FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2148774610> ?p ?o ?g. }

• W2148774610 endingPage "2022" @default.
• W2148774610 startingPage "2015" @default.
• W2148774610 abstract "Abstract Monoclonal anti-CD3 Abs have been used clinically for two decades to reverse steroid-resistant acute graft rejection. In autoimmune diabetes, short course treatment with FcR-nonbinding (FNB) anti-CD3 mAb in mice with recent onset of diabetes induces long-term disease remission. Induction of tolerogenic regulatory T cells (Tregs) has been implicated to be one of the mechanisms of action by FNB anti-CD3 mAb in these settings. In this study, we examined the effect of FNB anti-CD3 mAb treatment on the homeostasis of naive, effector, and regulatory T cells in vivo. Anti-CD3 treatment induced a transient systemic rise in the percentage but not absolute number of CD4+Foxp3+ Tregs due to selective depletion of CD4+Foxp3− conventional T cells. T cell depletion induced by FNB anti-CD3 mAb was independent of the proapoptotic proteins Fas, caspase-3, and Bim and was not inhibited by overexpression of the anti-apoptotic protein, Bcl-2. Tregs were not preferentially expanded and we found no evidence of conversion of conventional T cells into Tregs, suggesting that the pre-existing Tregs are resistant to anti-CD3–induced cell death. Interestingly, expression of the transcription factor Helios, which is expressed by thymus-derived natural Tregs, was increased in Tregs after FNB anti-CD3 mAb treatment, suggesting that the anti-CD3 treatment can alter, and potentially stabilize, Treg function. Taken together, the results suggest that FNB anti-CD3 therapy promotes tolerance by restoring the balance between pathogenic and regulatory T cells." @default.
• W2148774610 created "2016-06-24" @default.
• W2148774610 creator A5028331971 @default.
• W2148774610 creator A5058743965 @default.
• W2148774610 creator A5080800763 @default.
• W2148774610 date "2011-08-15" @default.
• W2148774610 modified "2023-10-11" @default.
• W2148774610 title "Anti-CD3 Therapy Promotes Tolerance by Selectively Depleting Pathogenic Cells while Preserving Regulatory T Cells" @default.
• W2148774610 cites W1483697311 @default.
• W2148774610 cites W1547076546 @default.
• W2148774610 cites W1568831589 @default.
• W2148774610 cites W1588875541 @default.
• W2148774610 cites W1950937988 @default.
• W2148774610 cites W1963770029 @default.
• W2148774610 cites W1976883744 @default.
• W2148774610 cites W1992067519 @default.
• W2148774610 cites W1995043914 @default.
• W2148774610 cites W1997673739 @default.
• W2148774610 cites W2001212142 @default.
• W2148774610 cites W2032218738 @default.
• W2148774610 cites W2041266914 @default.
• W2148774610 cites W2042825771 @default.
• W2148774610 cites W2043150569 @default.
• W2148774610 cites W2052919634 @default.
• W2148774610 cites W2056088597 @default.
• W2148774610 cites W2062142808 @default.
• W2148774610 cites W2064376469 @default.
• W2148774610 cites W2066961467 @default.
• W2148774610 cites W2068521142 @default.
• W2148774610 cites W2086095524 @default.
• W2148774610 cites W2108813293 @default.
• W2148774610 cites W2111329034 @default.
• W2148774610 cites W2111650534 @default.
• W2148774610 cites W2112239380 @default.
• W2148774610 cites W2117002902 @default.
• W2148774610 cites W2132837430 @default.
• W2148774610 cites W2146536244 @default.
• W2148774610 cites W2150901150 @default.
• W2148774610 cites W2152642587 @default.
• W2148774610 cites W2153085696 @default.
• W2148774610 cites W2156694159 @default.
• W2148774610 cites W2162675860 @default.
• W2148774610 cites W2164196729 @default.
• W2148774610 cites W2405839966 @default.
• W2148774610 doi "https://doi.org/10.4049/jimmunol.1100713" @default.
• W2148774610 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3150219" @default.
• W2148774610 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21742976" @default.
• W2148774610 hasPublicationYear "2011" @default.
• W2148774610 type Work @default.
• W2148774610 sameAs 2148774610 @default.
• W2148774610 citedByCount "139" @default.
• W2148774610 countsByYear W21487746102012 @default.
• W2148774610 countsByYear W21487746102013 @default.
• W2148774610 countsByYear W21487746102014 @default.
• W2148774610 countsByYear W21487746102015 @default.
• W2148774610 countsByYear W21487746102016 @default.
• W2148774610 countsByYear W21487746102017 @default.
• W2148774610 countsByYear W21487746102018 @default.
• W2148774610 countsByYear W21487746102019 @default.
• W2148774610 countsByYear W21487746102020 @default.
• W2148774610 countsByYear W21487746102021 @default.
• W2148774610 countsByYear W21487746102022 @default.
• W2148774610 countsByYear W21487746102023 @default.
• W2148774610 crossrefType "journal-article" @default.
• W2148774610 hasAuthorship W2148774610A5028331971 @default.
• W2148774610 hasAuthorship W2148774610A5058743965 @default.
• W2148774610 hasAuthorship W2148774610A5080800763 @default.
• W2148774610 hasBestOaLocation W21487746101 @default.
• W2148774610 hasConcept C114684123 @default.
• W2148774610 hasConcept C159654299 @default.
• W2148774610 hasConcept C167672396 @default.
• W2148774610 hasConcept C203014093 @default.
• W2148774610 hasConcept C2776090121 @default.
• W2148774610 hasConcept C2778296632 @default.
• W2148774610 hasConcept C2779727006 @default.
• W2148774610 hasConcept C502942594 @default.
• W2148774610 hasConcept C542903549 @default.
• W2148774610 hasConcept C79484868 @default.
• W2148774610 hasConcept C86803240 @default.
• W2148774610 hasConcept C8891405 @default.
• W2148774610 hasConcept C95444343 @default.
• W2148774610 hasConceptScore W2148774610C114684123 @default.
• W2148774610 hasConceptScore W2148774610C159654299 @default.
• W2148774610 hasConceptScore W2148774610C167672396 @default.
• W2148774610 hasConceptScore W2148774610C203014093 @default.
• W2148774610 hasConceptScore W2148774610C2776090121 @default.
• W2148774610 hasConceptScore W2148774610C2778296632 @default.
• W2148774610 hasConceptScore W2148774610C2779727006 @default.
• W2148774610 hasConceptScore W2148774610C502942594 @default.
• W2148774610 hasConceptScore W2148774610C542903549 @default.
• W2148774610 hasConceptScore W2148774610C79484868 @default.
• W2148774610 hasConceptScore W2148774610C86803240 @default.
• W2148774610 hasConceptScore W2148774610C8891405 @default.
• W2148774610 hasConceptScore W2148774610C95444343 @default.
• W2148774610 hasIssue "4" @default.
• W2148774610 hasLocation W21487746101 @default.
• W2148774610 hasLocation W21487746102 @default.
• W2148774610 hasLocation W21487746103 @default.

• next