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• W2148839497 abstract "The nuclear factor-kappaB (NF-kappaB)/Rel family of transcription factors has been implicated in promoting hepatocyte survival during development and liver regeneration following partial hepatectomy. Inhibition of NF-kappaB/Rel activity by microinjection of the specific inhibitor IkappaB-alpha induces apoptosis in a nontransformed normal murine hepatocyte (NMH) cell line. Here, we demonstrate that apoptosis resulting from such inhibition requires down-regulation of the c-Myc proto-oncoprotein and occurs independently of p53 tumor suppressor function. NMH cells plated at low density displayed low sensitivity to IkappaB-alpha-induced apoptosis and high levels of c-Myc protein expression. Comicroinjection of IkappaB-alpha with the c-Myc antagonist Mad1-glutathione S-transferase fusion protein greatly enhanced cell death. In addition, transient cotransfection of low-density NMH and AML12 hepatocytes with vectors expressing IkappaB-alpha and antisense c-myc transcripts promoted cell death. Conversely, ectopic c-myc expression significantly decreased the extent of cell death in NMH cells plated at saturating density, which were characterized by very low levels of c-Myc and high susceptibility to NF-kappaB inhibition-induced cell death. Finally, IkappaB-alpha-induced apoptosis was unaffected in NMH cells expressing a dominant negative p53 protein. Thus, NF-kappaB cooperates with c-Myc in promoting murine hepatocyte survival in a manner independent of p53 tumor suppressor activity." @default.
• W2148839497 created "2016-06-24" @default.
• W2148839497 creator A5057576176 @default.
• W2148839497 creator A5079640868 @default.
• W2148839497 date "1999-05-01" @default.
• W2148839497 modified "2023-09-23" @default.
• W2148839497 title "Nuclear factor kappaB cooperates with c-Myc in promoting murine hepatocyte survival in a manner independent of p53 tumor suppressor function." @default.
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• W2148839497 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10359010" @default.
• W2148839497 hasPublicationYear "1999" @default.
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