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• W2148669099 startingPage "1453" @default.
• W2148669099 abstract "Eukaryotic elongation factor 1 (eEF-1) contains the guanine nucleotide exchange factor eEF-1B that loads the G protein eEF-1A with GTP after each cycle of elongation during protein synthesis. Two features of eEF-1B have not yet been elucidated: (i) the presence of the unique valyl-tRNA synthetase; (ii) the significance of target sites for the cell cycle protein kinase CDK1/cyclin B. The roles of these two features were addressed by elongation measurements in vitro using cell-free extracts. A poly(GUA) template RNA was generated to support both poly(valine) and poly(serine) synthesis and poly(phenylalanine) synthesis was driven by a poly(uridylic acid) template. Elongation rates were in the order phenylalanine > valine > serine. Addition of CDK1/cyclin B decreased the elongation rate for valine whereas the rate for serine and phenylalanine elongation was increased. This effect was correlated with phosphorylation of the eEF-1delta and eEF-1gamma subunits of eEF-1B. Our results demonstrate specific regulation of elongation by CDK1/cyclin B phosphorylation." @default.
• W2148669099 created "2016-06-24" @default.
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• W2148669099 date "2001-04-01" @default.
• W2148669099 modified "2023-10-12" @default.
• W2148669099 title "Evidence for regulation of protein synthesis at the elongation step by CDK1/cyclin B phosphorylation" @default.
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• W2148669099 doi "https://doi.org/10.1093/nar/29.7.1453" @default.
• W2148669099 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/31266" @default.
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