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- W2148807789 abstract "Maintenance of chromosomal stability relies on coordination between various processes that are critical for proper chromosome segregation in mitosis. Here we show that monopolar spindle 1 (Mps1) kinase, which is essential for the mitotic checkpoint, also controls correction of improper chromosome attachments. We report that Borealin/DasraB, a member of the complex that regulates the Aurora B kinase, is directly phosphorylated by Mps1 on residues that are crucial for Aurora B activity and chromosome alignment. As a result, cells lacking Mps1 kinase activity fail to efficiently align chromosomes due to impaired Aurora B function at centromeres, leaving improper attachments uncorrected. Strikingly, Borealin/DasraB bearing phosphomimetic mutations restores Aurora B activity and alignment in Mps1-depleted cells. Mps1 thus coordinates attachment error correction and checkpoint signaling, two crucial responses to unproductive chromosome attachments." @default.
- W2148807789 created "2016-06-24" @default.
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- W2148807789 date "2008-01-01" @default.
- W2148807789 modified "2023-10-15" @default.
- W2148807789 title "Mps1 Phosphorylates Borealin to Control Aurora B Activity and Chromosome Alignment" @default.
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- W2148807789 doi "https://doi.org/10.1016/j.cell.2007.11.046" @default.
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