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• W2148705835 abstract "Epigenetics represent heritable changes in gene expression that are not due to any alteration in the DNA sequence. One of the best-known epigenetic markers is histone acetylation, which has been shown to be deregulated in neoplastic diseases, including B-cell malignancies, such as Waldenström's Macroglobulinemia (WM), a low-grade B-cell lymphoma characterized by the presence of lymphoplasmacytic cells in the bone marrow and a serum monoclonal immunoglobulin M in the circulation. It has been recently demonstrated that microRNAs may be responsible for modulating histone acetylation in WM cells, thus providing the preclinical evidences for using microRNA-based therapeutic strategies in this disease." @default.
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• W2148705835 date "2011-02-01" @default.
• W2148705835 modified "2023-09-25" @default.
• W2148705835 title "Key Role of MicroRNAs in Waldenström's Macroglobulinemia Pathogenesis" @default.
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• W2148705835 doi "https://doi.org/10.3816/clml.2011.n.022" @default.
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