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- W2148845396 abstract "The hypothesis was tested that an ultimate carcinogen of 7-hydroxymethyl-12-methylbenz[a]anthracene (HMBA), a major metabolite of 7,12-dimethylbenz[a]anthracene (DMBA), is a benzylic carbonium ion generated from an exceptionally reactive aralkylating metabolite, such as an electrophilic sulfate ester. In conformity with this hypothesis, sarcomas were rapidly induced in rats following repeated subcutaneous injection of HMBA (67%) or its electrophilic sulfate ester, sodium 7-sulfooxymethyl-12-methylbenz[a]anthracene (SMBA) (100%). It would appear from the results summarized here that the search for a carcinogenic metabolite of DMBA has been successful. In addition, an aralkylating electrophilic mutagen and carcinogen has been prepared from HMBA, which is itself either an ultimate carcinogen or a direct precursor of an ultimate carcinogen, i.e., a benzylic carbonium ion." @default.
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- W2148845396 date "1997-02-01" @default.
- W2148845396 modified "2023-09-27" @default.
- W2148845396 title "7-Sulfooxymethyl-12-methylbenz[a]anthracene Is an Exceptionally Reactive Electrophilic Mutagen and Ultimate Carcinogen" @default.
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- W2148845396 doi "https://doi.org/10.1006/bbrc.1997.6049" @default.
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