FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2148804537> ?p ?o ?g. }

• W2148804537 endingPage "553" @default.
• W2148804537 startingPage "545" @default.
• W2148804537 abstract "Summary The oxidation of methionine residues in proteins to methionine sulfoxides occurs frequently and protein repair by reduction of the methionine sulfoxides is mediated by an enzyme, peptide methionine sulfoxide reductase (PMSR, EC 1.8.4.6), universally present in the genomes of all so far sequenced organisms. Recently, five PMSR‐like genes were identified in Arabidopsis thaliana , including one plastidic isoform, chloroplast localised plastidial peptide methionine sulfoxide reductase (pPMSR) that was chloroplast‐localized and highly expressed in actively photosynthesizing tissue ( Sadanandom A et al ., 2000 ). However, no endogenous substrate to the pPMSR was identified. Here we report that a set of highly conserved methionine residues in Hsp21, a chloroplast‐localized small heat shock protein, can become sulfoxidized and thereafter reduced back to methionines by this pPMSR. The pPMSR activity was evaluated using recombinantly expressed pPMSR and Hsp21 from Arabidopsis thaliana and a direct detection of methionine sulfoxides in Hsp21 by mass spectrometry. The pPMSR‐catalyzed reduction of Hsp21 methionine sulfoxides occurred on a minute time‐scale, was ultimately DTT‐dependent and led to recovery of Hsp21 conformation and chaperone‐like activity, both of which are lost upon methionine sulfoxidation ( Härndahl et al ., 2001 ). These data indicate that one important function of pPMSR may be to prevent inactivation of Hsp21 by methionine sulfoxidation, since small heat shock proteins are crucial for cellular resistance to oxidative stress." @default.
• W2148804537 created "2016-06-24" @default.
• W2148804537 creator A5002078145 @default.
• W2148804537 creator A5003897538 @default.
• W2148804537 creator A5025282611 @default.
• W2148804537 creator A5031039093 @default.
• W2148804537 creator A5033151272 @default.
• W2148804537 creator A5036556106 @default.
• W2148804537 creator A5054956306 @default.
• W2148804537 creator A5079708107 @default.
• W2148804537 creator A5080044915 @default.
• W2148804537 date "2002-03-01" @default.
• W2148804537 modified "2023-10-15" @default.
• W2148804537 title "A peptide methionine sulfoxide reductase highly expressed in photosynthetic tissue in <i>Arabidopsis thaliana</i> can protect the chaperone‐like activity of a chloroplast‐localized small heat shock protein" @default.
• W2148804537 cites W1537274817 @default.
• W2148804537 cites W1965507089 @default.
• W2148804537 cites W1968072781 @default.
• W2148804537 cites W1968392253 @default.
• W2148804537 cites W1968411230 @default.
• W2148804537 cites W1977871129 @default.
• W2148804537 cites W1983570792 @default.
• W2148804537 cites W1991287144 @default.
• W2148804537 cites W1997678546 @default.
• W2148804537 cites W1998763047 @default.
• W2148804537 cites W2006903305 @default.
• W2148804537 cites W2009792344 @default.
• W2148804537 cites W2012206465 @default.
• W2148804537 cites W2014967055 @default.
• W2148804537 cites W2017240909 @default.
• W2148804537 cites W2022183036 @default.
• W2148804537 cites W2027562567 @default.
• W2148804537 cites W2037116841 @default.
• W2148804537 cites W2044031095 @default.
• W2148804537 cites W2046761749 @default.
• W2148804537 cites W2053096433 @default.
• W2148804537 cites W2060644195 @default.
• W2148804537 cites W2064526531 @default.
• W2148804537 cites W2072828921 @default.
• W2148804537 cites W2080682710 @default.
• W2148804537 cites W2084948611 @default.
• W2148804537 cites W2085180994 @default.
• W2148804537 cites W2086675715 @default.
• W2148804537 cites W2088938488 @default.
• W2148804537 cites W2089457861 @default.
• W2148804537 cites W2091058474 @default.
• W2148804537 cites W2107508146 @default.
• W2148804537 cites W2157853809 @default.
• W2148804537 cites W4236937091 @default.
• W2148804537 doi "https://doi.org/10.1046/j.1365-313x.2002.029005545.x" @default.
• W2148804537 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11874568" @default.
• W2148804537 hasPublicationYear "2002" @default.
• W2148804537 type Work @default.
• W2148804537 sameAs 2148804537 @default.
• W2148804537 citedByCount "100" @default.
• W2148804537 countsByYear W21488045372012 @default.
• W2148804537 countsByYear W21488045372013 @default.
• W2148804537 countsByYear W21488045372014 @default.
• W2148804537 countsByYear W21488045372015 @default.
• W2148804537 countsByYear W21488045372016 @default.
• W2148804537 countsByYear W21488045372017 @default.
• W2148804537 countsByYear W21488045372018 @default.
• W2148804537 countsByYear W21488045372019 @default.
• W2148804537 countsByYear W21488045372020 @default.
• W2148804537 countsByYear W21488045372021 @default.
• W2148804537 countsByYear W21488045372022 @default.
• W2148804537 crossrefType "journal-article" @default.
• W2148804537 hasAuthorship W2148804537A5002078145 @default.
• W2148804537 hasAuthorship W2148804537A5003897538 @default.
• W2148804537 hasAuthorship W2148804537A5025282611 @default.
• W2148804537 hasAuthorship W2148804537A5031039093 @default.
• W2148804537 hasAuthorship W2148804537A5033151272 @default.
• W2148804537 hasAuthorship W2148804537A5036556106 @default.
• W2148804537 hasAuthorship W2148804537A5054956306 @default.
• W2148804537 hasAuthorship W2148804537A5079708107 @default.
• W2148804537 hasAuthorship W2148804537A5080044915 @default.
• W2148804537 hasBestOaLocation W21488045371 @default.
• W2148804537 hasConcept C104317684 @default.
• W2148804537 hasConcept C142724271 @default.
• W2148804537 hasConcept C143065580 @default.
• W2148804537 hasConcept C2775962898 @default.
• W2148804537 hasConcept C2775988993 @default.
• W2148804537 hasConcept C2777568990 @default.
• W2148804537 hasConcept C2778813780 @default.
• W2148804537 hasConcept C2779458865 @default.
• W2148804537 hasConcept C2779491563 @default.
• W2148804537 hasConcept C2780912031 @default.
• W2148804537 hasConcept C515207424 @default.
• W2148804537 hasConcept C55493867 @default.
• W2148804537 hasConcept C69305403 @default.
• W2148804537 hasConcept C71924100 @default.
• W2148804537 hasConcept C86803240 @default.
• W2148804537 hasConceptScore W2148804537C104317684 @default.
• W2148804537 hasConceptScore W2148804537C142724271 @default.
• W2148804537 hasConceptScore W2148804537C143065580 @default.
• W2148804537 hasConceptScore W2148804537C2775962898 @default.
• W2148804537 hasConceptScore W2148804537C2775988993 @default.
• W2148804537 hasConceptScore W2148804537C2777568990 @default.
• W2148804537 hasConceptScore W2148804537C2778813780 @default.

• next