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• W2148678875 abstract "One of the fundamental features of the visual system is the segregation of neural circuits that process increments and decrements of luminance into ON and OFF pathways. In mature retina, the dendrites of retinal ganglion cells (RGCs) in the inner plexiform layer (IPL) of retina are separated into ON or OFF sublaminaspecific stratification. At an early developmental stage, however, the dendrites of most RGCs are ramified throughout the IPL. The maturation of RGC ON/OFF dendritic stratification requires neural activities mediated by afferent inputs from bipolar and amacrine cells. The synchronized spontaneous burst activities in early postnatal developing retina regulate RGC dendritic filopodial movements and the maintenance or elimination of dendritic processes. After eye opening, visual experience further remodels and consolidates the retinal neural circuit into mature forms. Several neurotransmitter systems, including glutamatergic, acetylcholinergic, GAB Aergic, and glycinergic systems, might act together to modulate the RGC dendritic refinement. In addition, both the bipolar cells and cholinergic amacrine cells may provide laminar cues for the maturation of RGC dendritic stratification." @default.
• W2148678875 created "2016-06-24" @default.
• W2148678875 creator A5003219089 @default.
• W2148678875 creator A5026113741 @default.
• W2148678875 date "2004-08-01" @default.
• W2148678875 modified "2023-10-16" @default.
• W2148678875 title "Pathway-Specific Maturation, Visual Deprivation, and Development of Retinal Pathway" @default.
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• W2148678875 doi "https://doi.org/10.1177/1073858404265254" @default.
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