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- W2148774147 abstract "Proliferating cell nuclear antigen (PCNA) has been implicated in eukaryotic postreplicative mismatch correction, but the nature of its interaction with the repair machinery remained enigmatic. We now show that PCNA binds to the human mismatch binding factors hMutSα and hMutSβ via their hMSH6 and hMSH3 subunits, respectively. The N-terminal domains of both proteins contain the highly conserved PCNA-binding motif Qxx[LI]xx[FF]. A variant of hMutSα, lacking this motif because of deletion of 77 N-terminal residues of the hMSH6 subunit, no longer was able to interact with PCNA in vitro and failed to restore mismatch repair in hMSH6-deficient cells. Colocalization of PCNA and hMSH6 or hMSH3 to replication foci implies an intimate link between replication and mismatch correction. We postulate that PCNA plays a role in repair initiation by guiding the mismatch repair proteins to free termini in the newly replicated DNA strands." @default.
- W2148774147 created "2016-06-24" @default.
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- W2148774147 date "2001-03-15" @default.
- W2148774147 modified "2023-10-18" @default.
- W2148774147 title "hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci" @default.
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- W2148774147 cites W1569389754 @default.
- W2148774147 cites W1582040861 @default.
- W2148774147 cites W1589366730 @default.
- W2148774147 cites W1593576309 @default.
- W2148774147 cites W1979429824 @default.
- W2148774147 cites W1980462742 @default.
- W2148774147 cites W1983811214 @default.
- W2148774147 cites W1985882391 @default.
- W2148774147 cites W1986550053 @default.
- W2148774147 cites W1988134858 @default.
- W2148774147 cites W1990424405 @default.
- W2148774147 cites W1993073412 @default.
- W2148774147 cites W1994232734 @default.
- W2148774147 cites W1995719245 @default.
- W2148774147 cites W1998617902 @default.
- W2148774147 cites W1999375826 @default.
- W2148774147 cites W2006760092 @default.
- W2148774147 cites W2008246839 @default.
- W2148774147 cites W2012867725 @default.
- W2148774147 cites W2014571977 @default.
- W2148774147 cites W2014734846 @default.
- W2148774147 cites W2017161034 @default.
- W2148774147 cites W2020633581 @default.
- W2148774147 cites W2021885915 @default.
- W2148774147 cites W2024908018 @default.
- W2148774147 cites W2026388436 @default.
- W2148774147 cites W2039152230 @default.
- W2148774147 cites W2040135708 @default.
- W2148774147 cites W2047433802 @default.
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- W2148774147 cites W2067215249 @default.
- W2148774147 cites W2075182125 @default.
- W2148774147 cites W2075637141 @default.
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- W2148774147 doi "https://doi.org/10.1101/gad.191201" @default.
- W2148774147 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/312660" @default.
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