Matches in SemOpenAlex for { <https://semopenalex.org/work/W2148657372> ?p ?o ?g. }
- W2148657372 endingPage "740" @default.
- W2148657372 startingPage "723" @default.
- W2148657372 abstract "Following the introduction of targeted therapy with tyrosine kinase inhibitors (TKI) at the beginning of the past decade, the outcome of patients with Philadelphia-chromosome positive acute lymphoblastic leukemia (Ph+ ALL) has dramatically improved. Presently, the use of refined programs with first/second generation TKI's and chemotherapy together with allogeneic stem cell transplantation allow up to 50% of all patients to be cured. Further progress is expected with the new TKI ponatinib, overcoming resistance caused by T315I point mutation, other targeted therapies, autologous transplantation in molecularly negative patients, therapeutic monoclonal antibodies like inotuzumab ozogamicin and blinatumomab, and chimeric antigen receptor-modified T cells. Ph+ ALL could become curable in the near future even without allogeneic stem cell transplantation, minimizing the risk of therapy-related death and improving greatly the quality of patients' life." @default.
- W2148657372 created "2016-06-24" @default.
- W2148657372 creator A5001591385 @default.
- W2148657372 creator A5004450449 @default.
- W2148657372 creator A5008839925 @default.
- W2148657372 creator A5017931505 @default.
- W2148657372 creator A5020919090 @default.
- W2148657372 creator A5036411593 @default.
- W2148657372 creator A5048157024 @default.
- W2148657372 date "2014-03-10" @default.
- W2148657372 modified "2023-10-18" @default.
- W2148657372 title "Current and future management of Ph/BCR-ABL positive ALL" @default.
- W2148657372 cites W1249635699 @default.
- W2148657372 cites W1488000644 @default.
- W2148657372 cites W1513007231 @default.
- W2148657372 cites W1558827591 @default.
- W2148657372 cites W1644813534 @default.
- W2148657372 cites W175560591 @default.
- W2148657372 cites W1966456827 @default.
- W2148657372 cites W1970135399 @default.
- W2148657372 cites W1972723665 @default.
- W2148657372 cites W1984877560 @default.
- W2148657372 cites W1989658067 @default.
- W2148657372 cites W1993808217 @default.
- W2148657372 cites W1994309500 @default.
- W2148657372 cites W1996697756 @default.
- W2148657372 cites W2003041273 @default.
- W2148657372 cites W2003581043 @default.
- W2148657372 cites W2004227940 @default.
- W2148657372 cites W2005282952 @default.
- W2148657372 cites W2007227525 @default.
- W2148657372 cites W2009008332 @default.
- W2148657372 cites W2011123917 @default.
- W2148657372 cites W2013779251 @default.
- W2148657372 cites W2014467271 @default.
- W2148657372 cites W2019591833 @default.
- W2148657372 cites W2020081659 @default.
- W2148657372 cites W2023595115 @default.
- W2148657372 cites W2026177698 @default.
- W2148657372 cites W2028104399 @default.
- W2148657372 cites W2033779669 @default.
- W2148657372 cites W2033862877 @default.
- W2148657372 cites W2036724262 @default.
- W2148657372 cites W2037148599 @default.
- W2148657372 cites W2038285590 @default.
- W2148657372 cites W2038414910 @default.
- W2148657372 cites W2038650283 @default.
- W2148657372 cites W2039201527 @default.
- W2148657372 cites W2040329520 @default.
- W2148657372 cites W2041353685 @default.
- W2148657372 cites W2051262530 @default.
- W2148657372 cites W2054295232 @default.
- W2148657372 cites W2054727430 @default.
- W2148657372 cites W2063530002 @default.
- W2148657372 cites W2064831267 @default.
- W2148657372 cites W2065851457 @default.
- W2148657372 cites W2068302119 @default.
- W2148657372 cites W2069040294 @default.
- W2148657372 cites W2070012795 @default.
- W2148657372 cites W2070382898 @default.
- W2148657372 cites W2070464547 @default.
- W2148657372 cites W2075876441 @default.
- W2148657372 cites W2076720738 @default.
- W2148657372 cites W2079788597 @default.
- W2148657372 cites W2080485907 @default.
- W2148657372 cites W2082189475 @default.
- W2148657372 cites W2087090648 @default.
- W2148657372 cites W2087671302 @default.
- W2148657372 cites W2089360398 @default.
- W2148657372 cites W2090982287 @default.
- W2148657372 cites W2095563873 @default.
- W2148657372 cites W2099616647 @default.
- W2148657372 cites W2099663271 @default.
- W2148657372 cites W2102929198 @default.
- W2148657372 cites W2104073210 @default.
- W2148657372 cites W2104694028 @default.
- W2148657372 cites W2105098746 @default.
- W2148657372 cites W2108322312 @default.
- W2148657372 cites W2109043126 @default.
- W2148657372 cites W2114358266 @default.
- W2148657372 cites W2118807674 @default.
- W2148657372 cites W2123940645 @default.
- W2148657372 cites W2124174337 @default.
- W2148657372 cites W2127226843 @default.
- W2148657372 cites W2130122821 @default.
- W2148657372 cites W2130160254 @default.
- W2148657372 cites W2130338247 @default.
- W2148657372 cites W2131067167 @default.
- W2148657372 cites W2134911461 @default.
- W2148657372 cites W2135224106 @default.
- W2148657372 cites W2135492799 @default.
- W2148657372 cites W2136161953 @default.
- W2148657372 cites W2137520438 @default.
- W2148657372 cites W2139098185 @default.
- W2148657372 cites W2139499066 @default.
- W2148657372 cites W2144447488 @default.
- W2148657372 cites W2150695629 @default.
- W2148657372 cites W2153824773 @default.