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• W2148688519 endingPage "E861" @default.
• W2148688519 startingPage "E854" @default.
• W2148688519 abstract "Maternal undernutrition during gestation is known to be detrimental to fetal development, leading to a propensity for metabolic disorders later in the adult lives of the offspring. Identifying possible mediators and physiological processes involved in modulating nutrient transport within the placenta is essential to prevent and/or develop treatments for the effects of aberrant nutrition, nutrient transfer, and detrimental changes to fetal development. A potential role for myostatin as a mediator of nutrient uptake and transport from the mother to the fetus was shown through the recent finding that myostatin acts within the human placenta to modulate glucose uptake and therefore homeostasis. The mRNA and protein expression of myostatin and its inhibitor, follistatin-like-3 (FSTL3), was studied in the placenta and skeletal muscle of a transgenerational Wistar rat model of gestational maternal undernutrition in which the F2 offspring postweaning consumed a high-fat (HF) diet. Alterations in placental characteristics and offspring phenotype, specifically glucose homeostasis, were evident in the transgenerationally undernourished (UNAD) group. Myostatin and FSTL3 protein expression were also higher ( P < 0.05) in the placentae of the UNAD compared with the control group. At maturity, UNAD HF-fed animals had higher ( P < 0.05) skeletal muscle expression of FSTL3 than control animals. In summary, maternal undernutrition during gestation results in the aberrant regulation of myostatin and FSTL3 in the placenta and skeletal muscle of subsequent generations. Myostatin, through the disruption of maternal nutrient supply to the fetus, may thus be a potential mediator of offspring phenotype." @default.
• W2148688519 created "2016-06-24" @default.
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• W2148688519 date "2010-04-01" @default.
• W2148688519 modified "2023-10-15" @default.
• W2148688519 title "Placental expression of myostatin and follistatin-like-3 protein in a model of developmental programming" @default.
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• W2148688519 doi "https://doi.org/10.1152/ajpendo.00673.2009" @default.
• W2148688519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20103742" @default.
• W2148688519 hasPublicationYear "2010" @default.
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