Matches in SemOpenAlex for { <https://semopenalex.org/work/W2148678602> ?p ?o ?g. }
- W2148678602 endingPage "1118" @default.
- W2148678602 startingPage "1113" @default.
- W2148678602 abstract "Epithelial ovarian cancer is a major cause of mortality among women with gynecological malignancies. Paclitaxel is commonly used for chemotherapy of ovarian cancer, yet its efficacy is limited by chemoresistance. Generally, drug resistance is associated with acquisition of the epithelial-mesenchymal transition (EMT) in cancer. The aim of the present study was to determine whether the EMT is involved in acquired resistance to paclitaxel in A2780 human ovarian cancer cells. Using the paclitaxel-resistant A2780/PTX cell line, we examined the cellular morphology, molecular changes, migration and proliferation consistent with the EMT. Furthermore, we found that inhibition of phosphatidylinositol 3-kinase (PI3K) activity reduced the proliferation and migration and restored their sensitivity to paclitaxel. Our study provides new insights into EMT-like phenotypic changes that are linked to paclitaxel resistance in A2780 cells. We believe that inhibition of the PI3K signaling pathway could provide a novel therapeutic approach to overcome chemoresistance and prevent metastasis during paclitaxel chemotherapy." @default.
- W2148678602 created "2016-06-24" @default.
- W2148678602 creator A5000882682 @default.
- W2148678602 creator A5008924675 @default.
- W2148678602 creator A5009547640 @default.
- W2148678602 creator A5019405060 @default.
- W2148678602 creator A5019685555 @default.
- W2148678602 creator A5027455786 @default.
- W2148678602 creator A5041131049 @default.
- W2148678602 creator A5051200107 @default.
- W2148678602 creator A5059430503 @default.
- W2148678602 creator A5064075650 @default.
- W2148678602 creator A5075263470 @default.
- W2148678602 creator A5086154174 @default.
- W2148678602 creator A5088528117 @default.
- W2148678602 creator A5088665887 @default.
- W2148678602 date "2013-06-26" @default.
- W2148678602 modified "2023-10-10" @default.
- W2148678602 title "Acquisition of paclitaxel resistance via PI3K-dependent epithelial-mesenchymal transition in A2780 human ovarian cancer cells" @default.
- W2148678602 cites W1480706413 @default.
- W2148678602 cites W1973890143 @default.
- W2148678602 cites W1975887129 @default.
- W2148678602 cites W1979067350 @default.
- W2148678602 cites W1991242976 @default.
- W2148678602 cites W1996902769 @default.
- W2148678602 cites W2001135324 @default.
- W2148678602 cites W2001293278 @default.
- W2148678602 cites W2005852730 @default.
- W2148678602 cites W2013448031 @default.
- W2148678602 cites W2020020742 @default.
- W2148678602 cites W2038843789 @default.
- W2148678602 cites W2046104645 @default.
- W2148678602 cites W2061876263 @default.
- W2148678602 cites W2065629669 @default.
- W2148678602 cites W2071788049 @default.
- W2148678602 cites W2076583198 @default.
- W2148678602 cites W2087861588 @default.
- W2148678602 cites W2089487742 @default.
- W2148678602 cites W2122690307 @default.
- W2148678602 cites W2140838553 @default.
- W2148678602 cites W2166355008 @default.
- W2148678602 cites W2170556339 @default.
- W2148678602 doi "https://doi.org/10.3892/or.2013.2567" @default.
- W2148678602 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23807572" @default.
- W2148678602 hasPublicationYear "2013" @default.
- W2148678602 type Work @default.
- W2148678602 sameAs 2148678602 @default.
- W2148678602 citedByCount "42" @default.
- W2148678602 countsByYear W21486786022013 @default.
- W2148678602 countsByYear W21486786022014 @default.
- W2148678602 countsByYear W21486786022015 @default.
- W2148678602 countsByYear W21486786022016 @default.
- W2148678602 countsByYear W21486786022017 @default.
- W2148678602 countsByYear W21486786022018 @default.
- W2148678602 countsByYear W21486786022019 @default.
- W2148678602 countsByYear W21486786022020 @default.
- W2148678602 countsByYear W21486786022021 @default.
- W2148678602 countsByYear W21486786022022 @default.
- W2148678602 crossrefType "journal-article" @default.
- W2148678602 hasAuthorship W2148678602A5000882682 @default.
- W2148678602 hasAuthorship W2148678602A5008924675 @default.
- W2148678602 hasAuthorship W2148678602A5009547640 @default.
- W2148678602 hasAuthorship W2148678602A5019405060 @default.
- W2148678602 hasAuthorship W2148678602A5019685555 @default.
- W2148678602 hasAuthorship W2148678602A5027455786 @default.
- W2148678602 hasAuthorship W2148678602A5041131049 @default.
- W2148678602 hasAuthorship W2148678602A5051200107 @default.
- W2148678602 hasAuthorship W2148678602A5059430503 @default.
- W2148678602 hasAuthorship W2148678602A5064075650 @default.
- W2148678602 hasAuthorship W2148678602A5075263470 @default.
- W2148678602 hasAuthorship W2148678602A5086154174 @default.
- W2148678602 hasAuthorship W2148678602A5088528117 @default.
- W2148678602 hasAuthorship W2148678602A5088665887 @default.
- W2148678602 hasBestOaLocation W21486786021 @default.
- W2148678602 hasConcept C114851261 @default.
- W2148678602 hasConcept C121608353 @default.
- W2148678602 hasConcept C126322002 @default.
- W2148678602 hasConcept C143998085 @default.
- W2148678602 hasConcept C2776694085 @default.
- W2148678602 hasConcept C2777292972 @default.
- W2148678602 hasConcept C2779013556 @default.
- W2148678602 hasConcept C2780427987 @default.
- W2148678602 hasConcept C2781018059 @default.
- W2148678602 hasConcept C29537977 @default.
- W2148678602 hasConcept C502942594 @default.
- W2148678602 hasConcept C54355233 @default.
- W2148678602 hasConcept C62112901 @default.
- W2148678602 hasConcept C62478195 @default.
- W2148678602 hasConcept C67082663 @default.
- W2148678602 hasConcept C71924100 @default.
- W2148678602 hasConcept C76419328 @default.
- W2148678602 hasConcept C86554907 @default.
- W2148678602 hasConcept C86803240 @default.
- W2148678602 hasConcept C89423630 @default.
- W2148678602 hasConcept C95444343 @default.
- W2148678602 hasConcept C96232424 @default.
- W2148678602 hasConceptScore W2148678602C114851261 @default.
- W2148678602 hasConceptScore W2148678602C121608353 @default.