Matches in SemOpenAlex for { <https://semopenalex.org/work/W2148842703> ?p ?o ?g. }
- W2148842703 endingPage "872" @default.
- W2148842703 startingPage "865" @default.
- W2148842703 abstract "Catamenial epilepsy is a common phenomenon in female epileptic patients that is, in part, influenced by the 17-β-estradiol level during the menstrual cycle, which modulates the strength of the epileptic seizures. However, the underlying mechanism(s) for catamenial epilepsy remains unknown. In the present study, the effect of 17‑β‑estradiol on modulating epileptiform activities was investigated in cultured hippocampal neurons by focusing on the transient outward potassium current. Using the patch clamp technique, 17‑β‑estradiol was demonstrated to have a dose‑dependent U‑shape effect on epileptiform bursting activities in cultured hippocampal neurons; only the low dose (~0.1 ng/ml) of 17‑β‑estradiol had a suppressive effect on the epileptiform activities. The blockade effect of the low dose 17‑β‑estradiol could be suppressed by phrixotoxin2 (PaTx2), a selective channel blocker for voltage‑gated potassium channel type 4.2 (Kv4.2), which mediates the transient outward potassium current. Furthermore, the 17‑β‑estradiol bell‑shape‑like dose‑dependently enhanced the transient outward potassium current, which was inhibited by the estrogen receptor antagonist ICI 182,780. In conclusion, these results indicate that reduced activation of the transient outward potassium current by a high (or none) 17‑β‑estradiol level may enhance the epileptiform bursting activities in neurons, which may be one of the triggering causes for catamenial epilepsy, and therefore, maintaining a certain low 17‑β‑estradiol level may aid in the control of catamenial epilepsy." @default.
- W2148842703 created "2016-06-24" @default.
- W2148842703 creator A5006822602 @default.
- W2148842703 creator A5009613920 @default.
- W2148842703 creator A5027079456 @default.
- W2148842703 creator A5068979363 @default.
- W2148842703 creator A5080207575 @default.
- W2148842703 creator A5090866980 @default.
- W2148842703 date "2015-07-16" @default.
- W2148842703 modified "2023-09-28" @default.
- W2148842703 title "Estrogen suppresses epileptiform activity by enhancing Kv4.2-mediated transient outward potassium currents in primary hippocampal neurons" @default.
- W2148842703 cites W1492219502 @default.
- W2148842703 cites W1549050411 @default.
- W2148842703 cites W1551264738 @default.
- W2148842703 cites W1558006351 @default.
- W2148842703 cites W1602629579 @default.
- W2148842703 cites W1806370607 @default.
- W2148842703 cites W1966060400 @default.
- W2148842703 cites W1974846950 @default.
- W2148842703 cites W1975424106 @default.
- W2148842703 cites W1976090195 @default.
- W2148842703 cites W1977892849 @default.
- W2148842703 cites W1979707445 @default.
- W2148842703 cites W1979787584 @default.
- W2148842703 cites W1982736626 @default.
- W2148842703 cites W1986244156 @default.
- W2148842703 cites W1988004129 @default.
- W2148842703 cites W1998484141 @default.
- W2148842703 cites W2009832736 @default.
- W2148842703 cites W2017535935 @default.
- W2148842703 cites W2021304032 @default.
- W2148842703 cites W2022792151 @default.
- W2148842703 cites W2022871622 @default.
- W2148842703 cites W2029281250 @default.
- W2148842703 cites W2051024082 @default.
- W2148842703 cites W2062148835 @default.
- W2148842703 cites W2063227404 @default.
- W2148842703 cites W2080044736 @default.
- W2148842703 cites W2081999375 @default.
- W2148842703 cites W2086141948 @default.
- W2148842703 cites W2087519172 @default.
- W2148842703 cites W2095480028 @default.
- W2148842703 cites W2108981599 @default.
- W2148842703 cites W2132593434 @default.
- W2148842703 cites W2139089074 @default.
- W2148842703 cites W2140161138 @default.
- W2148842703 cites W2141297330 @default.
- W2148842703 cites W2168895138 @default.
- W2148842703 cites W2404672629 @default.
- W2148842703 cites W4233635697 @default.
- W2148842703 cites W4293872195 @default.
- W2148842703 doi "https://doi.org/10.3892/ijmm.2015.2287" @default.
- W2148842703 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26179130" @default.
- W2148842703 hasPublicationYear "2015" @default.
- W2148842703 type Work @default.
- W2148842703 sameAs 2148842703 @default.
- W2148842703 citedByCount "11" @default.
- W2148842703 countsByYear W21488427032017 @default.
- W2148842703 countsByYear W21488427032018 @default.
- W2148842703 countsByYear W21488427032019 @default.
- W2148842703 countsByYear W21488427032021 @default.
- W2148842703 countsByYear W21488427032022 @default.
- W2148842703 countsByYear W21488427032023 @default.
- W2148842703 crossrefType "journal-article" @default.
- W2148842703 hasAuthorship W2148842703A5006822602 @default.
- W2148842703 hasAuthorship W2148842703A5009613920 @default.
- W2148842703 hasAuthorship W2148842703A5027079456 @default.
- W2148842703 hasAuthorship W2148842703A5068979363 @default.
- W2148842703 hasAuthorship W2148842703A5080207575 @default.
- W2148842703 hasAuthorship W2148842703A5090866980 @default.
- W2148842703 hasBestOaLocation W21488427031 @default.
- W2148842703 hasConcept C126322002 @default.
- W2148842703 hasConcept C134018914 @default.
- W2148842703 hasConcept C147944092 @default.
- W2148842703 hasConcept C148762608 @default.
- W2148842703 hasConcept C169760540 @default.
- W2148842703 hasConcept C185263204 @default.
- W2148842703 hasConcept C185592680 @default.
- W2148842703 hasConcept C195221683 @default.
- W2148842703 hasConcept C2777164284 @default.
- W2148842703 hasConcept C2778186239 @default.
- W2148842703 hasConcept C2778457506 @default.
- W2148842703 hasConcept C71924100 @default.
- W2148842703 hasConcept C83743174 @default.
- W2148842703 hasConcept C86803240 @default.
- W2148842703 hasConcept C98274493 @default.
- W2148842703 hasConceptScore W2148842703C126322002 @default.
- W2148842703 hasConceptScore W2148842703C134018914 @default.
- W2148842703 hasConceptScore W2148842703C147944092 @default.
- W2148842703 hasConceptScore W2148842703C148762608 @default.
- W2148842703 hasConceptScore W2148842703C169760540 @default.
- W2148842703 hasConceptScore W2148842703C185263204 @default.
- W2148842703 hasConceptScore W2148842703C185592680 @default.
- W2148842703 hasConceptScore W2148842703C195221683 @default.
- W2148842703 hasConceptScore W2148842703C2777164284 @default.
- W2148842703 hasConceptScore W2148842703C2778186239 @default.
- W2148842703 hasConceptScore W2148842703C2778457506 @default.
- W2148842703 hasConceptScore W2148842703C71924100 @default.