FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2148885539> ?p ?o ?g. }

• W2148885539 endingPage "456" @default.
• W2148885539 startingPage "445" @default.
• W2148885539 abstract "We have previously reported that the dendritic cell (DC) functional index cytokine interleukin-12 was significantly decreased in colorectal carcinoma (CRC) tissues. In this study, the DC infiltration pattern and the density of mature DCs (mDCs; labeled by anti-CD83 and anti-CD208) and immature DCs (iDCs; labeled by anti-CD1alpha) were characterized using immunohistochemistry (IHC) in tissue samples from 23 patients with CRC, 33 patients with colorectal adenoma (CRA), and 19 healthy controls. In addition, the DC function inhibitor cyclooxygenase-2 (COX-2) and the downstream signal molecule prostaglandin E2 (PGE2) and related receptors EP2/EP4 were measured by quantitative real-time PCR and double immunofluorescence staining. The IHC analyses revealed changed densities of mDCs and iDCs in the tumor microenvironment; in CRA and CRC, the density of mDCs was decreased, but the density of iDCs was gradually increased. Furthermore, the distribution patterns of DCs were also altered. In CRA, mDCs were abundantly distributed in the subepithelial stroma of the adenomatous mass. In CRC, the distribution of mDCs in the tumor stroma was not homogeneous, and mDCs residing in the stroma at invading edges were more frequently found compared with in the intratumoral stroma (P<0.05). Increased iDCs were found in the intratumoral mass in CRC, and some infiltrated into the malignant epithelium. By quantitative real-time PCR, a gradually increased level of COX-2 mRNA was demonstrated in the local tissues along the adenoma-carcinoma sequence, and double immunofluorescence staining showed a colocalization of PGE2 receptors EP2/EP4 with mDCs in the stroma of CRC. In conclusion, our current findings revealed an altered DC infiltration pattern along the adenoma-carcinoma sequence; gradually increased COX-2 expression might contribute to the DC functional defect." @default.
• W2148885539 created "2016-06-24" @default.
• W2148885539 creator A5003540830 @default.
• W2148885539 creator A5020129091 @default.
• W2148885539 creator A5032365251 @default.
• W2148885539 creator A5032742125 @default.
• W2148885539 creator A5054445577 @default.
• W2148885539 creator A5062560095 @default.
• W2148885539 creator A5079286577 @default.
• W2148885539 date "2008-06-01" @default.
• W2148885539 modified "2023-10-15" @default.
• W2148885539 title "Dendritic cell infiltration pattern along the colorectal adenoma-carcinoma sequence" @default.
• W2148885539 cites W1534491890 @default.
• W2148885539 cites W1571520647 @default.
• W2148885539 cites W1769928764 @default.
• W2148885539 cites W1963939177 @default.
• W2148885539 cites W1964151408 @default.
• W2148885539 cites W1999621861 @default.
• W2148885539 cites W2002235017 @default.
• W2148885539 cites W2010047180 @default.
• W2148885539 cites W2012148175 @default.
• W2148885539 cites W2020536006 @default.
• W2148885539 cites W2024598709 @default.
• W2148885539 cites W2027451729 @default.
• W2148885539 cites W2032868971 @default.
• W2148885539 cites W2033623558 @default.
• W2148885539 cites W2033877575 @default.
• W2148885539 cites W2037309485 @default.
• W2148885539 cites W2039880112 @default.
• W2148885539 cites W2068971398 @default.
• W2148885539 cites W2079344363 @default.
• W2148885539 cites W2084708073 @default.
• W2148885539 cites W2086044294 @default.
• W2148885539 cites W2088479878 @default.
• W2148885539 cites W2103045841 @default.
• W2148885539 cites W2120930368 @default.
• W2148885539 cites W2125633424 @default.
• W2148885539 cites W2139133924 @default.
• W2148885539 cites W2143745748 @default.
• W2148885539 cites W2159454668 @default.
• W2148885539 cites W2160313094 @default.
• W2148885539 cites W2166146826 @default.
• W2148885539 cites W2168892798 @default.
• W2148885539 doi "https://doi.org/10.1111/j.1600-0463.2008.00879.x" @default.
• W2148885539 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18752487" @default.
• W2148885539 hasPublicationYear "2008" @default.
• W2148885539 type Work @default.
• W2148885539 sameAs 2148885539 @default.
• W2148885539 citedByCount "42" @default.
• W2148885539 countsByYear W21488855392012 @default.
• W2148885539 countsByYear W21488855392013 @default.
• W2148885539 countsByYear W21488855392014 @default.
• W2148885539 countsByYear W21488855392015 @default.
• W2148885539 countsByYear W21488855392016 @default.
• W2148885539 countsByYear W21488855392017 @default.
• W2148885539 countsByYear W21488855392018 @default.
• W2148885539 countsByYear W21488855392019 @default.
• W2148885539 countsByYear W21488855392020 @default.
• W2148885539 countsByYear W21488855392021 @default.
• W2148885539 countsByYear W21488855392022 @default.
• W2148885539 countsByYear W21488855392023 @default.
• W2148885539 crossrefType "journal-article" @default.
• W2148885539 hasAuthorship W2148885539A5003540830 @default.
• W2148885539 hasAuthorship W2148885539A5020129091 @default.
• W2148885539 hasAuthorship W2148885539A5032365251 @default.
• W2148885539 hasAuthorship W2148885539A5032742125 @default.
• W2148885539 hasAuthorship W2148885539A5054445577 @default.
• W2148885539 hasAuthorship W2148885539A5062560095 @default.
• W2148885539 hasAuthorship W2148885539A5079286577 @default.
• W2148885539 hasConcept C121608353 @default.
• W2148885539 hasConcept C142724271 @default.
• W2148885539 hasConcept C16930146 @default.
• W2148885539 hasConcept C204232928 @default.
• W2148885539 hasConcept C2776861080 @default.
• W2148885539 hasConcept C2777546739 @default.
• W2148885539 hasConcept C52124034 @default.
• W2148885539 hasConcept C526805850 @default.
• W2148885539 hasConcept C54355233 @default.
• W2148885539 hasConcept C71924100 @default.
• W2148885539 hasConcept C86803240 @default.
• W2148885539 hasConceptScore W2148885539C121608353 @default.
• W2148885539 hasConceptScore W2148885539C142724271 @default.
• W2148885539 hasConceptScore W2148885539C16930146 @default.
• W2148885539 hasConceptScore W2148885539C204232928 @default.
• W2148885539 hasConceptScore W2148885539C2776861080 @default.
• W2148885539 hasConceptScore W2148885539C2777546739 @default.
• W2148885539 hasConceptScore W2148885539C52124034 @default.
• W2148885539 hasConceptScore W2148885539C526805850 @default.
• W2148885539 hasConceptScore W2148885539C54355233 @default.
• W2148885539 hasConceptScore W2148885539C71924100 @default.
• W2148885539 hasConceptScore W2148885539C86803240 @default.
• W2148885539 hasIssue "6" @default.
• W2148885539 hasLocation W21488855391 @default.
• W2148885539 hasLocation W21488855392 @default.
• W2148885539 hasOpenAccess W2148885539 @default.
• W2148885539 hasPrimaryLocation W21488855391 @default.
• W2148885539 hasRelatedWork W169414703 @default.
• W2148885539 hasRelatedWork W173733416 @default.

• next