats. It is suggested that polyarthritis is a complex condition entailing many changes, both behavioral and endocrinological. Further, arthritic rats cannot simply be described as hyperalgesic: of critical importance is the nature of the nociceptive stimulus applied. The parallel alterations in spinal cord pools of DYN and kappa-receptors (see also Millan et al., 1986) and the changes in the influence on nociception of kappa-agonists and kappa-antagonists suggest an increased activity of spinal DYN. Thus, spinal kappa-receptors may play a role in the modulation of nociception under chronic pain.(ABSTRACT TRUNCATED AT 400 WORDS)" @default.
• W2148636523 created "2016-06-24" @default.
• W2148636523 creator A5012967009 @default.
• W2148636523 creator A5019734071 @default.
• W2148636523 creator A5025838601 @default.
• W2148636523 creator A5038633189 @default.
• W2148636523 creator A5063508837 @default.
• W2148636523 creator A5063595895 @default.
• W2148636523 creator A5088116743 @default.
• W2148636523 date "1987-01-01" @default.
• W2148636523 modified "2023-10-14" @default.
• W2148636523 title "A model of chronic pain in the rat: functional correlates of alterations in the activity of opioid systems" @default.
• W2148636523 cites W1532997269 @default.
• W2148636523 cites W1752238143 @default.
• W2148636523 cites W1868713629 @default.
• W2148636523 cites W1887482200 @default.
• W2148636523 cites W1918878012 @default.
• W2148636523 cites W1965208005 @default.
• W2148636523 cites W1967922947 @default.
• W2148636523 cites W1971786611 @default.
• W2148636523 cites W1978918482 @default.
• W2148636523 cites W1979840776 @default.
• W2148636523 cites W1980762966 @default.
• W2148636523 cites W1986869543 @default.
• W2148636523 cites W1987236883 @default.
• W2148636523 cites W1992697324 @default.
• W2148636523 cites W2001670107 @default.
• W2148636523 cites W2005869462 @default.
• W2148636523 cites W2006032677 @default.
• W2148636523 cites W2009142791 @default.
• W2148636523 cites W2010584059 @default.
• W2148636523 cites W2015759461 @default.
• W2148636523 cites W2016907357 @default.
• W2148636523 cites W2017190337 @default.
• W2148636523 cites W2018126125 @default.
• W2148636523 cites W2018198178 @default.
• W2148636523 cites W2019763492 @default.
• W2148636523 cites W2019982440 @default.
• W2148636523 cites W2023555221 @default.
• W2148636523 cites W2027498069 @default.
• W2148636523 cites W2028368668 @default.
• W2148636523 cites W2031426580 @default.
• W2148636523 cites W2040831708 @default.
• W2148636523 cites W2041199817 @default.
• W2148636523 cites W2045290859 @default.
• W2148636523 cites W2061597478 @default.
• W2148636523 cites W2066631048 @default.
• W2148636523 cites W2072212851 @default.
• W2148636523 cites W2075322499 @default.
• W2148636523 cites W2077303695 @default.
• W2148636523 cites W2077339909 @default.
• W2148636523 cites W2077815340 @default.
• W2148636523 cites W2078741428 @default.
• W2148636523 cites W2084167599 @default.
• W2148636523 cites W2084881904 @default.
• W2148636523 cites W2087381547 @default.
• W2148636523 cites W2089171250 @default.
• W2148636523 cites W2093882465 @default.
• W2148636523 cites W2095165214 @default.
• W2148636523 cites W2138512124 @default.
• W2148636523 cites W2162679558 @default.
• W2148636523 cites W2283910779 @default.
• W2148636523 cites W2330497460 @default.
• W2148636523 cites W2398211970 @default.
• W2148636523 cites W2416302782 @default.
• W2148636523 doi "https://doi.org/10.1523/jneurosci.07-01-00077.1987" @default.
• W2148636523 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6568860" @default.
• W2148636523 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3027278" @default.
• W2148636523 hasPublicationYear "1987" @default.
• W2148636523 type Work @default.
• W2148636523 sameAs 2148636523 @default.
• W2148636523 citedByCount "108" @default.
• W2148636523 countsByYear W21486365232013 @default.
• W2148636523 countsByYear W21486365232014 @default.
• W2148636523 countsByYear W21486365232015 @default.
• W2148636523 countsByYear W21486365232016 @default.
• W2148636523 countsByYear W21486365232019 @default.
• W2148636523 countsByYear W21486365232020 @default.
• W2148636523 countsByYear W21486365232021 @default.
• W2148636523 countsByYear W21486365232022 @default.
• W2148636523 countsByYear W21486365232023 @default.
• W2148636523 crossrefType "journal-article" @default.
• W2148636523 hasAuthorship W2148636523A5012967009 @default.
• W2148636523 hasAuthorship W2148636523A5019734071 @default.
• W2148636523 hasAuthorship W2148636523A5025838601 @default.
• W2148636523 hasAuthorship W2148636523A5038633189 @default.
• W2148636523 hasAuthorship W2148636523A5063508837 @default.
• W2148636523 hasAuthorship W2148636523A5063595895 @default.
• W2148636523 hasAuthorship W2148636523A5088116743 @default.
• W2148636523 hasBestOaLocation W21486365231 @default.
• W2148636523 hasConcept C126322002 @default.
• W2148636523 hasConcept C134018914 @default.
• W2148636523 hasConcept C15490471 @default.
• W2148636523 hasConcept C170493617 @default.
• W2148636523 hasConcept C185592680 @default.
• W2148636523 hasConcept C2778938600 @default.
• W2148636523 hasConcept C2779245659 @default.
• W2148636523 hasConcept C2781199918 @default.

• next