FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2148658259> ?p ?o ?g. }

• W2148658259 endingPage "1383" @default.
• W2148658259 startingPage "1372" @default.
• W2148658259 abstract "Red ginseng (RG) is the top-selling functional food in Korea, but is not recommended for use in hypertensive patients. This study was performed to determine the pharmacokinetic (PK) interaction between RG and amlodipine, an antihypertensive drug. RG (0, 0.5, 1, or 2 g/kg/d) was administered orally for 2 wk, and then amlodipine (10 mg/kg) was given orally, to Sprague-Dawley (SD) rats. Blood was collected at 0.08, 0.25, 1, 1.5, 2, 3, 6, 12, and 24 h after amlodipine administration. In intravenous (iv) study, RG (0, 1, or 2 g/kg/d) was administered orally to SD rats for 2 wk, followed by amlodipine (2 mg/kg) intravenously (iv). Plasma concentrations of amlodipine were analyzed using a high-pressure liquid chromatography–tandem mass system (LC-MS/MS). Oral administration of amlodipine produced an increase of time to maximum plasma concentration (tmax: 2.6, 4.1, 8.3, and 8.9 h at 0, 0.5, 1, and 2 g/kg/d, respectively), and a decrease of maximum plasma concentration (Cmax: 278.5, 212.4, 232.1, and 238.7 ng/ml at 0, 0.5, 1, and 2 g/kg/d, respectively.). However, the area under the concentration–time curve from time 0 to 24 h measurable concentration (AUC0-24 h was 3487.4, 2895.4, 3158.2, and 3495 ng/h/ml at 0, 0.5, 1, and 2 g/kg/d respectively) was not significantly changed among the different dose groups. Administration of amlodipine iv produced no significant changes in the apparent terminal half-life, volume of distribution, and AUC0-24 hr among the different dose groups. These results suggest that RG induced negligible influence on amlodipine pharmacokinetically in rats." @default.
• W2148658259 created "2016-06-24" @default.
• W2148658259 creator A5013181291 @default.
• W2148658259 creator A5022941061 @default.
• W2148658259 creator A5026612909 @default.
• W2148658259 creator A5028655016 @default.
• W2148658259 creator A5036092419 @default.
• W2148658259 creator A5040751996 @default.
• W2148658259 creator A5082448603 @default.
• W2148658259 creator A5085695905 @default.
• W2148658259 creator A5091034884 @default.
• W2148658259 date "2014-10-24" @default.
• W2148658259 modified "2023-10-02" @default.
• W2148658259 title "Negligible Pharmacokinetic Interaction of Red Ginseng and Antihypertensive Agent Amlodipine in Sprague-Dawley Rats" @default.
• W2148658259 cites W1924522868 @default.
• W2148658259 cites W1963655699 @default.
• W2148658259 cites W1968994172 @default.
• W2148658259 cites W1973201505 @default.
• W2148658259 cites W1980101667 @default.
• W2148658259 cites W1983298526 @default.
• W2148658259 cites W1984909355 @default.
• W2148658259 cites W1984988499 @default.
• W2148658259 cites W1987118114 @default.
• W2148658259 cites W1992746042 @default.
• W2148658259 cites W1995888369 @default.
• W2148658259 cites W2003556240 @default.
• W2148658259 cites W2009494586 @default.
• W2148658259 cites W2013848453 @default.
• W2148658259 cites W2016188249 @default.
• W2148658259 cites W2023187960 @default.
• W2148658259 cites W2026684480 @default.
• W2148658259 cites W2034615747 @default.
• W2148658259 cites W2041080192 @default.
• W2148658259 cites W2045280877 @default.
• W2148658259 cites W2048312777 @default.
• W2148658259 cites W2048848534 @default.
• W2148658259 cites W2049129255 @default.
• W2148658259 cites W2049985148 @default.
• W2148658259 cites W2062913054 @default.
• W2148658259 cites W2063075907 @default.
• W2148658259 cites W2069069910 @default.
• W2148658259 cites W2074279004 @default.
• W2148658259 cites W2075773961 @default.
• W2148658259 cites W2087713662 @default.
• W2148658259 cites W2112146600 @default.
• W2148658259 cites W2114738513 @default.
• W2148658259 cites W2122342236 @default.
• W2148658259 cites W2124571990 @default.
• W2148658259 cites W2124662083 @default.
• W2148658259 cites W2131892826 @default.
• W2148658259 cites W2139051233 @default.
• W2148658259 cites W2141659719 @default.
• W2148658259 cites W2144997134 @default.
• W2148658259 cites W2146768388 @default.
• W2148658259 cites W2148861687 @default.
• W2148658259 cites W2159602314 @default.
• W2148658259 cites W2608915729 @default.
• W2148658259 cites W4250535067 @default.
• W2148658259 doi "https://doi.org/10.1080/15287394.2014.951594" @default.
• W2148658259 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25343287" @default.
• W2148658259 hasPublicationYear "2014" @default.
• W2148658259 type Work @default.
• W2148658259 sameAs 2148658259 @default.
• W2148658259 citedByCount "14" @default.
• W2148658259 countsByYear W21486582592015 @default.
• W2148658259 countsByYear W21486582592016 @default.
• W2148658259 countsByYear W21486582592018 @default.
• W2148658259 countsByYear W21486582592019 @default.
• W2148658259 countsByYear W21486582592020 @default.
• W2148658259 countsByYear W21486582592022 @default.
• W2148658259 countsByYear W21486582592023 @default.
• W2148658259 crossrefType "journal-article" @default.
• W2148658259 hasAuthorship W2148658259A5013181291 @default.
• W2148658259 hasAuthorship W2148658259A5022941061 @default.
• W2148658259 hasAuthorship W2148658259A5026612909 @default.
• W2148658259 hasAuthorship W2148658259A5028655016 @default.
• W2148658259 hasAuthorship W2148658259A5036092419 @default.
• W2148658259 hasAuthorship W2148658259A5040751996 @default.
• W2148658259 hasAuthorship W2148658259A5082448603 @default.
• W2148658259 hasAuthorship W2148658259A5085695905 @default.
• W2148658259 hasAuthorship W2148658259A5091034884 @default.
• W2148658259 hasConcept C112705442 @default.
• W2148658259 hasConcept C134018914 @default.
• W2148658259 hasConcept C142724271 @default.
• W2148658259 hasConcept C185592680 @default.
• W2148658259 hasConcept C204787440 @default.
• W2148658259 hasConcept C22979827 @default.
• W2148658259 hasConcept C2777056448 @default.
• W2148658259 hasConcept C2779232237 @default.
• W2148658259 hasConcept C2779646130 @default.
• W2148658259 hasConcept C2992379925 @default.
• W2148658259 hasConcept C71924100 @default.
• W2148658259 hasConcept C84393581 @default.
• W2148658259 hasConcept C97320921 @default.
• W2148658259 hasConcept C98274493 @default.
• W2148658259 hasConceptScore W2148658259C112705442 @default.
• W2148658259 hasConceptScore W2148658259C134018914 @default.
• W2148658259 hasConceptScore W2148658259C142724271 @default.

• next