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• W2148873289 endingPage "131" @default.
• W2148873289 startingPage "121" @default.
• W2148873289 abstract "Artificial inducers have been used to study signal-transduction pathways involved in metamorphosis of some marine invertebrates. However, the transduction mechanisms for echinoderms have been less explored. In the present study, participation of protein kinase C (PKC), G-protein-coupled receptors (GPCRs), and calcium has been investigated during metamorphosis of the sea urchin Stronglylocentrotus purpuratus. Competent larvae were induced with different drugs that activate (PKC and GP activators, Ca2+ ionophores, and inhibitors of Ca2+ ATPase) or inhibit (PKC, G-protein, and Ca2+ flux inhibitors) metamorphosis. Six of the compounds were effective: the PKC activators TPA and indolactam; the G-protein inhibitors suramin and guanosine; the calcium ionophore A23187, and the calcium ATPase inhibitor thapsigargin. TPA was effective at 0.001 μM; indolactam was effective at 0.001 μM. In the presence of KCl as inducer, the G-protein inhibitor suramin was effective at 10 μM and guanosine at 0.001 μM. In the presence of a bacterial film as inducer, suramin was effective at 50 μM, and guanosine inhibited metamorphosis at 1 μM. A23187 was effective at 5 and 10 μM and thapsigargin at 50 and 100 μM. Our results indicate that GPCRs, protein kinase C, and calcium participate in the metamorphosis of S. purpuratus. These elements of the transduction pathways triggered during metamorphosis may be part of a cascade of signal transduction routes that interact from induction to the end of the morphogenetic events that shape the postlarval form. In addition, according to the results obtained with G-protein inhibitors, the GPCRs may be shared between the artificial (KCl) and natural (biofilm) inducers." @default.
• W2148873289 created "2016-06-24" @default.
• W2148873289 creator A5029098131 @default.
• W2148873289 creator A5035958976 @default.
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• W2148873289 date "2006-04-01" @default.
• W2148873289 modified "2023-10-17" @default.
• W2148873289 title "Role of Protein Kinase C, G-Protein Coupled Receptors, and Calcium Flux During Metamorphosis of the Sea Urchin<i>Strongylocentrotus purpuratus</i>" @default.
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• W2148873289 doi "https://doi.org/10.2307/4134601" @default.
• W2148873289 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16641517" @default.
• W2148873289 hasPublicationYear "2006" @default.
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